Costs of in-house genomic profiling and implications for economic evaluation: a case example of non-small cell lung cancer (NSCLC)

Abstract

Objectives

Genomic profiling in oncology is vital for determining eligible patients for mutation-specific targeted therapies. Use of commercial genomic testing has the potential to improve patient outcomes. Economic evaluations of in-house genomic profiling typically only include material costs while external commercial services include many other factors. Using non-small cell lung cancer (NSCLC) as an example, this study sought to characterize the unique challenges of costing testing services and their impact on results of economic evaluations.     

Quality as an autonomous body of knowledge. An in-depth survey on Italian higher education

The need of people skilled on quality topics is strongly increased in Italy, in the last 10 years, and new professional figures that are specialized in quality have been recently recognized by the Italian official classification of occupations. However, there seems to be a lack of empirical studies that analyse education about quality supplied by Italian universities and business schools. This paper shows the results of an exploratory survey on the education in quality offered by Italian universities. The research was conducted on a reasoned sample of Italian universities, selected on the basis of the number of students enrolled and the number of supplied degree courses, in the academic year 2005/2006. Thanks to the findings of the survey it is possible to know what (what subjects related to quality concepts and tools are taught), where (within which degree programs they are taught), and when (at which degree level they are taught) Italian higher education is devoted to quality.     

Exploring the determinants of digital entrepreneurship using fuzzy cognitive maps

In an increasingly digital world, almost anything can now be done through a computer or smartphone. Digital entrepreneurship is capitalizing on this trend, which brings numerous advantages to firms and society at large. However, the determinants of digital entrepreneurship’s success are still unclear, as well as how they relate to each other. This study sought to develop a fuzzy cognitive map (FCM) to identify and analyze the determinants of digital entrepreneurship. Two group sessions were held with a panel of decision makers who deal with the digital entrepreneurship phenomenon every day. Based on their shared experience and knowledge, an FCM was developed and validated for this research context. Static and dynamic analyses facilitated a deeper understanding of the cause-and-effect relationships between the determinants of digital entrepreneurship, resulting in a well-informed framework that was validated by the panel members. This methodological procedure enabled an objective analysis of the dynamics behind digital entrepreneurship. The advantages and limitations of our constructivist framework are also discussed.

     

The Consumption/Wealth and Book/Market Ratios in a Dynamic Asset Pricing Contex

This paper addresses new insights into the predictability of financial returns. In particular, we analyze two aspects of the controversial forecasting literature. On the one hand, we demonstrate a positive and contemporaneous link between aggregate book/market and consumption/wealth ratios. On the other hand, we show that real estate and human capital, as the present value of all future salaries, are key components of the consumption/wealth ratio in Spain. Specifically, we find that the cointegrating residuals of consumption, asset holdings, real estate holdings, and our measure of human capital provide a better forecast of future returns than does the standard proxy of the consumption/wealth ratio. This result is important because it clarifies the importance of country-specific components of wealth for cases in which the consumption/wealth ratio is employed as an instrument in conditional asset pricing models.Belén Nieto: Financial support from the Ministerio de Ciencia y Tecnología grant SEJ2005-09372 is gratefully acknowledged.Rosa Rodríguez: Financial support from the Ministerio de Ciencia y Tecnología grant SEC2003-06457 is gratefully acknowledged.     

Breaking the law when others do: A model of law enforcement with neighborhood externalities

A standard assumption in the economics of law enforcement is that the probability of a violator being punished depends only on the resources devoted to enforcement. However, it is often true that the productivity of enforcement resources decreases with the number of violators. In this paper, an individual who violates the law provides a positive externality for other offenders because the probability of being punished decreases with the number of individuals violating the law. This externality explains the existence of correlation between individuals’ decisions to break a law. The model evaluates the implications when determining the socially optimal enforcement expenditure, focusing specifically on the case of neighborhood crime. In particular, using a parametrized functional form, I show that neighborhood externalities will enhance or impede enforcement, depending on the crime rate.     

The logical status of risk – to burnish or to dull

Presented here is an elaboration of the fundamental features of the meaning of risk. It distinguishes between analytic approaches grounded in realism and postmodern (including constructionist) epistemologies and the presuppositions of each. It argues that attempts to fuse the ontology of risk with epistemological considerations into a common definition is both internally contradictory and a weak foundation for a theoretically justified definition of risk. In place of a fused definition of risk, it re‐affirms a definition risk as a state of the world, independent of percipient actors.     

How Campanian Small and Medium Enterprises (SMEs) Can Compete in the Global Agro-Food Industry

Importance of the agro-food industry in Italy and in Campania led us to investigate industry structure and small and medium enterprises' (SMEs) strategies for competing in the global scenario. We first analyzed the relevance of the Campanian agro-food system. Then we presented the results of face-to-face interviews to some SMEs. Through the interviews, we highlighted the SME value chain structures and their strategies to face global challenges. Most of the Campanian SMEs internationalize their activity by exporting their products abroad. Firms export in markets oriented to a high level of product quality—the main factor of Campanian agro-food SMEs' competitive advantage.     

Objective quality and business performance in service environments: moderating effects of entrepreneurs' knowledge and involvement

This study considers two main research issues: the relationship between objective quality and business performance and the moderating role of an entrepreneur's knowledge (education and experience) and involvement (exclusiveness in professional dedication) in that relationship. A sample of 103 rural tourism entrepreneurs in Spain serves as the study setting. Results indicate the positive influence of an establishment's quality on performance. Moreover, both knowledge and involvement have direct effects on performance, but involvement influences performance to a greater extent and even reaches profits. Positive moderating effects of experience and exclusiveness also emerge, as does an unexpected negative moderating effect of education.     

The Use of Metaphor in the Exploration of the Brand Concept

The use of metaphor in research and in marketing is discussed. A typology is presented for the structure of the use of metaphor in understanding the brand concept. Three underpinning or ‘root’ metaphors are identified together with fourteen associated branch or submetaphors. The three root metaphors are: brand as diferentiating mark, brand as person and brand as asset. A number of issues surrounding the use of metaphor in the literature on branding are identified. These include the mixing of metaphors and attempts to treat metaphors as if they are terms or constructs capable of separate definition, instead of devices by which we can understand more about the brand concept. Certain metaphors, such as brand loyalty, have become terms and have then taken on a separate meaning from the original entity they were meant to illuminate. An emergent root metaphor, brand as role, is identified as having potential to develop a broader understanding of the brand concept.

A life stage model is derived to explain how the role and use of individual metaphors evolves or changes over their life. Metaphors may pass through as many as four life stages: creation, when the metaphor is first used; a second stage in which the metaphor may become dormant; a life stage when the metaphor is at its most active; and a death stage when the metaphor becomes a term.     

The importance of the Logistics Performance Index in international trade

Logistics and transport increasingly play a pivotal role in international trade relations. The Logistics Performance Index (LPI) analyses differences between countries in terms of customs procedures, logistics costs and the quality of the infrastructure for overland and maritime transport. The aim of this article is to analyse the impact that each of these components has on trade in emerging economies using a gravity model. Furthermore, the study also attempts to detect possible advances in logistics in developing countries, which are grouped into five regions (Africa, South America, Far East, Middle East and Eastern Europe) by comparing the first LPI data published in 2007 with the most recent data, released in 2012. The results obtained reveal that improvements in any of the components of the LPI can lead to significant growth in a country’s trade flows. Specifically, LPI components are becoming increasingly important for international trade in many countries in Africa, South America and Eastern Europe.