Healthcare costs of urinary tract infections and genital mycotic infections among patients with type 2 diabetes mellitus initiated on canagliflozin: a retrospective cohort study

Objective: To assess the economic impact of urinary tract infections (UTIs) and genital mycotic infections (GMIs) among patients with type 2 diabetes mellitus (T2DM) initiated on canagliflozin.

Methods: Administrative claims data from April 2013 through June 2014 MarketScan^® databases were extracted. Adults with ≥1 claim for canagliflozin, T2DM diagnosis, and ≥90 days enrollment before and after canagliflozin initiation were propensity score matched to controls with T2DM initiated on other anti-hyperglycemic agents (AHAs). UTI and GMI healthcare costs were evaluated 90-days post-index and reported as cohort means.

Results: Rates of UTI claims 90 days post-index were similar in patients receiving canagliflozin for T2DM (n?=?31,257) and matched controls (2.7% vs 2.8%, p?=?.677). More canagliflozin than control patients had GMI claims (1.2% vs 0.6%, p?p?p?=?.150). GMI treatment costs were higher for the canagliflozin cohort ($3.68 vs $2.44, p?=?.041). Combined costs to treat either UTI and/or GMI averaged $31.29 per patient for the canagliflozin cohort v $39.77 for controls (p?=?.211). Rates and costs of UTIs and GMIs were higher for females than males, but the canagliflozin vs control trends observed for the overall sample were similar for both sexes. There were no significant cost differences between the canagliflozin and control cohorts among patients aged 18–64. Among patients aged 65 and above, GMI treatment costs were not significantly different, but costs to treat UTIs and either UTI and/or GMI were significantly lower for canagliflozin patients vs controls.

Conclusions: In a real-world setting, the costs to payers of treating UTIs and GMIs are generally similar for patients with T2DM initiated on canagliflozin vs other AHAs.     

Steady state properties of multi‐state economic models

A simple method to derive optimal steady states of multi‐state dynamic economic systems with minimal assumptions on the underlying processes is developed. This is accomplished by an n‐dimensional function defined over the n‐dimensional state space in terms of the model's primitives. The location and stability properties of optimal steady state candidates are characterized by the roots and derivatives of this function. A resource management example illustrates the simplicity and applicability of the method.     

R&D policies for desalination technologies

In many arid and semi‐arid regions whether or not to desalinate seawater has long been a non‐issue and policy debates are focused on the timing and extent of the desalination activities. We analyze how water scarcity and demand structure, on the one hand, and cost reduction via R&D programs, on the other hand, affect the desirable development of desalination technologies and the time profiles of fresh and desalinated water supplies. We show that the optimal R&D policy is of a non‐standard most rapid approach path (NSMRAP) type, under which the state of desalination technology — the accumulated learning from R&D efforts — should approach a pre‐specified target process as rapidly as possible and proceed along it thereafter. The NSMRAP property enables a complete characterization of the optimal water policy. The renewable nature of the fresh water stock permits a non‐monotonic behavior of the optimal stock process: under certain conditions, the stock is depleted, to be fully or partly) refilled at a later date.     

Monetary policy,exchange rate targeting and fear of floating in emerging market economies

This paper investigates whether central banks in emerging markets systematically respond to exchange rate movements. It estimates a structural general equilibrium model of a small open economy with an exchange rate-augmented Taylor-type rule for four countries. The results show that over the entire sample-period, South Africa and Mexico do not target the exchange rate, whereas Indonesia and Thailand do. In the 1980s and 1990s, all four countries targeted the exchange rate but in the aftermath of the Asian financial crisis, the Mexican peso crisis, and the end of apartheid, they all liberalized their exchange rate regimes, shifting toward inflation targeting.     

Estimation of Non-Stationary Social Accounting Matrix Coefficients with Supply-Side Information

Given aggregated data, a framework for estimating the entries of a social accounting matrix (SAM), or any large matrix of expenditures, trade or income flows, is developed. Under this framework it is possible to evaluate the contribution of structural and supply-side information, as well as policy variables, within the generalized context of a non-stationary SAM. Inference and diagnostic properties are developed as well. This new estimator can be viewed as a generalized maximum likelihood estimator. Stationary and non-stationary estimates of the US SAM for the years 1987-1994 together with the effects of supply-side variables are analyzed.     

Social Circumstances and Rationality:

Abstract Upon the uniformity in individuals’ decision‐making mechanism rests a great deal of the legitimacy of natural liberty. As we are all equally sovereign (cognitive‐wise), we only strike deals that inevitably make us better off. We all gain from trade and thus, as everyone is better off, so must be the whole of society. But could it be that people are rational yet not equally sovereign? In this paper, we examine Smith's interpretation of rationality, and we find that it is fundamentally a social concept. As such, the manifestation of rationality in individual behavior depends on how sophisticated is individuals’ access to public opinion. Consequently, individuals who are equally self‐interested may face very different sets of options, which are determined by their social circumstances. This difference may suggest that, although all agents may be motivated by the same objective, they cannot be considered as equally sovereign.     

Organizational politics and human resource management: A typology and the Israeli experience

This paper provides a critical examination of the meaning of organizational politics (OP) for human resource management (HRM). We develop our discussion in three main sections. First, we explain the commonly negative image of OP and argue that it also has some positive dimensions useful for understanding HRM. Based on this rationale and on previous writings we present a balanced and non-judgmental approach towards politics in HRM. We extend the discussion to suggest a specific typology and model that, in our view, better explains the meaning of OP for HRM than current definitions. The model includes aspects of positive/constructive HRM, negative/destructive HRM, ineffective HRM and virtual HRM. Finally, we examine the implications of the model in the context of the changing Israeli cultural environment. This historical–cultural analysis pertains to similar global shifts and points to future HRM challenges in Israel and around the world.     

Empirical analysis of motives underlying individual contributions to charity

Conclusion The direct benefits motive underlying charitable contributions has been extensively used as the dominant assumption in charity literature. Indded, it is theoretically simpler to assume independent rather than interdependent utility functions. This study does not justify exclusive assumption of direct benefits motive in theoretical or empirical analysis. Both indirect benefits and Kantian motives are implied by this study. While a clear cut dominance of one motive is not indicated in these results (and not surprising due to the cross-section, aggregate state data used), there is little or no support for the direct benefits motive. The existence of indirect and Kantian motives are indicated by the data.Future research into charitable behavior should take note of these findings, either to develop methodologies able to unambiguously discuss the motives, or to incorporate and provide more than simple acknowledgement of indirect benefits and Kantian motives.