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891.
Jacqueline Nicholas Rachel Halpern Marina Ziehn Jesse Peterson-Brandt Michael Leszko 《Journal of medical economics》2020,23(8):885-893
AbstractAims: The study evaluated the real-world cost of treatment in multiple sclerosis (MS) patients initiating infused disease-modifying-therapies (DMT) in the United States.Materials and Methods: This retrospective cohort study using administrative claims data included adult patients with MS initiating index infusion DMT (ocrelizumab (OCR), natalizumab (NTZ) or alemtuzumab (ATZ)) from April 2017–September 2018 with 6-months pre/12-months post-index continuous enrollment. The primary cohort included patients who had prescribed annual dosing visits indicated by the approved product label (PL): 3 OCR, 5 ATZ, and 12–13 NTZ infusion visits within the first year of initiation. Annual treatment cost was the sum of all costs on index DMT infusion visit dates. Costs were summarized for a primary and secondary cohort of patients receiving additional doses than prescribed in PL (>3 OCR, >5 ATZ, and >13 NTZ infusion visits); and an overall cohort of patients who met minimum required annual dose (≥3 OCR, ≥5 ATZ, and ≥12 NTZ), further stratified by insurance type.Results: For patients in the primary cohort (123 OCR, 18 ATZ, and 48 NTZ), mean (standard-deviation) annual cost of treatment with OCR, ATZ, and NTZ cohorts was $72,066 ($34,480), $121,053 ($51,097) and $93,777 ($38,815), respectively. Among patients initiating OCR and NTZ, 15 and 6% respectively, had additional infusion visits leading to greater costs. Mean annual costs of index infusion DMT treatment in the overall cohort (162 patients treated with OCR, 18 with ATZ, 56 with NTZ) were $80,582, $121,053, and $93,807, respectively. The mean costs for commercial enrollees were higher than those for MAPD enrollees.Limitations: Small sample size, limited population generalizability, and cost-reduction for ATZ beyond the second year need to be accounted for.Conclusions: Real-world infusion DMT treatment costs for commercially insured patients were higher than perceived expenditures based on wholesale acquisition cost and administration costs via a physician-fee schedule. Consideration of real-world costs in cost-effectiveness and treatment/coverage decisions is needed. 相似文献
892.
Nicholas Apergis Christina Christou Rangan Gupta Stephen M. Miller 《International Advances in Economic Research》2018,24(2):147-161
This paper contributes to the sparse literature on inequality convergence by empirically testing convergence across states in the U.S. This sample period encompasses a series of different periods that the existing literature discusses -- the Great Depression (1929–1944), the Great Compression (1945–1979), the Great Divergence (1980-present), the Great Moderation (1982–2007), and the Great Recession (2007–2009). This paper implements the relatively new method of panel convergence testing, recommended by Phillips and Sul (2007). This method examines the club convergence hypothesis, which argues that certain countries, states, sectors, or regions belong to a club that moves from disequilibrium positions to their club-specific steady-state positions. We find strong support for convergence through the late 1970s and early 1980s, and then evidence of divergence. The divergence, however, moves the dispersion of inequality measures across states only a fraction of the way back to their levels in the early part of the twentieth century. 相似文献
893.
Jane Cameron Barbara Nicholas Katherine Silvester Karen Cronin 《Technology Analysis & Strategic Management》2013,25(3):271-285
New Zealand's ‘Navigator Network’ is a national scanning network of scientists and policy analysts providing ‘early alert’ advice about emerging areas of science and technology. It was established by the Ministry of Research, Science and Technology (MoRST) to enhance the government's readiness to respond to the opportunities and risks around new technologies, particularly in biotechnology and nanotechnology. The Navigator Network has been tailored to the New Zealand context, which is characterised by a small, well-connected government sector and a strong focus on agricultural biotechnology and food. The network builds on these features, and is ‘people-centric’ rather than ‘information-centric’, using dialogic approaches to generate new knowledge between diverse stakeholder groups. It also focuses on building futures capability in the government and science sectors. Representatives from government agencies are integrated into the process as scanners to facilitate uptake. It also has an adaptive development process via an action learning component. 相似文献
894.
