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831.
Convergence among regions is explicitly defined as a political aim of the European Union. Overall, NUTS3 regions have indeed shown a path of convergence since the year 2000, but there are huge differences among the regions. Many Eastern European countries as well as several regions in Spain and Portugal are characterised by a convergence process. However, the opposite holds for many regions in Greece, Italy and the UK. The size of a region’s manufacturing is important for the process of convergence, and the direction of subsidies from the EU to the right fields of activity also has a positive influence on the probability of a region to converge.  相似文献   
832.
After the Brexit referendum’s leave outcome last summer, the new relationship between the UK and the EU has to be shaped institutionally. For the two bargaining parties the question now is which negotiation strategy to take. In order to choose the optimal strategy, the players have to factor in their time preferences. A game theoretical approach yields that the EU — no matter what is economically feasible in the short run — has to play a tough negotiation strategy if they care about the long run. This result is not a question of punishment but of pure economic rationale.  相似文献   
833.
对前苏联地区各国的政体变更的研究,常常陷于追逐该地区发生的各种政治事件中。这些研究经常假定政体变更,如果不是简单的不稳定,则意味要么是朝向民主体制要么是朝向专制制度变化。本文提出政体“周期”的理论(类似于经济周期),认为政体变更可能是循环性的,而不是简单的用进步、倒退或毫无规则等概念来定义。事实上,前苏联地区各国中,政体周期的现象非常常见。一些国家已经从专制制度向更加民主的制度转变,然后又回到更加专制的制度。随着最近发生的“颜色革命”,这些国家又向更加民主的方向转变。本文提出一个政治精英集体行动的制度主义逻辑,集中关注“大佬总统制”在其中的作用,十分有助于我们理解这种政体周期的规律。这一概念也有助于解释为什么2003年到2005年之间,乌克兰、格鲁吉亚、吉尔吉斯斯坦等国发生了“颜色革命”,而俄罗斯、阿塞拜疆和乌兹别克斯坦等国则未发生。  相似文献   
834.
This paper shows that unit taxation can be welfare superior to ad valorem taxation in asymmetric and differentiated oligopolies if the goods are sufficiently differentiated, the cost variance is sufficiently large and the ad valorem tax rate is sufficiently high. Moreover, this result holds under either Cournot competition or Bertrand competition.   相似文献   
835.
This cross‐country study documents policies and practices designed to increase women entrepreneurs’ access to financial capital in Canada, Germany, Ireland, Norway, and the United States. Drawing on feminist theory, we examine assumptions of policy alongside the eligibility criteria, rules and regulations of practices. Our findings reveal that four of the five country policies examined were predicated on a neo‐liberal perspective that positions women entrepreneurs as economic assets. We offer insights into opportunities for modernizing policies and practices in ways that will enhance the legitimacy of a more diverse array of women entrepreneurs and increase their access to financial capital.  相似文献   
836.
This article responds to the points raised by Daniel P. Aldrich, Emily Chamlee-Wright, and Lori Peek in the symposium on our book Community Revival in the Wake of Disaster: Lessons in Local Entrepreneurship (Palgrave Macmillan, 2015).  相似文献   
837.
Aims: Prophylaxis with recombinant factor VIII (rFVIII) is the standard of care for severe hemophilia A in Sweden. The need for frequent injections with existing rFVIII products may, however, result in poor adherence to prophylaxis, leading to increased bleeding and long-term joint damage. Recombinant FVIIIFc (rFVIIIFc) is an extended half-life fusion protein which can offer prolonged protection and reduced dosing frequency. The objective of this study was to evaluate the cost-utility of prophylaxis with rFVIIIFc in severe hemophilia A from the perspective of the Swedish health system.

Methods: A Markov model was built to estimate lifetime costs and benefits of prophylaxis with rFVIIIFc vs rFVIII products. Clinical outcomes were represented by annualized bleeding rate (ABR) and quality of life via disutility applied to bleeding events and injection frequency. Costs included the cost of FVIII for routine prophylaxis and bleed resolution. The pooled comparator was costed by weighting the cost of individual products by their market share.

Results: In the base case, rFVIIIFc was dominant vs the pooled comparator. Savings of SEK 9.0 million per patient resulted from lower factor consumption for prophylaxis and bleed resolution. Fewer bleeds and reduced injection frequency yielded an estimated 0.59 quality-adjusted life years (QALYs). Results were sensitive to drug dosage and robust to variation in other parameters. Probabilistic sensitivity analysis suggested a greater than 85% probability of rFVIIIFc being cost-effective at a willingness-to-pay threshold of 500,000 SEK/QALY.

Limitations: Due to unavailibilty of patient-level data, treatment benefit was based on a non-adjusted indirect comparison. Dosing and treatment outcomes were assumed to persist over the model duration in the absence of long-term outcome data.

Conclusion: The results suggest that rFVIIIFc may be a cost-effective option for hemophilia A prophylaxis, generating greater quality of life and reduced costs for the Swedish payer compared to more frequently administered rFVIII alternatives.  相似文献   
838.
A general framework is given to analyze the falsifiability of economic models based on a sample of their observable components. It is shown that, when the restrictions implied by the economic theory are insufficient to identify the unknown quantities of the structure, the duality of optimal transportation with zero–one cost function delivers interpretable and operational formulations of the hypothesis of specification correctness from which tests can be constructed to falsify the model.  相似文献   
839.
Experience demonstrates that policies crafted to operate within a certain range of conditions are often faced with unexpected challenges outside of that range. The result is that many policies have unintended impacts and do not accomplish their goals. Adaptive policies are designed to function more effectively in complex, dynamic, and uncertain conditions. Based on over a dozen case studies on public policies relating to agriculture and water resources management in Canada and India, we conclude that there are seven tools policymakers should follow to create adaptive policies. Adaptive policies anticipate and plan for the array of conditions that lie ahead: (#1) using integrated and forward-looking analysis; (#2) monitoring key performance indicators to trigger built-in policy adjustments; (#3) undertaking formal policy review and continuous learning; and (#4) using multi-stakeholder deliberation. But not all situations can be anticipated. Unknown unknowns and deep uncertainty will always be part of policymaking. Adaptive policies are able to navigate toward successful outcomes in settings that cannot be anticipated in advance. This can be done by working in concert with certain characteristics of complex adaptive systems and thereby facilitating autonomous actions among stakeholders on the ground. To a degree, adaptive policy tools #3 and #4 can be used toward this purpose, but most directly, such autonomous tools include: (#5) enabling self-organization and social networking; (#6) decentralizing decisionmaking to the lowest and most effective jurisdictional level; and (#7) promoting variation in policy responses. This paper elaborates on these seven tools as a pragmatic guide for policymakers who find themselves working in highly complex, dynamic, and uncertain settings.  相似文献   
840.
In this paper, we present a general model of the joint data generating process underlying economic activity and stock market returns allowing for complex nonlinear feedbacks and interdependencies between the conditional means and conditional volatilities of the variables. We propose statistics that capture the long and short run responses of the system to the arrival of news, conditioning on the sign and time of arrival of the news. The model is applied to US data. We find that there are significant differences between the short and long run responses of economic activity and stock returns to the arrival of news. Moreover, for certain classifications of news, the respective responses of economic activity and stock returns vary according to the nature of the news and the phase of the business cycle at which the news arrives.  相似文献   
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