Healthcare burden and reimbursement of hospitalization during chemotherapy for adults with Ph-negative relapsed or refractory B-cell precursor acute lymphoblastic leukemia in France: a retrospective chart review

Objective: Philadelphia chromosome negative [Ph(?)] relapsed or refractory (R/R) B-precursor acute lymphoblastic leukemia (ALL) is an extremely rare condition requiring intensive treatment. This retrospective chart review aimed to quantify hospitalizations and reimbursement in this patient population in France.

Methods: Patients aged ≥18 years and with at least one hospitalization for Ph(?) R/R B-precursor ALL were included in the study. They were relapsed with first remission lasting <12 months, relapsed after first salvage therapy, relapsed any time after hematopoietic stem cell transplant (HSCT), or were refractory to initial or salvage therapy. Data were collected from the index date (first diagnosis of R/R ALL) until death or loss to follow-up. The chemotherapy period was defined as the first chemotherapy date after the index date to the earliest of death, loss to follow-up, last chemotherapy dose plus 30 days, or initiation of HSCT. The primary outcome was the percentage of time hospitalized during the chemotherapy period.

Results: Thirty-three patients were included, with a mean age of 49 years. The mean proportion of time spent in the hospital during the chemotherapy period was 46% (95% CI =34–57%). Patients had a mean of 2.2 (SD =1.5) inpatient hospitalizations and the mean length of stay per hospitalization was 16.8 (SD =14.8) days. During the chemotherapy period, the mean amount reimbursed per hospitalization was €31 067 (SD = €4850) and the total hospitalization reimbursement per patient was €68 344. From the index date to death, excluding HSCT, the total reimbursement per patient was €108 873.

Limitations: The sample size was small, although this was expected given the rarity of the patient population.

Conclusions: Adults with Ph(?) R/R B-precursor ALL had repeated and prolonged hospitalizations during salvage chemotherapy. Approximately half the follow-up period was spent in the hospital, and this time was associated with high economic burden in France.     

Flight‐to‐safety and the credit crunch: a new history of the banking crises in France during the Great Depression†

Despite France's importance in the interwar world economy, the scale of the French banking crises of 1930–1 and their consequences have never been fully assessed quantitatively. The lack of banking regulation severely limited the availability of balance sheet data. Using a new dataset of individual balance sheets from more than 300 banks, this article shows that the crises were much more severe than previously thought, although they did not affect the main commercial banks. By reconstructing financial flows, this study shows that the fall in bank credit was mostly driven by a flight‐to‐safety by deposits, from banks to savings institutions and the central bank. The decrease in bank deposits due to bank runs was offset by an increase in deposits with savings institutions, with the central bank, and in cash hoarding, whereas the decrease in bank credit was not offset by an increase in loans from non‐bank financial institutions. In line with the gold standard mentality, cash deposited with savings institutions and the central bank was used to decrease marketable public debt and increase gold reserves, rather than pursuing countercyclical policies. Despite massive capital inflows and rising aggregate money supply, France suffered from a severe, persistent credit crunch.     

HOW DO RATING AGENCIES’ DECISIONS IMPACT STOCK MARKETS? A META‐ANALYSIS

The purpose of this study is to examine how credit rating agencies’ decisions impact the stock market using a systematic and quantitative review of existing empirical studies. Specifically, we employ a meta‐regression analysis (MRA) to investigate the extent and nature of the effect of rating agencies’ decisions on the stock market. We survey 62 studies published between 1978 and 2015. Our first finding is that the cumulative average abnormal returns calculated from this empirical literature are affected by publication bias. After controlling for publication bias, the main findings of our meta‐analysis indicate that negative rating decisions cause statistically significant negative abnormal returns. This evidence suggests an informational effect. Our results also indicate that positive rating decisions do not have a significant effect. Finally, the MRA results reveal the importance of several factors related to primary study design, as well as to the nature of the data.     

No News Is Good News: The Relationship Between Media Attention and Strike Duration

Media attention has been overlooked as a potential determinant of strike duration. This study analyzed the impact of media attention on strike duration using a sample of the 90 largest U.S. strikes that occurred from 1980 to 1991. Results indicated that a strong positive relationship exists between prestrike media attention and strike duration, even while controlling for strike size, organizational fame, the occurrence of a federal intervention, the involvement of a famous union, history of conflict, and broad industry categories. A possible social psychological explanation—bargaining parties behave rigidly in response to increases in public attention—is discussed.     

Transatlantic innovation infrastructure networks: public-private, EU–US R&D partnerships

Collaborative, team-based research is now the most significant mode of activity in the global scientific community. Anecdotal and statistical evidence shows moreover that collaboration in scientific research is increasingly global in nature. That is, the groups of researchers who are involved in scientific progress often span one or more nations in origin, location and/or sponsorship. Another significant trend in recent cases of scientific collaboration is the increase in cross-sectoral cooperation, where researchers in a group are employed by government, private industry, and/or academic and other non-profit institutions.
In this paper, we review the scale, scope and intensity of cross-national, cross-sectoral research collaboration through the analysis of historical data on co-authorship of scientific publications. The first part of the paper reviews existing literature on the analysis of co-authorship data, and discusses the limitations of this form of analysis and typical strategies to mitigate those limitations. The second part of the paper describes a preliminary study of cross-national, cross-sectoral scientific collaborations covering the years 1988 through 1997, where we examined the scale (volume of co-authored papers), intensity (co-authored papers versus other kinds of co-authorship), and scope (patterns in co-authorship) for cross-national, cross-sectoral collaborations. The conclusion of the paper discusses significant trends and patterns derived from this study, and their implications for further research into these types of collaborations.     

Identifying productivity when it is a factor of production

Economists typically model a plant's productivity as an exogenous characteristic, but the people who run and work at manufacturing plants make choices, at a cost, that affect plant productivity. I develop a method to partially identify the productivity distribution when such choices determine productivity. The method uses a monotone comparative static result I prove in a general economic model. It does not require instruments or timing assumptions. I use the method to study the effect of implementing market-based pricing on productivity in the electricity generation industry.     

Information Systems Project Abandonment: A Case of Political Influence by the Stakeholders

This paper serves as a stimulus to investigators to examine the role organizational politics plays in decisions leading to the abandonment of information systems (IS) projects. While prior research has identified the development of IS projects as a highly political process, where stakeholders may be more concerned about furthering their self-interests than about contributing to the overall success of the project, there has been little research on identifying the political factors contributing to IS project abandonment. Our case demonstrates six types of political action that took place that caused an electronic commerce (e-commerce) project to be abandoned. Finally, when analyzing mistakes and their principal causes, there is one important lesson that we should learn. That is, all organizations make mistakes and there is the potential for learning from project abandonment experiences.     

Internal Relative Price Stationarity in Long-Run Purchasing Power Parity

This study demonstrates that the joint relationship among domestic traded-goods prices, dometic nontraded-goods prices, foreign traded-goods prices, and foreign nontraded-goods prices is important to understanding rejections or confirmations of long-run PPP. This joint relationship is defined as the "cross-country internal relative price structure." For nine of the ten pairs of countries studied, the cross-country internal relative price structure is found to be stationary; thus, factors other than the influence of nontraded-goods prices must be responsible for the rejections of long-run PPP.