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11.
Ana Clara Kneese Virgilio do Nascimento Joyce Maria Annichino-Bizzacchi Claudia de Alvarenga Maximo Eimy Minowa Guilherme Silva Julian 《Journal of medical economics》2017,20(8):884-892
Aims: Although several therapeutic options are available for chronic immune thrombocytopenic purpura (cITP), little is known about the treatment of cITP in Brazil.Materials and methods: A multi-center, retrospective chart review, observational study was designed to describe the treatment patterns, clinical burden, resources use, and associated costs for adult patients diagnosed with cITP and treated in public and private institutions in Brazil. Patient charts were screened in reverse chronological order based on their last visit post January 1, 2012. (All costs were calculated using 1.00 USD?=?3.9571 BRL, from February 2016.)Results: Of 340 patient charts screened, 50 patients were eligible for inclusion in the study. Single-drug therapy (prednisone, dexamethasone, or dapsone) was the most commonly used treatment, followed by combination therapies (azathioprine?+?prednisone, azathioprine?+?prednisone?+?danazol, and prednisone?+?dapsone). Splenectomy was performed in 22% of patients after at least first-line treatment. Platelet count and number of bleeding episodes at diagnosis were 31,561.1/mm3 (SD?=?±26,396.1) and 40 episodes, respectively; in first-line, 92,631.1/mm3 (SD?=?±79,955.3) and 19 episodes, respectively; in second-line, 96,950.0/mm3 (SD?=?±76,476.4) and 17 episodes, respectively. Private system patients had a higher median cost compared to public system patients (USD 17.49/month, range?=?0–2,020.77 vs USD 9.51/month, range?=?0–192.64, respectively).Limitations: This study does not allow conclusions for causal explanations due to the cohort study design, and treatment patterns represent only the practices of physicians who have agreed to participate in the study.Conclusions: The data indicate that available therapeutic strategies for second- and third-line therapies appear to be limited. 相似文献
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Stefano Comino Alberto Galasso Clara Graziano 《The Journal of industrial economics》2020,68(2):226-269
This paper exploits the introduction of the first regularized patent system, which appeared in the Venetian Republic in 1474, to examine the factors shaping inventors’ propensity to use a new form of intellectual property. We combine detailed information on craft guilds and patents in Renaissance Venice and show a negative association between patenting activity and guild statutory norms that strongly restricted entry and price competition. Our analysis shows that the heterogeneity in patenting activity documented by the industrial organization literature is not a special feature of modern technologies, but is rather a persistent phenomenon affected by market power. 相似文献
13.
Bargaining one-dimensional social choices 总被引:1,自引:0,他引:1
We analyze bargaining over the one-dimension characteristic of a public good among n impatient players when decisions require q favorable votes, q?2. Stationary subgame perfect equilibrium strategies are characterized for all games with deterministic protocol. We provide a monotonicity condition (satisfied by all single-peak, strictly quasi-concave and concave utilities) that assures uniqueness for every q whenever player's utilities are symmetric around the peak. Without symmetry, the monotonicity condition assures uniqueness for qualified majorities, q>n/2, provided that agents are sufficiently patient and utilities satisfy an additional regularity condition. Asymptotic uniqueness is assured for qualified majorities by imposing only the monotonicity condition. 相似文献
14.
In the context of regularly varying tails, we first analyze a generalization of the classical Hill estimator of a positive tail index, with members that are not asymptotically more efficient than the original one. This has led us to propose alternative classical tail index estimators, that may perform asymptotically better than the Hill estimator. As the improvement is not really significant, we also propose generalized jackknife estimators based on any two members of these two classes. These generalized jackknife estimators are compared with the Hill estimator and other reduced-bias estimators available in the literature, asymptotically, and for finite samples, through the use of Monte Carlo simulation. The finite-sample behaviour of the new reduced-bias estimators is also illustrated through a practical example in the field of finance. 相似文献
15.
Carlos León Clara Machado Andrés Murcia 《International Journal of Intelligent Systems in Accounting, Finance & Management》2016,23(1-2):121-153
Three metrics are designed to assess Colombian financial institutions' size, connectedness and non-substitutability as the main drivers of systemic importance: (i) centrality as net borrower in the money market network; (ii) centrality as payments originator in the large-value payment system network; and (iii) asset value of core financial services. An aggregated systemic importance index is calculated based on expert knowledge by using a fuzzy logic inference system. We use principal component analysis to calculate a benchmark index for comparison purposes. Overall similarities between both indexes put forward that expert knowledge aggregation is consistent with that based on a purely quantitative standard approach. Specific non-negligible differences concur with the nonlinear features of an approach whose intention is to replicate human reasoning. Both indexes are complementary and provide a comprehensive relative assessment of each financial institution's systemic importance in the Colombian case, in which the choice of metrics pursues the macroprudential perspective of financial stability. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
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Existing studies using low-frequency data have found that macroeconomic shocks contribute little to international stock market covariation. However, these papers have not accounted for the presence of asymmetric information where sophisticated investors generate private information about the fundamentals that drive returns in many countries. In this paper, we use a new microstructure data set to better identify the effects of private and public information shocks about U.S. interest rates and equity returns. High-frequency private and public information shocks help forecast domestic money and equity returns over daily and weekly intervals. In addition, these shocks are components of factors that are priced in a model of the cross-section of international returns. Linking private information to U.S. macroeconomic factors is useful for many domestic and international asset-pricing tests. 相似文献
18.
Growth dynamics are remarkably heterogeneous, in particular when one focuses on developing countries. Economic miracles and failures are embedded within extended phases of either growth or decline. In this paper, we analyze the growth patterns of developing and newly industrialized countries on the basis of structural breaks and growth regimes experienced. Emphasizing the presence of broken trends, we focus on the difference between expansionary and recessionary regimes of medium length, and we show that models of takeoffs and exponential growth are inadequate to characterize the majority of observed growth dynamics. Then, we move to a systematic classification of different patterns and we isolate an additional stylized fact characterizing the process of growth and development. In particular, our results show that expansionary regimes are associated with convergence and positive correlation between growth and (short run) volatility. By contrast, in recessionary regimes, poorer countries face deeper failures and a negative correlation between growth and volatility is found, indicating that output fluctuates less around the trend during strong rather than mild recessions. Catching-up phenomena are infrequent but more likely to occur across categories of growth patterns rather than within. Finally, we discover that regimes of growth and recession show similar average length (about 16 years). Although recessions are, on average, remarkably pronounced (14% loss of GDP per capita), the magnitude of growth is much larger during expansions. In sum, our results underline that stable positive growth is hardly achieved in developing countries, which rather alternate long phases of expansions with equally long phases of recession. Moreover, cross-sectional empirical regularities are found to differ between regimes of positive and negative growth. 相似文献
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Previous studies suggest that entrepreneurs play a key role in the success of their ventures. But relatively little is currently known about how they produce such effects. The present research provides data suggesting that two modes of entrepeneurs’ self‐regulation—locomotion and assessment—enhance a firm's success through their effects on the components of alertness. This mediational model was tested and supported with data from 120 entrepreneurs. Locomotion was positively related to the scanning and search component, while assessment was positively related to the association and evaluation components. These findings are discussed in terms of the role of founders’ self‐regulation in the performance of their companies. 相似文献