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61.
Advergames are gaining recognition as a captivating environment. Although several flow models have determined online games usage, no previous model has explored determinants of positive attitudes toward advergames. The objectives included development and empirically testing of a model of flow experience and its determinants of attitudes toward advergames. Positive attitudes toward advergames were partially explained by the flow experience. The model revealed that challenges offered by the gameplay were an important predictor of flow, followed by telepresence and players’ skills. Contrary to expectations, arousal significantly impacted attitudes toward advergames but not flow. Implications for advertisers and web developers are discussed.  相似文献   
62.
Residents' attitudes towards an instant resort enclave   总被引:1,自引:0,他引:1  
Researchers have suggested that residents' attitudes towards tourism depend on the expected costs and benefits of tourism. While many studies have examined this proposition towards the later stages of development, few have examined the pre-tourism phase. This study used in-depth interviews with residents of Isabela, Puerto Rico, to examine their attitudes towards a proposed “instant” enclave resort in their community. At the time the research was conducted, Isabela was the planned site of the largest resort in the Caribbean. Results indicate that respondents are aware of both some of the positive and negative impacts of tourism, and are quite ambivalent about the planned tourist site.  相似文献   
63.
From the perspective of agency, resource‐based view, and resource‐dependence theories, we explore the impact of the presence of outside directors on firm performance in family small and medium‐sized enterprise (SMEs). Using survey data from 369 Spanish family SMEs, our findings show an inverted U‐shaped relationship between the proportion of outsiders on the boards of first‐ and second‐generation family firms and firm performance. The results show that a balanced presence of outside directors contributes to value creation in family SMEs and confirm that the composition and the roles of the board of directors differ from generation to generation in family firms.  相似文献   
64.
Recent publications have elevated the priority of increasing the integration of Science, Technology, Engineering, and Mathematics (STEM) content for K-12 education. The STEM education community must invest in the development of valid and reliable to scales to measure STEM content, knowledge fusion, and perceptions of the nature of STEM. This brief report discusses the development of an instrument to measure student perceptions of the interdependent nature of STEM content knowledge in the context of a complex classroom intervention implemented in five Colorado high schools (N = 275). Specifically, cross-functional science, technology, engineering, and mathematics teams of high school students were formed to complete engineering design problems. Exploratory (pretest) and confirmatory (posttest) factor analyses indicated that a newly adapted scale to measure student perceptions of the interdependent nature of STEM content knowledge had possessed adequate model fit. Furthermore, analysis revealed a novel pattern of results for the intervention. Specifically, students with initially high perceptions of the interdependent nature of STEM sustained their high perceptions at posttest; however, students with initially low perceptions exhibited statistically significantly positive gains from pretest to posttest. Therefore, this intervention may work best with students who are at risk of losing interest in STEM disciplines. The implications of these research findings are discussed.  相似文献   
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We have developed a generalised iterative scaling method (KRAS) that is able to balance and reconcile input–output tables and SAMs under conflicting external information and inconsistent constraints. Like earlier RAS variants, KRAS can: (a) handle constraints on arbitrarily sized and shaped subsets of matrix elements; (b) include reliability of the initial estimate and the external constraints; and (c) deal with negative values, and preserve the sign of matrix elements. Applying KRAS in four case studies, we find that, as with constrained optimisation, KRAS is able to find a compromise solution between inconsistent constraints. This feature does not exist in conventional RAS variants such as GRAS. KRAS can constitute a major advance for the practice of balancing input–output tables and Social Accounting Matrices, in that it removes the necessity of manually tracing inconsistencies in external information. This quality does not come at the expense of substantial programming and computational requirements (of conventional constrained optimisation techniques).  相似文献   
67.
The consequences of fatal and non-fatal road traffic injuries (RTI) at the personal and household levels were analysed using qualitative interviews of 12 injured and of 12 relatives of people who died for this reason. Collisions change physical and mental health both of the injured and of their relatives. This leads to changes in daily activities and even to the redefinition of future life. RTI also changes the way people see and act in life, becoming an experience that teaches them. Survivors commonly transmit a road safety message afterwards. Changes in family life were evident (in extreme cases family's composition also changed), affecting intra-familial relationships. Associated unexpected and unplanned expenditures and loss of income have consequences in the short, medium and long term that unbalance household's economies and immerse people into a constant stress. Individuals and family's future plans are occasionally condition to whether they have or not debts. Household dependence in economic terms was sometimes observed, as well as uncertainty about future life and household's sustainability. Sometimes, households change and adapt their life to what they now are able to afford, having important repercussions in vital spheres.  相似文献   
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69.
Objective Peginterferon beta-1a 125?mcg, administered subcutaneously (SC) every 2 weeks, a new disease-modifying therapy (DMT) for relapsing-remitting multiple sclerosis (RRMS), was approved by the US Food and Drug Administration in 2014. This study assesses the cost-effectiveness of peginterferon beta-1a vs interferon beta-1a (44?mcg SC 3 times per week) and glatiramer acetate (20?mg SC once-daily) in the treatment of RRMS from the perspective of a US payer over 10 years.

Methods A Markov cohort economic model was developed for this analysis. The model predicts disability progression, occurrence of relapses and other adverse events and translates them into quality-adjusted life years (QALYs) and costs. Natural history data were obtained from the placebo arm of the ADVANCE trial of peginterferon beta-1a, the London Ontario (Canada) database and a large population-based MS survey. Comparative efficacy of each DMT vs placebo was obtained from a network meta-analysis. Costs (in 2014?US dollars) were sourced from public databases and literature. Clinical and economic outcomes were discounted at 3% per year.

Results Over 10 years, peginterferon beta-1a was dominant (i.e., more effective and less costly), with cost-savings of $22,070 and additional 0.06 QALYs when compared with interferon beta-1a 44?mcg and with cost-savings of $19,163 and 0.07 QALYs gained when compared with glatiramer acetate 20?mg. Results were most sensitive to variations in the treatment effect of each DMT, treatment acquisition costs of each DMT and the time horizon. Probabilistic sensitivity analyses indicated that peginterferon beta-1a remains dominant in >90% of 5,000 replications compared with either DMTs.

Conclusion This analysis suggests that long-term treatment with peginterferon beta-1a improves clinical outcomes at reduced costs compared with interferon beta-1a 44?mcg and glatiramer acetate 20?mg and should be a valuable addition to managed care formularies for treating patients with RRMS.  相似文献   
70.
Capital inflows to some developing countries have increasedsharply in recent years. Impelled by better economic prospectsin those countries, lower international interest rates, anda slowdown of economic activity in the capital-exporting countries,the inflows have furnished financing much needed to increasethe use of existing capacity and to stimulate investment. Butcapital inflows can bring with them their own problems. Typicalmacroeconomic repercussions have been appreciation of the realexchange rate, expansion of nontradables at the expense of tradables,larger trade deficits, and, in regimes with a fixed exchangerate, higher inflation and an accumulation of foreign reserves. Should government intervene to limit some of these side effects—andif so, how? The question is especially pressing in the wakeof the Mexican crisis of December 1994. This article looks foranswers in the experience of four Latin American and five EastAsian countries between 1986 and 1993, examining the effectsof the capital inflows on the economy and comparing the differentways in which these countries responded to the problem of "toomuch" capital.   相似文献   
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