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41.
Ana Clara Kneese Virgilio do Nascimento Joyce Maria Annichino-Bizzacchi Claudia de Alvarenga Maximo Eimy Minowa Guilherme Silva Julian 《Journal of medical economics》2017,20(8):884-892
Aims: Although several therapeutic options are available for chronic immune thrombocytopenic purpura (cITP), little is known about the treatment of cITP in Brazil.Materials and methods: A multi-center, retrospective chart review, observational study was designed to describe the treatment patterns, clinical burden, resources use, and associated costs for adult patients diagnosed with cITP and treated in public and private institutions in Brazil. Patient charts were screened in reverse chronological order based on their last visit post January 1, 2012. (All costs were calculated using 1.00 USD?=?3.9571 BRL, from February 2016.)Results: Of 340 patient charts screened, 50 patients were eligible for inclusion in the study. Single-drug therapy (prednisone, dexamethasone, or dapsone) was the most commonly used treatment, followed by combination therapies (azathioprine?+?prednisone, azathioprine?+?prednisone?+?danazol, and prednisone?+?dapsone). Splenectomy was performed in 22% of patients after at least first-line treatment. Platelet count and number of bleeding episodes at diagnosis were 31,561.1/mm3 (SD?=?±26,396.1) and 40 episodes, respectively; in first-line, 92,631.1/mm3 (SD?=?±79,955.3) and 19 episodes, respectively; in second-line, 96,950.0/mm3 (SD?=?±76,476.4) and 17 episodes, respectively. Private system patients had a higher median cost compared to public system patients (USD 17.49/month, range?=?0–2,020.77 vs USD 9.51/month, range?=?0–192.64, respectively).Limitations: This study does not allow conclusions for causal explanations due to the cohort study design, and treatment patterns represent only the practices of physicians who have agreed to participate in the study.Conclusions: The data indicate that available therapeutic strategies for second- and third-line therapies appear to be limited. 相似文献
42.
In this paper we give upper bounds for both the Value at Risk VaR α , 0 < α < 1 , and for ruin probabilities associated with the supremum of a process driven by a Brownian motion and a compound Poisson process. We obtain lower bounds for the same Value at Risk, and for different cases we discuss the behavior of the bounds for small α. We prove our bounds are "asymptotically" optimal, as α tends to zero. The ruin probabilities obtained are related to other bounds found in recent literature. 相似文献
43.
Effects of Collaborative Communication on NPD Collaboration Results: Two Routes of Influence 下载免费PDF全文
María Pemartín Ana I. Rodríguez‐Escudero José Luís Munuera‐Alemán 《Journal of Product Innovation Management》2018,35(2):184-208
Although NPD collaboration with external partners has become the next generation in NPD practice, the discussion concerning how to organize collaboration so as to obtain better results is far from over. Since communication is the most important element in successful interfirm exchange, this study focuses on the impact of collaborative communication and its facets—frequency, formality, reciprocal feedback, and rationality—on NPD collaboration results. In order to explain how collaborative communication can best be managed to enhance NPD collaboration results, this research combines the relational and resource‐based views, proposing the existence of two routes of influence: the direct resource‐based route and the indirect relational route mediated by trust. Using a sample of 207 NPD collaboration projects of innovative firms, empirical findings indicate that reciprocal feedback–rationality and frequency play an important role in product quality and adherence to budget and schedule, respectively, even without trust. Moreover, the trust between partners substantially reinforces the positive influence of reciprocal feedback–rationality on NPD collaboration results and makes the effect of formality significant. Therefore, the two alternative routes are confirmed as important paths to new product success, which provides relevant managerial implications. 相似文献
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45.
Although there are no traditional markets and money prices inthe public sector, consumers and providers may respond to signalsof organisational performance. We present a simple dynamic modelof the demand and supply for elective surgery in the UK NationalHealth Service in which waiting time acts as the prime indicatorof performance. The model is tested using a panel of quarterlydata for 123 English health authorities over an eight-year period.We find that supply is increasing and demand is decreasing inmeasures of the previous period waiting time. The results implythat health care systems which are rationed by waiting do respondto indicators of waiting times. The paper adds to the smallbut consistent body of research which demonstrates that publicsector systems respond to important aspects of reported performance. 相似文献
46.
Juan Bautista Delgado‐García Ana Isabel Rodríguez‐Escudero Natalia Martín‐Cruz 《Journal of Small Business Management》2012,50(3):408-428
Emotions are important to an individual's behavior. However, affective elements have rarely been included in the analysis of entrepreneurs' behavior. Using a sample of 335 entrepreneurs from multiple industries of the Spanish region of Castile and León, we analyze the role of emotions in entrepreneurs' statement of goals and in their satisfaction with business performance. The results show that positive affective traits influence an entrepreneur to state broad and ambitious goals, and personal negative affective traits influence an entrepreneur to state a narrow set of goals. We also find that positive (negative) affective traits are positively (negatively) related to entrepreneur satisfaction. 相似文献
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48.
Ana Paula Serra 《European Financial Management》1999,5(2):165-202
This paper examines the effects on stock returns of dual-listing on an international exchange. My sample consists of 70 firms from 10 emerging markets that dual-listed on the NYSE, NASDAQ and SEAQ-I (London) over the period 1991–1995. I evaluate whether an international dual-listing has any significant effect on returns, for the particular case of emerging markets' firms, and I proceed to investigate whether there is evidence to support an International Asset Pricing based explanation. In addition I compare the impact of US and London SEAQ-I listings. My results confirm previous empirical findings on international listings: the firms in my sample experience significant positive abnormal returns before listing and a significant decline in returns following listing. Evidence seems to be supportive of the segmentation hypothesis: dual-listing effects are more pronounced for emerging markets' listings and that pattern is similar across exchanges.
G15 相似文献
G15 相似文献
49.
Moshe Eben-Chaime Avital Bechar Ana Baron 《International Journal of Production Economics》2011,134(1):246-254
This paper offers mutual exchange of knowledge and expertise between agriculture and production-economy by economical evaluation of greenhouses. Greenhouses are Hi-Tech horticulture farms, in which advanced technological infrastructure increase production efficiency by providing optimal growing conditions. However, this infrastructure involves high capital investments. There are other cost sources, of which labor is dominant, generally in horticulture and in greenhouses in particular. Efficient use of space and labor are often conflicting goals in greenhouse layout design. In this paper, these conflicts are presented and illustrated, and tools are developed to evaluate layout design by the resultant annual operational profit, thus enable comparison of alternative layouts. To increase accessibility, spreadsheet software is used for the calculations. Further, the spreadsheet is designed to support WHAT-IF analyses. The applicability of the proposed approach is demonstrated via numerical analyses of layout design of an actual greenhouse for pepper growing using the Holland method. Evidently, the layout design can have significant effect on the economical efficiency of the greenhouse—annual profit increases by, at least 12%, and up to 40%! The tradeoff between space utilization and resource utilization; e.g., labor, is common to all greenhouses, whether vegetables, flowers or other plants are grown in them and the tools presented herein can be easily modified to any desired case. 相似文献
50.
We show how vicious circles in countries' credit histories arise in a model where output persistence is coupled with asymmetric information about output shocks. In such an environment, default signals the borrower's vulnerability to adverse shocks and creates a pessimistic growth outlook. This translates into higher interest spreads and debt servicing costs relative to income, raising the cost of future repayments, thereby creating “default traps”. We build a long and broad cross-country dataset to show the existence of a history-dependent “default premium” and of significant effects of output persistence on sovereign creditworthiness, consistent with the model's predictions. 相似文献