MORGAN高速线材精轧机润滑系统污染控制

Moran现代高速线材生产线精轧机润滑系统污染控制,防止污染物侵入的有效措施和管理手段。精轧机润滑油过滤现状、存在的问题及解决办法。新型滤材制成的滤芯,适应精轧机润滑系统净化的机理与应用实践。     

吴岭水库土坝渗流及坝坡稳定性分析

本文对湖北省京山县吴岭水库土坝进行了有限元渗流计算和坝坡稳定性计算,在分析大坝基础部位的残坡积土、强风化砂岩的强透水性和下游排水体对于大坝渗流场的影响的基础上,得出渗流是引起下游坝坡不稳定的主要因素,为大坝的加固处理提供了理论依据,也可供同类土坝设计时参考。     

从三次浪潮看质量管理的发展

从农业经济、工业经济及知识经济的发展过程出发论述了质量管理的发展历程，并对知识经济环境下质量管理发展的特点及趋势进行了展望。     

水电工程竣工结算中遇到的问题

本文阐述了在办理138项单项工程竣工结算时的基本情况和遇到的问题。针对经常遇到的问题。提出了解决的方法。从而在工程投资控制中取得了预期效果，并指出内部审核可以进一步加强投资控制。     

我国沿海开放城市利用外资业绩与潜力比较研究

文章采用联合国贸发会议提出的“业绩指数”和“潜力指数”评估方法,对我国15个沿海开放城市利用外商直接投资业绩与潜力,分1995—1997年和2005～2007年两个时段进行定量分析。通过指数大小的排序,反映近年来这15个城市利用外资业绩与潜力的相对地位以及我国在这10多年的利用外资高峰期里,15个城市利用外资相对地位的变化,以期对各城市利用外资状况有一个客观的评价和把握,为各城市制定更有效地吸引及利用外资的政策措施提供决策依据。     

面向O2O的Web服务描述与建模

针对现有服务描述只考虑网上Web服务功能与质量属性,忽视用户网下服务需求的弊端.基于O2O环境中用户对网上服务和网下服务的综合需求,这篇文章对传统的Web服务描述进行了扩展,构建网上网下服务描述模型,设计了网上服务和网下服务的FQoS和QoS指标体系,定义了QoS属性的量化公式,建立了服务资源本体元模型,实现了对服务资源全面整体的描述,解决了网上服务和网下服务功能质量协同的问题.具有较强的理论意义和现实意义.     

股权分置改革的表决机制为何引发市场异常波动

本文应用事件研究方法和"有无"对比分析法的共同原理,对股权分置的事理进行分析,从而解释股权分置引发的个股股价上涨和大盘下跌的股票市场波动现象,并提出股权分置改革存在施舍机制和伤及无辜机制这两点机制设计不足,在此基础上提出了相应的对策建议.     

Cost-effectiveness analysis of utidelone plus capecitabine for metastatic breast cancer in China

Abstract

Objective: To estimate the cost-effectiveness of utidelone plus capecitabine therapy compared to capecitabine alone in patients with metastatic breast cancer (MBC) resistant to anthracyclines and taxanes treatment in the Chinese context and provide a reference for the marketing of utidelone in China.

Methods: A Markov model was developed based on the NCT02253459 clinical trial to simulate the clinical course of patients with metastatic breast cancer who had received taxanes and anthracycline therapy. The quality-adjusted life years (QALYs) and Incremental Cost Effectiveness Ratio (ICER) were then analyzed to evaluate the benefits. Two-parametric Weibull distribution was conducted to fit PFS and OS curves by using R. Sensitivity analyses were performed to evaluate the stability of the model designed.

Results: The addition of utidelone increased the cost and QALYs by $13,370.25 and 0.1961, respectively, resulting in an increased ICER of $68,180.78 per QALY. The most sensitive influential parameter on ICER was the price of utidelone. At the threshold of willingness-to-pay (WTP) of $24,380 (3 per capita GDP of China), the cost of utidelone per 30?mg of less than $18.5, $33.7, and greater than $48.8 resulted in a 100%, 50%, and 0% possibility of cost-effectiveness, respectively. The addition of utidelone was not cost-effective when it was $115.4 per 30?mg—the price of its analog paclitaxel. In consideration of varied economics levels across China, cost-effectiveness could be achieved with the price of utidelone ranging from $5.2 to $35.9.

Limitations: The survival curves extended beyond the follow-up time horizon, of which data were generated not from the real analyses but from our established two-parameter Weibull survival model.

Conclusion: It is recommended that the price of utidelone would be less than $18.5 per 30?mg in order to obtain cost-effectiveness for metastatic breast cancer patients resistant to anthracyclines and taxanes treatment in China.     

Analysis of Impacts of Climate Change and Human Activities on Hydrological Drought: a Case Study in the Wei River Basin,China

Climate change and human activity are the two major drivers that can alter hydrological cycle processes and influence the characteristics of hydrological drought in river basins. The present study selects the Wei River Basin (WRB) as a case study region in which to assess the impacts of climate change and human activity on hydrological drought based on the Standardized Runoff Index (SRI) on different time scales. The Generalized Additive Models in Location, Scale and Shape (GAMLSS) are used to construct a time-dependent SRI (SRI_var) considering the non-stationarity of runoff series under changing environmental conditions. The results indicate that the SRI_var is more robust and reliable than the traditional SRI. We also determine that different driving factors can influence the hydrological drought evolution on different time scales. On shorter time scales, the effects of human activity on hydrological drought are stronger than those of climate change; on longer time scales, climate change is considered to be the dominant factor. The results presented in this study are beneficial for providing a reference for hydrological drought analysis by considering non-stationarity as well as investigating how hydrological drought responds to climate change and human activity on various time scales, thereby providing scientific information for drought forecasting and water resources management over different time scales under non-stationary conditions.