Changing the Institutional Framework of Statutory Audit: Internal Stakeholders' Perceptions of the Associated Benefit and Costs

This paper analyses the expected benefits and costs associated with changes to the institutional framework of statutory audits. We focus on five changes: Mandatory external audit firm rotation, auditor appointment by an independent regulator, a general ban on providing non-audit services, a ban on providing non-audit services to audit clients, and mandatory joint audits. We survey supervisory board members and management representatives from German companies to analyse how these changes affect the following beneficial attributes: Client-specific expertise and knowledge, general professional competence and expertise, independence and professional scepticism, and reputation. Our results show that none of the proposed changes is expected to increase the benefit of audits. A ban on non-audit services to audit clients is perceived to have the least disadvantageous effect, followed by a general ban on non-audit services, mandatory external audit firm rotation, appointment by an independent regulator, and mandatory joint audits. Although all changes are expected to increase auditor independence and professional scepticism, this increase is offset by a decrease in other beneficial attributes, particularly client-specific expertise and knowledge. Compared to supervisory board members, management representatives anticipate significantly larger decreases in the benefit of audits and significantly larger increases in costs.     

Determinants of corporate hedging: A (statistical) meta-analysis

While literature provides several hedging theories, evidence on the corporate incentives to hedge remains ambiguous. We synthesize data of empirical studies via statistical meta-analysis to test different hedging hypotheses. To our knowledge, this constitutes the first application of such a methodology in financial economics. Our results imply that financial distress costs induce firms to hedge. We find weak evidence that the underinvestment problem and the dependence on costly external financing influence hedging behavior. Taxes and agency conflicts do not show explanatory power. Because statistical and narrative reviews yield different outcomes, we see various other application possibilities for meta-analysis in financial economics.     

Continuous prophylaxis with recombinant factor IX Fc fusion protein and conventional recombinant factor IX products: comparisons of efficacy and weekly factor consumption

Background: Continuous prophylaxis for patients with hemophilia B requires frequent injections that are burdensome and that may lead to suboptimal adherence and outcomes. Hence, therapies requiring less-frequent injections are needed. In the absence of head-to-head comparisons, this study compared the first extended-half-life-recombinant factor IX (rFIX) product—recombinant factor IX Fc fusion protein (rFIXFc)—with conventional rFIX products based on annualized bleed rates (ABRs) and factor consumption reported in studies of continuous prophylaxis.

Methods: This study compared ABRs and weekly factor consumption rates in clinical studies of continuous prophylaxis treatment with rFIXFc and conventional rFIX products (identified by systematic literature review) in previously-treated adolescents and adults with moderate-to-severe hemophilia B. Meta-analysis was used to pool ABRs reported for conventional rFIX products for comparison. Comparisons of weekly factor consumption were based on the mean, reported or estimated from the mean dose per injection.

Results: Five conventional rFIX studies (injections 1 to >3 times/week) met the criteria for comparison with once-weekly rFIXFc reported by the B-LONG study. The pooled mean ABR for conventional rFIX was slightly higher than but comparable to rFIXFc (difference=0.71; p?=?0.210). Weekly factor consumption was significantly lower with rFIXFc than in conventional rFIX studies (difference in means?=?42.8–74.5?IU/kg/week [93–161%], p?Conclusion: Comparisons of clinical study results suggest weekly injections with rFIXFc result in similar bleeding rates and significantly lower weekly factor consumption compared with more-frequently-injected conventional rFIX products. The real-world effectiveness of rFIXFc may be higher based on results from a model of the impact of simulated differences in adherence.     

Estimating the economic costs of organized crime by synthetic control methods

The economic costs of organized crime have been estimated for the case of southern Italy by Pinotti (Economic Journal 2015; 125, F203–F232, 2015): using synthetic control methods, he finds that, due to the advent of the Italian Mafia in the regions Apulia and Basilicata, GDP per capita dropped by 16%. Replicating this study in a narrow sense by estimating the same model with the same data, but using different software implementations, we observe minor differences stemming from the different implementations. By identifying the correct implementation, we find that the loss in GDP per capita due to the presence of the Mafia has been slightly overestimated.