OPTIMAL FEEDING POLICIES FOR BROILER PRODUCTION: AN APPLICATION OF DYNAMIC PROGRAMMING*

The determination of an optimal feeding and selling strategy for broiler production given a space constraint is formulated as a dynamic programming problem. Production equations derived from trial data are used to obtain an optimal sequence of rations in which energy density changes through time. The stability of the plan is explored and the implications of the results for production research and commercial practice are considered.     

Appraising and paying for performance: another look at an age-old problem

The basic notion of improving performance through management and appraisal is difficult to successfully implement in practice. These authors discuss some of the problems presented by tying pay to performance appraisals, offer suggestions for improving performance appraisals and outline some other approaches for employers to consider in setting goals and determining compensation.     

A cost-effectiveness analysis of denosumab for the prevention of skeletal-related events in patients with multiple myeloma in four European countries: Austria,Belgium, Greece,and Italy

Aim: The approved indication for denosumab (120?mg) was expanded in 2018 to include skeletal-related event (SRE) prevention in patients with multiple myeloma (MM). Therefore, a cost-effectiveness analysis was conducted comparing denosumab with zoledronic acid (ZA) for SRE prevention in patients with MM from the national healthcare system perspective in a representative sample of European countries: Austria, Belgium, Greece, and Italy.

Methods: The XGEVA global economic model for patients with MM was used to calculate incremental cost-effectiveness ratios (ICERs) for denosumab vs ZA over a lifetime horizon. Clinical inputs were derived from the denosumab vs ZA randomized, phase 3 study (“20090482”) in patients newly-diagnosed with MM, and comprised real-world adjusted SRE rates, serious adverse event (SAE) rates, treatment duration, dose intensity, progression-free survival (PFS), and overall survival (OS). Economic inputs comprised country-specific denosumab and ZA acquisition and administration costs, SRE and SAE management costs, and discount rates. Health utility decrements associated with MM disease progression, SRE and SAE occurrence, and route of administration were included.

Results: Estimated ICERs (cost per quality-adjusted life-year [QALY] gained) for denosumab vs ZA in Austria, Belgium, Greece, and Italy were €26,294, €17,737, €6,982, and €27,228, respectively. Using 1–3 times gross domestic product (GDP) per capita per QALY as willingness to pay thresholds, denosumab was 69–94%, 84–96%, 79–96%, and 50–92% likely to be cost-effective vs ZA, respectively.

Limitations: Economic inputs were derived from various sources, and time to event inputs were extrapolated from 20090482 study data.

Conclusions: Denosumab is cost-effective vs ZA for SRE prevention in patients with MM in Austria, Belgium, Greece, and Italy, based on often-adopted World Health Organization thresholds. This conclusion is robust to changes in model parameters and assumptions. Cost-effectiveness estimates varied across the four countries, reflecting differences in healthcare costs and national economic evaluation guidelines.     

Developing a multiple-criteria decision analysis for green economy transition: a Canadian case study

ABSTRACT

Identifying planning strategies for the transition to a green economy is a formidable challenge. We proposed a novel multiple-criteria decision analysis model which can quantitatively identify the socio-economic and environmental impacts of various government and public policies. We applied the model to four practical scenarios in Canada for determining the optimal final demand that maximizes the country's GDP and employment while minimizing GHG emissions for small, short-term changes. As a result, the model suggested potential ways to simultaneously achieve a GDP growth of 2.5 billion CAD and creation of over 25,000 new jobs, and a saving of 2514 kt CO₂. As per the final demand, the electrification of domestic heating and transport should be more promoted. The proposed analysis tool will provide decision-makers with the ability to explore the design and effects of policy reforms, regulatory changes, and targeted public expenditure strategies, thereby overcoming barriers towards a green economy.     

Real exchange rates and U.S./Korean bilateral trade

This study examines the impacts of the real exchange rate on the bilateral trade between the U.S. and Korea using a highly disaggregated data set. In doing so, we estimate real exchange rate elasticity for 59 exported commodities （SITC two-digit classification） and 48 imported commodities （also SITC two-digit classification）. Furthermore, we classify commodities according to their attributes in order to examine whether commodity attributes influence the exchange rate elasticity of exports and imports. According to this study＇s results, there have been large changes across those commodities that are ranked as being top contributors to U.S. exports to and imports from Korea for the time periods before, during, and after the Korean financial crisis. Commodity attributes are shown to influence the exchange rate elasticity but are not always consistent with the a priori expectations.     

Multi-track financing

In today's uncertain economic environment, when seeking to finance a capital project, healthcare borrowers should adopt a multi-tracked funding strategy that permits them to change capital-funding routes quickly in response to changing circumstances. The multi-tracking process requires two stages prior to securing a commitment and beginning the closing process: due diligence and indication of interest. This process should present no material additional cost during these two stages, giving healthcare borrowers the flexibility to explore a variety of financing options.     

Entrepreneurship and limited access: rethinking business–state relations in Russia

Predominant theories of the Russian political economy explain the vulnerability of independent business to the state, but they do not adequately explain why businesses survive and some thrive. Recent empirical studies of business conditions have not helped in this regard because most focus on ascertaining entrepreneurs’ attitudes rather than observing their behaviour. During ethnographic fieldwork within a Siberian business, the author found that informants were pessimistic about business conditions, but that they did not expect any improvement and had developed pragmatic approaches to securing their position in the local market and competencies required to generate a profit. Their relations with dominant elites were, moreover, cordial rather than antagonistic. To account for these findings, the author draws on Douglass C. North et al.’s Limited Access Order theory and Aleksei Yurchak’s concept of ‘entrepreneurial governmentality’, and seeks to reconceptualise the relationship between business and the state.