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521.
The approach to the life-cycle theory has been used as an analytical tool of the firms' growth. Several researchers argue that organisations move across several development stages where different problems are found resulting from different management styles and priorities, and resources. This research aims to develop an empirical taxonomy of small medium enterprise (SME) growth in the service sector based on life-cycle and resource-based theories. The data were submitted to bivariate and multivariate analyses to develop and test an empirical life-cycle model. It was possible to conclude that the firms could be clustered in three life-cycle stages. Some implications and future researches are addressed.  相似文献   
522.
Inspired by Frederic (“Fred”) S. Lee’s theoretical contribution to institutional-heterodox economics, I make the case that the neoclassical price mechanism is not only flawed, but also irrelevant for the study of actual coordination mechanisms, hence the price mechanism — as a theory as well as a way of thinking — should be discarded. While this position was addressed by early institutionalists, starting with Thorstein Veblen, later institutionalists have not completely rejected the price mechanism. The sympathy for the price mechanism has prevented institutionalists (and other heterodox economists) from fully developing an alternative theoretical framework concerning how actual economic activities are organized. I, therefore, provide an institutionalist-heterodox framework of the provisioning process focusing on business enterprise activities. This framework shows how institutional economics becomes more refined and useful when it is married to other traditions in heterodox economics, in particular, Marxian, social, and post-Keynesian economics. Such an integrative approach is what Fred Lee showed through his work toward producing a better theory and policy for the underlying population.  相似文献   
523.
We assess the sustainability of public finances in OECD countries using unit root and cointegration analysis, controlling for endogenous breaks. Results deem fiscal sustainability as rather elusive since we find lack of cointegration – absence of sustainability – between government revenues and expenditures (except for Austria, Canada, France, Germany, Japan, Netherlands, Sweden and UK); improvements of the primary balance after worsening debt ratios only for Australia, Belgium, Germany, Ireland, Netherlands and the UK; and Granger causality from government debt to primary balances for 12 countries (suggesting Ricardian regimes).  相似文献   
524.
525.
This paper investigates whether minorities in academe exercise bargaining power in a way that influences hiring of other minority faculty. We develop a stylized model that shows how minorities influence the hiring of other minorities, taking into account the hiring of majority faculty. We postulate that such behavior is similar to the behavior of insider workers in the context of the insider-outsider literature.  相似文献   
526.
This paper represents global value chains (GVCs) as weighted networks of foreign value added in exports, which allows for the identification of the specific roles of countries and for the quantification of their relative importance over time. A major structural change occurred in the beginning of the century as GVCs steadily turned into global networks, amid an unprecedented growth of value-added flows and the rise of China as a major player. First-order network metrics highlight the vital but also distinct roles of Germany, the US, China and Japan in the international organisation of production. Germany is very relevant both as a user and as a supplier of foreign inputs, whilst the US acts mostly as a supplier of value added to other countries. Second-order properties of networks shed light on the complex architecture of GVCs, notably in terms of cyclical triangular relationships. Germany’s GVCs mostly root in direct relationships, whilst Japanese ones typically involve more than two countries.  相似文献   
527.
This article describes a socio-technical approach to public strategic planning. A multi-methodological framework with decision support systems (DSS) of problem structuring, multi-criteria decision analysis and strategic thinking was used in a decision conferencing process to support the key-players of the Pernambuco State Department of Social Development and Human Rights, in Brazil, to elaborate its 2008–2011 Multi-Annual Plan (PPA). This interactive process took place in June 2007, with thirty technical and political actors meeting in 5 consecutive days to discuss what should be the fundamental objectives/development axes of the PPA and to generate, assess and classify intervention programmes to achieve the objectives. Structuring objectives and programmes started by a group causal mapping session supported by the Decision Explorer DSS. Then, a multi-criteria group value model, created on-the-spot by means of the M-MACBETH DSS, helped the politicians in evaluating the overall benefit of each programme. The doability of the programmes was also appraised with MACBETH and, finally, the programmes were classified into four benefit versus doability categories defined in a $2\times 2$ strategic graph: “pearls” (programmes with high benefit value and easy to implement), “oysters” (high benefit but difficult to implement), “bread and butter” (easy to implement but of low added value) and “white elephants” (low benefit and difficult to implement). The group agreed that at least all pearls and oysters should be selected. The programmes were prioritised based on their value-for-effort and the robustness of the selection was analysed with the PROBE DSS a posteriori.  相似文献   
528.
Abstract

Aims: To evaluate the cost differences between a treatment strategy including tofacitinib (TOFA) vs treatment strategies including adalimumab (ADA), golimumab (GOL), infliximab (IFX), and vedolizumab (VEDO) among all patients with moderate-to-severe ulcerative colitis (UC) (further stratified by patients naïve/exposed to tumor necrosis factor inhibitors [TNFis]).

Materials and methods: An Excel-based decision-analytic model was developed to evaluate costs from the perspective of a third-party US payer over 2 years. Efficacy and safety parameters were taken from prescribing information and published trials. All patients started induction therapy on the first treatment in the strategy and continued if efficacy criteria were met and no major adverse event occurred (in which cases they proceeded to the next treatment in the strategy).

Results: The cost per member per month (PMPM) of the TOFA–>IFX–>VEDO–>GOL strategy ($1.11) was lower than that of the ADA–>IFX–>VEDO–>GOL strategy ($1.34; Δ = $?0.23) among the TNFi-naïve population (n?=?204 patients out of a plan of one million members). Similarly, the use of TOFA before ADA (i.e. TOFA–>ADA–>IFX–> VEDO) was also associated with lower PMPM costs than the use of ADA before TOFA (i.e. ADA–>TOFA–>IFX–>VEDO): $1.15 vs $1.25 (Δ = $?0.10). Similar, and often larger, differences were observed in both the overall moderate-to-severe population and the TNFi-exposed population. Sensitivity analyses resulted in the same conclusions.

Limitations: Our model relied on efficacy data from prescribing information and published trials, which were not head-to-head and slightly differed with respect to methods. Additionally, our model used representative minor and major ADRs (and the associated costs) to represent toxicity management, which was a simplifying assumption.

Conclusions: This analysis, the first of its kind to evaluate TOFA vis-à-vis other advanced therapies in the US, suggests the early use of TOFA among both TNFi-naïve and TNFi-failure patients results in lower PMPM costs compared with other treatment alternatives.  相似文献   
529.
530.
Economic complexity can be defined as the level of interdependence between the component parts of an economy. In input–output systems interindustry connectedness is a crucial feature of analysis, and there are many different methods of measuring it. Most of the measures however, have important drawbacks to be used as a good indicator of economic complexity, because they were not explicitly made with this purpose in mind. In this paper, we present, discuss and compare empirically different indexes of economic complexity as intersectoral connectedness, using the inter-industry tables of nine OECD countries. According to most of the measures of connectedness large economies (USA, Japan) tend to be more complex than small economies (for example, Denmark). But if another type of measures is considered, the opposite conclusion is drawn, signalling a hidden characteristic of interdependence that so far has not been detected by conventional measures. This result should qualify the widespread idea that more interconnected productive structures propagate more intensely exogenous shocks and/or economic policy measures.  相似文献   
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