Spatially disaggregated maps of the incidence of poverty can be constructed by combining household survey data and census data. In some countries (notably China and India), national statistics agencies are reluctant, for reasons of confidentiality, to release household‐level census data, but they are generally more willing to release aggregated census data, such as village‐ or district‐level means. This paper examines the loss in precision associated with using aggregated census data instead of household‐level data to generate poverty estimates. The authors show analytically that using aggregated census data will result in poverty rates that are biased downward (upward) if the rate is below (above) 50%, and that the bias approaches zero as the poverty rate approaches zero, 50%, and 100%. Using data from Vietnam, it is found that the mean absolute error in estimating district‐level poverty rates is 2.5 percentage points if the census data are aggregated to the enumeration‐area level means, and 3–4 percentage points if the data are aggregated to commune or district level. Finally, the authors propose a method for reducing the error using variances calculated from the census. When this approach is applied to the Vietnam data, this method can cut the size of the aggregation errors by around 75%. 相似文献
895.
In this paper we show how the potential misspecification of the consumption function can be ameliorated by approximating
any unmodelled long run variation with an unobserved component in the form of a time-varying trend. This methodology is applied
to Greek, Portuguese and Spanish consumption functions during the post-second World war period. The empirical evidence suggests
that there are many determinants of long-run consumption in these countries, in addition to income and inflation, and these
unobserved long-run effects are captured by a nonstationary stochastic component. The long-run elasticity of consumption with
regards to the unobserved component is greater than unity in all countries.
First version received: January 1999/Final version received: June 2000 相似文献
896.
This paper examines the information content of the equity risk factors that explain cross variation of stock returns and predicting future macroeconomic growth. For the first time we incorporate a new foreign exchange risk factor, providing important insights into the relationship between risk factors and the business cycle. The methodology involves the performance of a stepwise regression analysis of future macroeconomic growth against the lagged returns of five risk factors (market risk premium, size, value, momentum and foreign exchange risk). The results are validated with Granger causality tests and out-of-sample dynamic forecasting. They show that the foreign exchange risk factor contains strong, stable and statistically significant incremental information concerning future macroeconomic growth. Firms that are sensitive to the foreign exchange risk thrive when an economic upturn is anticipated and firms that are insensitive to the foreign exchange risk will have larger returns when an economic downturn is anticipated. 相似文献
897.
Policies to promote research and development (R&D) are high on the government's agenda. R&D and innovation are seen as key drivers of economic growth and important for raising UK productivity. This paper considers recent trends in UK R&D performance. We show that UK R&D is more internationalised than that of other G5 countries and is becoming increasingly so at a faster rate. A rising share of UK R&D is funded from abroad and UK firms are undertaking more of their R&D overseas. Using an international panel of countries, we show that R&D in one country responds to a change in the price in another ‘competitor’ country. This suggests that UK innovation policies could play an important role in determining whether increasingly footloose R&D locates in the UK or moves overseas. 相似文献
898.
Nicholas McClaren 《Journal of Business Ethics》2013,112(1):101-125
Research into ethics in personal selling and sales management has increased substantially over the preceding decade by investigating complex dimensions of ethical decision-making in greater depth and with more analytical sophistication. This review of the recent conceptual and empirical literature provides insight into the extent and the direction of this knowledge, recommends managerial action, and discusses areas for future exploration. Future direction is also provided through research propositions. The type of sales practitioner investigated, the main variables examined, and the key findings are summarized in an Appendix. 相似文献
899.
This paper analyzes the effects of extreme temperature on manufacturing output using a data set covering the universe of manufacturing establishments in Canada from 2004 to 2012. Extreme temperature can affect manufacturing activity directly through its impact on labour productivity and indirectly through a change in demand for products. Using a panel fixed effects method, our results suggest a non-linear relationship between outdoor extreme temperature and manufacturing output. Each day where outdoor mean temperatures are below °C or above 24 °C reduces annual manufacturing output by 0.18% and 0.11%, respectively, relative to a day with mean temperature between 12 ° and 18 °C. In a typical year, extreme temperatures, as measured by the number of days below °C or above 24 °C, reduce annual manufacturing output by 2.2%, with extreme hot temperatures contributing the most to this impact. Given the predicted change in climate for the mid- and end of century, we predict annual manufacturing output losses due to extreme temperature to range between 2.8% and 3.7% in mid-century and 3.7% and 7.2% in end of century. 相似文献