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781.
Heather J. McElroy Stuart K. Roberts Alex J. Thompson Peter W. Angus Sarah Jane McKenna Emma Warren 《Journal of medical economics》2017,20(1):72-81
Objective: To evaluate medical resource utilization (MRU) and associated costs among Australian patients with genotype 1 chronic hepatitis C (GT1 CHC), including both untreated patients and those receiving treatment with first-generation protease inhibitor-based regimens (telaprevir, boceprevir with pegylated interferon and ribavirin).Methods: Medical records were reviewed for a stratified random sample of GT1 CHC patients first attending two liver clinics between 2011–2013 (principal population; PP), supplemented by all GT1 CHC patients attending one transplant clinic in the same period (transplant population; TP). CHC-related MRU and associated costs are reported for the PP by treatment status (treated/not treated) stratified by baseline fibrosis grade; and for the TP for the pre-transplant, year of transplant and post-transplant periods.Results: A total 1636 patients were screened and 590 patients (36.1%) were included. Comprehensive MRU data were collected for 276 PP patients (F0–1 n?=?59, F2 n?=?58, F3 n?=?53, F4 n?=?106; mean follow-up?=?17.3 months). Thirty-eight (13.8%) were treatment-experienced prior to enrolment; 55 (19.9%) received triple therapy during the study. Data were collected for 112 TP patients (mean follow-up?=?29.9 months), 33 (29.5%) received a transplant during the study, and 51 (45.5%) beforehand. The annual direct medical costs, excluding drug costs, were higher among treated PP vs untreated PP (AU$: $1,954 vs $1,202); and year of transplant TP vs pre-/post-transplant TP (AU$: pre-transplant $32,407, transplant $155,138, post-transplant $7,358).Limitations: To aid interpretation of results, note that only patients with GT1 CHC who are actively managed are included, and MRU data were collected specifically from liver outpatient clinics. That said, movement of patients between hospitals is rare, and any uncaptured MRU is expected to be minimal.Conclusions: CHC-related MRU increases substantially with disease severity. These real-world MRU data for GT1 CHC will be valuable in assessing the impact of new hepatitis C treatments. 相似文献
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A linear programming algorithm is presented for determination of farm plans that are efficient under the mean-Gini criterion. Use of the algorithm is illustrated by applying it to a standard problem from the literature. The set of efficient plans is compared with those based on mean-variance and MOTAD analysis of the same problem. 相似文献
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This essay brings the art historical methodology of iconography to bear upon symbolic representations of futures issues. The discipline of iconography was developed as a way of analysing symbolism as it evolved from antiquity to the Baroque in order to identify and interpret the meaning of symbols within their wider cultural context. Symbols constitute significant indicators of the aspirations, belief systems and neuroses of the cultures which generate them. As such, they constitute fundamental tools in any analysis of past and contemporary attitudes towards science, technology and the future. With this in mind the essay considers symbolic images of the three fundamental aspects of futures studies—the interconnectedness of past, present and future, the plurality of options for the future, and the importance of the human input into technology and the creation of the future. 相似文献
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This article examines the contradictory and complex role played by Solidarity in the transformation of Poland since 1989. The organisational and ideological development of Solidarity is traced from 1980 through to 1994 in an attempt to explain an approach best described as ‘desperately seeking Polish capitalism’. 相似文献
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