In a post-divorce equilibrium under joint legal custody of a child the paper compares the effect of two different transfer schemes, a general purpose transfer scheme and a specific purpose transfer scheme, from non-custodial parent to the custodial parent of the child on his/her welfare. Surprisingly, it finds that the marginal effects are neutral. The result contributes to the policy framework by suggesting that the lawyers/courts can choose the two alternatives equivalently in settling the child custody cases in a post-divorce situation. The paper also characterizes such transfer schemes and proves that the schemes can never restore the child’s welfare at the ‘happy marriage’ equilibrium level.
The most valuable asset of a professional service firm is its people. Owing to the high labor turnover, staffing decision
is very critical in its operations. We take engineering consultancy as a professional service and emphasize the importance
of developing knowledge stock of skilled consultants in a planned manner for efficient productivity management. Our focus
is management of knowledge-mix, which is the mix of consultants at different productivity levels. Our model is designed to
determine the steady-state number of consultant-mix to meet demand at a desired service level. This is done through the use
of control theory and chance constrained programming.
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Aims: Guidelines recommend prophylaxis with granulocyte colony-stimulating factor for chemotherapy-induced (febrile) neutropenia (CIN/FN) based on regimen myelotoxicity and patient-related risk factors. The aim was to conduct a cost-efficiency analysis for the US of the direct acquisition and administration costs of the recently approved biosimilar filgrastim-sndz (Zarxio EP2006) with reference to filgrastim (Neupogen), pegfilgrastim (Neulasta), and a pegfilgrastim injection device (Neulasta Onpro; hereafter pegfilgrastim-injector) for CIN/FN prophylaxis.Methods: A cost-efficiency analysis of the prophylaxis of one patient during one chemotherapy cycle under 1–14 days’ time horizon was conducted using the unit dose average selling price (ASP) and Current Procedural Terminology (CPT) codes for subcutaneous prophylactic injection under four scenarios: cost of medication only (COSTMED), patient self-administration (SELFADMIN), healthcare provider (HCP) initiating administration followed by self-administration (HCPSTART), and HCP providing full administration (HCPALL). Two case studies were created to illustrate real-world clinical implications. The analyses were replicated using wholesale acquisition cost (WAC).Results: Using ASP?+?CPT, cost savings achieved with filgrastim-sndz relative to reference filgrastim ranged from $65 (1?day) to $916 (14 days) across all scenarios. Relative to pegfilgrastim, savings with filgrastim-sndz ranged from $834 (14 days) up to $3,666 (1?day) under the COSTMED, SELFADMIN, and HPOSTART scenarios; and from $284 (14 days) up to $3,666 (1?day) under the HPOALL scenario. Similar to the cost-savings compared to pegfilgrastim, filgrastim-sndz achieved savings relative to pegfilgrastim-injector: from $834 (14 days) to $3,666 (1?day) under the COSTMED scenario, from $859 (14 days) to $3,692 (1?day) under SELFADMIN, from $817 (14 days) to $3,649 (1?day) under HPOSTART, and from $267 (14 days) to $3,649 (1?day) under HPOALL. Cost savings of filgrastim-sndz using WAC?+?CPT were even greater under all scenarios.Conclusions: Prophylaxis with filgrastim-sndz, a biosimilar filgrastim, was associated consistently with significant cost-savings over prophylaxis with reference filgrastim, pegfilgrastim, and pegfilgrastim-injector, and this across various administration scenarios. 相似文献
We address the scheduling problem with the following characteristics: (i) there is a single machine available, (ii) the machine has limited capacity, and (iii) job value deteriorates with time. The problem is motivated from several real world situations, such as, downloading process of web pages, and scheduling of multiplexes. Since the problem is NP-hard, we propose new heuristics based on a multiplicative piece-wise metric as an approximation of the slope of job value deterioration. Computational results show that the proposed heuristics perform better than other existing heuristics for similar types of problems. 相似文献
This research presents a retail shelf-space decision model that incorporates a nonlinear profit function, vertical and horizontal location effects, and product cross-elasticity. We propose a linear programming formulation of the nonlinear profit function that can solve the shelf-space problem optimally. We describe potential advances in heuristic and meta-heuristic algorithms and compare the approaches through simulations and a field experiment. We discuss the impact of the number of item facings, vertical location, and horizontal location (e.g., we find the vertical location effect is approximately double the size of the horizontal location effect on profit performance). 相似文献
The Federal Communications Commission is responsible for federal regulation in the telecommunications and electronic media sectors, and for management of the nation’s non-federal radio frequency spectrum. During the past year, Commission economists contributed to the agency’s ongoing efforts to use market-based mechanisms—such as auctions—to allocate spectrum and distribute universal service subsidies efficiently. This includes repurposing broadcast television spectrum for more efficient use by wireless service providers through the recently concluded Broadcast Incentive Auction and structuring auction mechanisms to promote efficient allocation of universal service subsidies for the increased build-out of mobile wireless and fixed broadband service in unserved and underserved areas. 相似文献