Converging scientific fields and new technological paradigms as main drivers of the division of scientific labour in drug discovery process: the effects on strategic management of the R&D corporate change

The thesis of this study is that the convergence of genetics, genomics and proteomics spurs new technological paradigms in medicine, which are generating a R&D corporate change: division of scientific labour of the drug discovery process by strategic alliances among firms in order to reinforce the integrative capabilities in different biomedical research fields and collective and cumulative learning between in-house R&D and external sources of innovation. This study shows, by key a case study of pharmaceutical companies, as scientific and technological paradigms in medicine are main drivers of industrial and R&D corporate change to enhance and accelerate the discovery process of ground-breaking drugs for more and more personalised healthcare.     

Linking learning with governance in networks and clusters: key issues for analysis and policy

In this paper we analyse the relationship between governance and learning in clusters and networks. In particular, we see these two key elements as interdependent, suggesting that, under particular circumstances, such interdependence may drive clusters and networks towards a dynamic development trajectory. A pure ‘governance perspective’ makes the development of any locality dependent on the system of powers which exists within the locality or across the global value chain. In parallel, a pure ‘competence-based approach’ focuses mainly on the capabilities of actors to learn and undertake activities. In contrast, we open the prospects for an interdependent relation that may change the actual competences of actors as well as the governance settings and dynamics in networks and clusters. When supported by public policies, the learning process may have the potential to modify the governance environment. Simultaneously, the learning process is intrinsically influenced by economic power, which may seriously affect the development prospects of clusters and networks. This is why an intertwined consideration of both aspects is necessary to promote specific approaches to learning and to design appropriate policies. In this paper we offer two preliminary case studies to clarify some of these dynamics: the first taken from the computers cluster in Costa Rica and the second from an Italian bio-pharmaceutical firm and its production network. The first case study refers to the software cluster that was created from scratch in Costa Rica thanks to an enlightened government policy in coordination with new local enterprises and an important foreign direct investor; while the second reflects on the ability of an individual company to create a network of relationships with large transnational companies in order to acquire new competences without falling into a subordinate position with respect to its larger partners.     

Choosing sides in the trilemma: international financial cycles and structural change in developing economies

ABSTRACT

This paper analyzes the impact of international financial cycles on structural change in developing economies. It is argued that the impact of these cycles depends on the specific combination of macroeconomic and industrial policies adopted by the developing economy. The cases of Brazil and Argentina are contrasted with those of Korea and China. In the Asian economies, macroeconomic policy has been a complementary tool along with industrial policy to foster the diversification of production and capabilities. Inversely, in the case of the Latin American countries, long periods of real exchange rate (RER) appreciation, combined with the weaknesses (or absence) of industrial policies, contributed to the loss of capabilities and lagging behind.     

Rationale and policies for the green growth of cities and regional economies

By linking environmental quality to economic growth, green growth is emerging as a new paradigm for urban policies. The paper discusses a policy package for green growth of cities and regional economies, made of four interlocking pillars: a) greener public services and purchasing behavior, b) eco-efficiency of industrial production, c) consumer awareness and demand incentives, d) support for research and innovative applications of green technologies. Urban green growth strategies are more likely to succeed if they account for policy interventions in each of these four domains. Prioritization among the different interventions needs to be based on an accurate screening of possible complementarities among the four pillars. Within the strategy, interventions in one domain unlock positive developments in other domains. Synergies and possibilities for leverage do exist at the local level, as well as potentials for policy experimentation. More knowledge of how the local economy works and a strong capacity to pursue interdepartmental and multi-level programs are essential requisite to seize the employment and growth potentials of the low-carbon transition.     

Ago\ra Partnerships Nicaragua: A micro venture capital fund

Agora Partnerships is a micro venture capital fund founded by Benjamin Powell in the US and Ricardo T. Teran in Nicaragua. Agora started operations in 2005 with the goal of identifying and supporting entrepreneurs and business plans with high potential for success. The fund faces some unique challenges. First, the size of the businesses that is investing in does not allow for a traditional “management fee” structure. Secondly, traditional investment exits are nearly impossible in Nicaragua. This teaching case includes analysis on sources of investment capital, deal structures, and expected returns. The unresolved dilemma remains how to structure an investment proposal attractive to both investors and entrepreneurs. The case also allows discussing how to adapt the venture capital model to an emerging country like Nicaragua.     

Earthquake effects on tourism in central Italy

This paper proposes an approach to economic assessment of the impact on tourist flows of the earthquake that hit the Umbria region in Central Italy on September 26, 1997. Local arrivals in Assisi fell drastically the month following the main shock, compared to the same month of the previous year. The event study methodology, frequently applied in finance, is employed to evaluate the statistical relevance of the shock over time and space. A further and straightforward application of the event study analysis assesses the substantial amount of loss between October 1997 and June 1998 due to the drop of tourism business.     

Shopping value,tourist satisfaction and positive word of mouth: the mediating role of souvenir shopping satisfaction

We propose new insights into key satisfaction outcomes for souvenir retailers, such as positive word-of-mouth recommendations, seeking deeper comprehension of overall tourist satisfaction determinants, by analysing the mediating role of tourist souvenir shopping satisfaction. We apply variance-based structural equation modelling by means of partial least squares to a sample of 408 tourists all of whom had purchased souvenirs. The results suggest that tourist shopping satisfaction partially mediates the relation between shopping value and positive word of mouth, while tourist shopping satisfaction completely mediates the relation between shopping value and overall tourist satisfaction. The results and their implications are then discussed to arrive at pertinent conclusions on tourist souvenir shopping satisfaction.     

Bounds on the estimation error in the chain ladder method

Buchwalder et al. (2006) have illustrated that there are different approaches for the derivation of an estimate for the parameter estimation error in the distribution-free chain ladder reserving method. In this paper, we demonstrate that these approaches provide estimates that are close to each other for typical parameters. This is carried out by proving upper and lower bounds.