Hiroshima and Nagasaki in Japanese guidebooks

This study investigates the presentations of Hiroshima and Nagasaki as postwar tourism destinations in a selection of Japanese-language guidebooks. Comparison is made between commonly voiced criticisms of Japanese attitudes toward the two atom-bombed sites and the tourism activities suggested by the publications themselves. An expected presentation emphasizing Japanese suffering as a result of the atom bombs is not found in the guides, but neither is an openness to discussion of the war. The conclusions reached find Hiroshima standing as emblematic of the rebuilding nation as a whole, while Nagasaki remains largely outside of the social and cultural dynamics of postwar Japan.     

分布式地矿点源信息系统的构件化体系结构设计

应用数据集市技术、分布式构件技术以及Java技术,本文提出了一种以Internet为运行平台的新的分布式地矿点源信息系统设计方案。文中从数据库体系结构和应用系统的体系结构方面,探讨其构件化体系结构设计的原理与方法。实践结果表明,这种新的设计方案可以使该系统的新一代产品以更低的代价发挥更大的效益。     

A note on the projection properties of Hadamard matrices obtained by the first Payley construction

We show that the projections on four factors of an arbitrary orthogonal array of strength 2 allow the estimation of main effects and two-factor interactions when all other effects are assumed to be zero, if those projections satisfy the bounds given by Weils theorem. The only exceptions are the Hadamard matrices of orders 16 and 24. A consequence is again the estimability of main effects and two-factor interactions for the projections on four factors of the first Payley construction for arbitrary run size.     

动物对温度适应的分子生物学研究进展

动物对环境温度的适应,会使自身的细胞内转录和表达模式发成变化,以适合环境的变化,此时它会出现新的基因开放和新蛋白因子的合成,这总的来说是动物对自身的一种保护方式。本文从基因水平、蛋白质水平、细胞膜水平等三个方面综述了动物对环境温度适应的研究概况,并讨论了动物对环境温度适应的分子生物学机制以及在进化中的意义。     

运动个体如何科学摄入蛋白质

蛋白质是组成人体结构成分和酶等特殊的功能性物质,并在生命过程中发挥着关键性作用。它是人体的主要成份之一,也是人体内部进行各种代谢活动的物质基础。蛋白质在机体内的存在形式和作用是多样化的,与运动个体的肌肉力量和肌肉蛋白合成紧密相关。在运动过程中,骨骼肌收缩活动会影响蛋白质和氨基酸代谢,这种运动的影响还延续到运动后。     

运用项目信息系统 提升建筑企业的竞争力

文章指出建筑企业应充分利用信息技术所带来的巨大生产力,不断创新,其中包括利用项目信息系统(PIS)从多方面对企业的业务流程与管理方法、手段等进行重组和改革,进而提升建筑企业的竞争力,更好地求得生存和发展。     

大豆蛋白非食品应用研究

大豆蛋白是大豆的主要农产品之一,主要在材料粘合剂、生物降解膜和塑料材料、纤维材料和生物医用材料等几个领域研究较多。随着目前全球性环境问题和石油资源的日益紧张,天然高分子材料的开发成为21世纪科学工作者研究的热点课题。文章就大豆蛋白在非食品方面的应用展开叙述,总结了大豆蛋白在胶粘剂、大豆蛋白膜、大豆蛋白塑料、大豆蛋白纤维和生物医用材料方面的应用。     

Economic modeling to evaluate the impact of chronic myeloid leukemia therapy management on the oncology care model in the US

Abstract

Objective: To develop an economic model to evaluate changes in healthcare costs driven by restricting usage of branded tyrosine kinase inhibitors (TKIs) through substitution with generic imatinib among chronic myeloid leukemia (CML) patients in a typical Oncology Care Model (OCM) practice, and examine the impact on Performance-Based Payment (PBP) eligibility.

Methods: An Excel-based economic model of an OCM practice with 1,000 cancer patients during a 6-month episode of care was developed. Cancer types and proportions of patients treated in the practice were estimated from an OCM report. All-cause healthcare costs were obtained from published literature. It was assumed that if a practice restricts usage of branded TKIs for newly-diagnosed CML patients, 80% of the market share of branded imatinib and 50% of the market shares of 2^nd-gen TKIs would shift to generic imatinib. Among established TKI-treated patients, it was assumed that 80% of the market share of branded imatinib and no patients treated with 2^nd-gen TKIs would shift to the generic.

Results: Four CML patients were estimated for a 1,000-cancer patient OCM practice with a total baseline healthcare cost of $51,345,812 during a 6-month episode. If the practice restricts usage of branded TKIs, the shift from 2^nd-gen TKIs to generic imatinib would reduce costs by $12,970, while shifting from branded to generic imatinib lowers costs by $25,250 during a 6-month episode. Minimum reductions of $3,013,832 in a one-sided risk model and $2,372,010 in a two-sided risk model are required for PBP eligibility; the shift from 2^nd-gen TKIs to generic imatinib would account for 0.4% and 0.5% of the savings required for a PBP, respectively.

Conclusions: This analysis indicates that the potential cost reduction associated with restricting branded TKI usage among CML patients in an OCM setting will represent only a small proportion of the cost reduction needed for PBP eligibility.     

TGF-β及其受体对胚胎着床的影响

TGF—β（transforming growth factor—β,TGF—β）是一类在结构上相对保守的生长因子,是细胞增殖、分化、细胞外基质合成和细胞凋亡的主要调节因子之一。近年来也发现,该家族成员的部分因子如TGF—β、骨形态形成蛋白（bone morphogeneticp rotein,BMP）／生长分化因子（growth and differentiation factor,GDF）、激活素／抑制素（Activin／Inhibin）也参与胚胎着床过程,且这些生长因子的表达表现出时空特异性。