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81.
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We extend Beckmann's spatial model of social interactions to the case of a two‐dimensional spatial economy with a large class of utility functions, accessing costs, and space‐dependent amenities. We show that spatial equilibria derive from a potential functional. By proving the existence of a minimizer of the functional, we obtain that of spatial equilibrium. Under mild conditions on the primitives of the economy, the functional is shown to satisfy displacement convexity. Moreover, the strict displacement convexity of the functional ensures the uniqueness of equilibrium. Also, the spatial symmetry of equilibrium is derived from that of the primitives of the economy.  相似文献   
83.
Objectives: To evaluate the cost-effectiveness of a Treat-to-Target strategy with certolizumab pegol in patients with rheumatoid arthritis in the context of a pay-for-performance agreement in which medication costs are refunded in case of discontinuation during the first 3 months of treatment.

Methods: The Treat-to-Target strategy consisted of a systematic switch to second-line tumor necrosis factor (TNF)α inhibitor in case of an unmet ACR50 response at 3 months compared to current routine clinical practice. A reference cohort treated first-line with certolizumab pegol according to current practice without systematic switching was considered as the comparator. A decision-tree model was constructed to estimate clinical outcome (health assessment questionnaire-disability index or HAQ-DI score), time spent in ACR50 response (ACR 50), and direct costs of treatment over a 2-year period. HAQ scores were derived from American College of Rheumatology 50 (ACR50) responses. All TNFα inhibitors were assumed to have equivalent efficacy and tolerability. Costs were estimated at 2013 French retail prices (date of the pay-for-performance agreement).

Results: The mean duration of an ACR50 response was 1.23 years in the Treat-to-Target strategy certolizumab pegol cohort vs 0.98 years in the reference cohort, resulting in a mean gain in HAQ at 24 months of 0.117. The Treat-to-Target strategy with a mix of TNFα inhibitors as second-line therapy was more expensive than the reference strategy in absolute terms, but this difference was entirely offset by the pay-for-performance agreement. The Treat-to-Target strategy was, thus, cost-neutral over a 2-year period after the payback of CZP cost for patients not achieving the target at 3 months.

Conclusions: In the context of a pay-for-performance agreement, the management of patients with rheumatoid arthritis using a Treat-to-Target strategy with certolizumab pegol in first line is dominant compared to standard use of this drug in the French setting in 2013.  相似文献   

84.
Abstract

By examining the rhetorical use of an old piece of economic theory by some contemporary economists, this paper intends to report on “how today's economists conduct a public policy debate”. This paper is neither a scholarly history of the interwar debate nor a sophisticated critique of current economic policy. It is an attempt to link the policy and theoretical arguments of two similar debates separated by nearly 80 years. The second part of the paper demonstrates that the (un-)expected return of the Treasury View is a case study illustrating two very different modelling strategies.  相似文献   
85.
This article aims to present and explain the potential of the real options theory. This theory can help solve many corporate problems in the field of investment strategies. It incorporates a wide range of internal and external factors that are playing a potential role in strategy outcome. The real options tool has already been applied in many industries and many divisions of their business. The main advantage of this methodology is that management is forced to develop a more structured thinking pad due to the fact that real options is based on a clear and accurate procedure. © 2001 John Wiley & Sons, Inc.  相似文献   
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The inability of European institutions to reform the common agricultural policy is a landmark case of political failure. The CAP has led to several policy failures. It helps mainly the well-off farmers in a very wasteful way; it provides excessive incentives for non-competitive primary commodities, specialization and intensification, with adverse impacts on rural natural resources. Economic principles support long-term programmes aimed only at market failures: the respect of environmental norms and the provision of rural public goods in line with society's demands. While not interfering with market mechanisms, the instruments we propose acknowledge the diverse economic potential of European rural areas and the variety of goods and services provided by the rural space. Political feasibility and social concerns may require a transitory period of direct income support for current farmers. We argue, however, against any direct payments for new farmers in order to prevent future dependence on public support.
Large established farmers are those who stand to lose the most from our proposals. However, they and those who represent them have to face the inefficiencies of the current policy and society's demands. Farmers deserve rewards from public funds for the rural public goods they provide, but these rewards should be decoupled and targeted. A profound reform is required if we are to preserve a 'European model of the countryside'.  相似文献   
89.
The Uruguay Round Agreement on Agriculture (URAA) was designed to reduce trade barriers and temper domestic and export policies that affect trade flows in agricultural commodities. This paper employs a dynamic framework to estimate the effects of the URAA on trade flows, as measured by export volumes, of three meat commodities. The model controls for several important factors, including regional trade agreements, and finds that the URAA had mixed effects on meat exports. Several complicating factors and policy responses, including increasing use of non-negotiated trade barriers, smaller export subsidies and domestic support, and limited effectiveness of market access provisions, explain the mixed empirical results.  相似文献   
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