Electronic funds transfer as a subject of study in technology,society and public policy

As society becomes increasingly dependent upon technology, and so increasingly a subject of public policy scrutiny, it is essential to acquire as much knowledge as possible about technology development, adoption, use, and impacts. The authors propose in detail a long-term study of electronic funds transfer that would cover six major topics: how technology emerges; how new technology is handled by existing institutions; how new technologies are assimilated by the public; what specific impacts new technologies have; how new technologies create synergistic impacts with other technologies; and how technologies change over time to conform to new circumstances and developments. They conclude with a consideration of the measures necessary for the implementation of such a study.     

Cost-effectiveness of aripiprazole once-monthly compared with paliperidone palmitate once-monthly injectable for the treatment of schizophrenia in the United States

Objective:

To develop a decision-analytic model to estimate the cost-effectiveness of initiating maintenance treatment with aripiprazole once-monthly (AOM) vs paliperidone long-acting injectable (PLAI) once-monthly among patients with schizophrenia in the US.

Methods:

A decision-analytic model was developed to evaluate a hypothetical cohort of patients initiating maintenance treatment with AOM or PLAI. Rates of relapse, adverse events (AEs), and direct medical costs were estimated for 1 year. Patients either remained on initial treatment or discontinued treatment due to lack of efficacy, AEs, or other reasons, including non-adherence. Data from placebo-controlled pivotal trials and product prescribing information (PI) were used to estimate treatment efficacy and AEs. Analyses were performed assuming dosing of clinical trials, real-world practice, PIs, and highest therapeutic dose available, because of variation in practice settings. The main outcome of interest was incremental cost per schizophrenia hospitalization averted with AOM vs PLAI.

Results:

Based on placebo-controlled pivotal trials’ dosing, AOM improved clinical outcomes by reducing schizophrenia relapses vs PLAI (0.181 vs 0.277 per person per year [pppy]) at an additional cost of US$1276 pppy, resulting in an incremental cost-effectiveness ratio (ICER) of US$13,280/relapse averted. When PI dosing was assumed, this ICER increased to US$19,968/relapse averted. When real-world dosing and highest available dosing were assumed, AOM was associated with fewer relapses and lower overall treatment costs vs PLAI.

Conclusions:

AOM consistently provided favorable clinical benefits. Under various dosing scenarios, AOM results indicated fewer relapses at lower overall costs or a reasonable cost-effectiveness threshold (i.e., less than the cost of a hospitalization relapse) vs PLAI. Given the heterogeneous nature of schizophrenia and variability in treatment response, health plans may consider open access for treatments like AOM. Since model inputs were based on data from separate placebo-controlled trials, generalization of results to the real-world setting is limited.     

Climate Smart Agriculture? Assessing the Adaptation Implications in Zambia

We examine a set of potentially climate smart agricultural practices, including reduced tillage, crop rotation and legume intercropping, combined with the use of improved seeds and inorganic fertiliser, for their effects on maize yields in Zambia. We use panel data from the Rural Incomes and Livelihoods Surveys merged with a novel set of climatic variables based on geo‐referenced historical rainfall and temperature data to explore the changing effects of these practices with climatic conditions. We estimate the impacts on maize yields, and also on the exhibition of very low yields and yield shortfalls from average levels, as indicators of resilience, while controlling for household characteristics. We find that minimum soil disturbance and crop rotation have no significant impact on these yield outcomes, but that legume intercropping significantly increases yields and reduces the probability of low yields even under critical weather stress during the growing season. We also find that the average positive impacts of modern input use (seeds and fertilisers) are significantly conditioned by climatic variables. Timely access to fertiliser emerges as one of the most robust determinants of yields and their resilience. These results have policy implications for targeted interventions to improve the productivity and the resilience of smallholder agriculture in Zambia in the face of climate change.     

Inducing liquidity in thin financial markets through combined-value trading mechanisms

Asset pricing theory hypothesizes that investors are only interested in portfolios; individual securities are evaluated only in terms of their contribution to portfolio risk and return. Yet, standard financial market design is that of parallel, unconnected markets, whereby investors cannot submit orders in one market conditional on events in others. When markets are thin, this exposes them to substantial execution risk. Fear of ending up with unbalanced portfolios after trading may even keep investors from submitting orders, further eroding liquidity and the ability of markets to equilibrate. The suggested solution is a portfolio trading mechanism referred to as combined-value trading (CVT). Investors are allowed to submit orders for packages of securities and the system matches trades and computes prices by optimally combining portfolio orders in an open book. We study the performance of the CVT mechanism experimentally and compare it to the performance of parallel, unconnected double auctions in experiments with similar parametrization and either a similar number of subjects or substantially thicker markets. We present evidence that our portfolio trading mechanism facilitates equilibration to the extent that the thicker markets do. Inspection of order submission and trade activity reveals that subjects manage to exploit the direct linkages between markets enabled by the CVT system.     

Generalised weakened fictitious play

A general class of adaptive processes in games is developed, which significantly generalises weakened fictitious play [Van der Genugten, B., 2000. A weakened form of fictitious play in two-person zero-sum games. Int. Game Theory Rev. 2, 307–328] and includes several interesting fictitious-play-like processes as special cases. The general model is rigorously analysed using the best response differential inclusion, and shown to converge in games with the fictitious play property. Furthermore, a new actor–critic process is introduced, in which the only information given to a player is the reward received as a result of selecting an action—a player need not even know they are playing a game. It is shown that this results in a generalised weakened fictitious play process, and can therefore be considered as a first step towards explaining how players might learn to play Nash equilibrium strategies without having any knowledge of the game, or even that they are playing a game.