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Environmental and Resource Economics - The purpose of this essay is to bring attention to some serious problems that exist in econometric application of fisheries economic models. These problems in...  相似文献   
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刘艳 《新理财》2006,(9):42-43
研究表明,乐观的领导者能够激励他们的公司赢得成功的机会。RossMaynard在这里阐述了如何养成积极乐观的习惯。[编者按]  相似文献   
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Objective: To evaluate the cost-effectiveness of exenatide twice daily (BID) vs bolus insulin lispro three times daily (TID) as add-on therapy when glycemic control is sub-optimal with titrated basal insulin glargine and metformin.

Methods: The analysis was based on the recent 4B Study, which compared exenatide BID and lispro TID as add-on therapies in subjects with type 2 diabetes insufficiently controlled, despite titrated insulin glargine. The Cardiff Diabetes Model was used to simulate patient costs and health benefits beyond the 4B Study. The Swedish healthcare perspective was adopted for this analysis; costs are reported in €EUR to aid interpretation. The main outcome measure was the cost per quality-adjusted life-year (QALY) gained with exenatide BID compared to lispro TID.

Results: Exenatide BID was associated with an incremental cost of €1,270 and a QALY increase of +0.64 compared with lispro TID over 40 years. The cost per QALY gained with exenatide BID compared with lispro TID was €1,971, which is within conventional limits of cost-effectiveness. Cost-effectiveness results were generally robust to alternative assumptions and values for key model parameters.

Limitations: Extrapolation of trial data over the longer term can be influenced by modeling and parameter uncertainty. Cost-effectiveness results were generally insensitive to alternative values of key model input parameters and across scenarios.

Conclusions: The addition of exenatide BID rather than insulin lispro to basal insulin is associated with similar or better clinical outcomes. Illustrated from the Swedish healthcare perspective, analysis with the Cardiff Diabetes Model demonstrated that exenatide BID represents a cost-effective treatment alternative to lispro TID as add-on therapy in type 2 diabetes patients insufficiently controlled on basal insulin.  相似文献   

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It is well known that a nonlinear recursive equation can produce a chaotic sequence at certain values of the parameter. Furthermore, in the chaotic regime, extremely small changes in the initial value or in the value of the parameter produce very large changes in the sequence. It is surprising therefore that a short segment of a chaotic sequence can be used to reconstruct large portions of the sequence and to forecast future values of the sequence over short ranges. Furthermore, while the accuracy of the forecasts is dependent on the precision of the data, the relationship is much less sensitive than might have been expected. This is demonstrated by fitting a two-parameter model to two different types of chaotic equations: one a polynomial and the other a trigonometric function. This leads to the expectation that under certain circumstances, it may be possible to forecast values in a chaotic series over limited ranges, even if initial data are somewhat degraded.  相似文献   
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