Comparative persistence and adherence with newer anti-hyperglycemic agents to treat patients with type 2 diabetes in the United States

Objectives: Non-adherence and non-persistence to anti-hyperglycemic agents are associated with worse clinical and economic outcomes in patients with type 2 diabetes. This study evaluated treatment persistence and adherence across newer anti-hyperglycemic agents (canagliflozin, dapagliflozin, sitagliptin, saxagliptin, linagliptin, liraglutide, or exenatide).

Methods: This retrospective cohort study of Truven Health Analytics Marketscan databases included adult patients with type 2 diabetes whose first pharmacy claim for a newer anti-hyperglycemic agent was between February 1, 2014 and July 31, 2014. Treatment persistence and adherence were assessed for 12 months after the first claim (post-index). Persistence was defined as no gap ≥90 days between the end of one pharmacy claim and the start of the next pharmacy claim post-index. Adherence used two definitions: proportion of days covered (PDC) and medication possession ratio (MPR). Multivariable analyses of non-persistence (hazard ratios) and adherence (odds ratios) were adjusted for baseline demographics, drug cost, clinical characteristics, and other anti-hyperglycemic agents.

Results: A total of 11,961 patients met all study selection criteria. Persistence rates at 12 months were significantly greater (p?p?=?0.83; PDC?=?0.79) and canagliflozin 300?mg (MPR?=?0.92; PDC?=?0.81) were greater than for the other index anti-hyperglycemic agents (MPR?=?0.33–0.75; PDC?=?0.33–0.72). Consistent results for treatment persistence and adherence were observed in multivariable analyses that were adjusted baseline characteristics.

Conclusions: Canagliflozin was associated with better treatment persistence and treatment adherence compared with other anti-hyperglycemic agents in real-world settings.     

Measuring misleading information in IPO prospectuses

Review of Quantitative Finance and Accounting - Newly public firms may provide misleading information about their business plans in their initial public offering (IPO) prospectuses. Using textual...     

Exploring how and when ethical conflict impairs employee organizational commitment: A stress perspective investigation

Previous studies demonstrate the detrimental effect of ethical conflict (i.e., incompatibility between ethical values of employees and organizations) on employee organizational commitment. However, few studies have assessed the underlying mechanisms and boundary conditions that may contribute to a deeper understanding of how and when the detrimental effect manifests. Drawing on the transactional model of stress and literature on the moral self, our study examines the psychological strain as a key intermediate mechanism that channels the negative relationship between the ethical conflict and organizational commitment. Furthermore, we posit that employees with different levels of moral identity and moral efficacy may suffer differently from ethical conflict. We tested our research model with two-wave lagged data obtained from 265 healthcare employees and found that the indirect, negative effect of ethical conflict on organizational commitment via psychological strain is strongest among employees with high moral identity and low moral efficacy. Interestingly, results show that employees with low moral identity and high moral efficacy do not suffer from ethical conflict. These findings suggest that ethical conflict is differentially harmful to employees and that a more nuanced understanding of its contingent effects is needed.     

录井施工作业中HSE管理体系的有效运行

HSE管理体系是一种体系化、规范化、科学化、制度化的管理方法,推行HSE管理体系是现代石油行业安全管理的先进模式,也是当前进入国际市场竞争的通行证。它是一种事前进行风险分析,确定其活动可能产生的危害和后果,从而采取有效的防范手段和控制措施防止其发生,以便减少可能引起的     

Optimal Exchange-Rate Policy in a Model of Local-Currency Pricing with Vertical Production and Trade

In this paper, we examine optimal exchange-rate flexibility in a model of local-currency pricing with vertical production and trade. Following a large body of empirical evidence, we assume that final-goods prices are sticky, but intermediate-goods prices are flexible. We find that, unlike what is found in the literature, optimal nominal exchange rate is flexible under local-currency pricing. The key element in deriving our conclusion is the difference in expenditure shares between home and foreign households. The conclusion holds even if the degrees of home bias in production are identical between home and foreign final-goods producers, which contrasts with the findings in the literature.     

How group efficacy mediates the relationship between group affect and identification

This study examines the mediating role of group efficacy on the relationship between group affect and group identification by integrating the collective cognition process. Using a sample of forty-seven work groups in Study 1, the results show that group efficacy fully mediates the relationship between positive and negative group affect and group identification. Study 2 applies a two-wave panel design to verify the impact of group efficacy on group identification. The results of Study 2 indicate that group efficacy relates positively to the development of group identification. The implications for theory and practice are discussed.     

“十二五”时期的金融发展与银行转型问题

分析了“十二五”时期国内外经济环境，论述了此环境下的金融发展与银行转型问题。     

KIBS企业—顾客交互创新中知识整合的权变机制

引入过程互依性和项目不确定性,探讨了KIBS企业-顾客交互创新中知识整合的权变机制。基于338份服务创新项目问卷数据进行实证研究,结果显示:在KIBS企业-顾客交互四要素中,除规则正式化负向影响外部知识整合以外,决策集体化、资源共享和任务协作均正向影响内、外部知识整合;过程互依性增强了规则正式化、决策集体化和任务协作对内部知识整合的影响,但对资源共享与内部知识整合间关系的调节作用不显著;项目不确定性增强了规则正式化、资源共享和任务协作对外部知识整合的影响,但对决策集体化与外部知识整合间关系的调节作用不显著。     

第三方支付机构的小企业融资业务发展浅析

借助第三方支付机构在银行和小企业之间的桥梁作用,可为小企业提供融资便利.本文对现有的融资模式进行了探讨,分析其积极作用和不足之处,在此基础上,对第三方支付机构以及监管部门在如何发展和保障小企业的融资业务方面提出了意见和建议.     

Capital reallocation: A tale of two frictions*

This paper explores the role of search and financial frictions in the used capital market. A tractable dynamic general equilibrium model with both frictions is developed to account for procyclicality of reallocation and the price of used capital. Both the aggregate productivity shock and the financial shock can generate procyclical reallocation of used capital. Quantitatively, the financial shock accounts for almost all the variation of used capital reallocation. The aggregate productivity shock is more responsible for the variation of the price of used capital as well as variables outside the used capital market.