1864例药物不良反应报告分析

目的了解某院药品不良反应(ADR)的发生特点及规律,为临床安全用药提供参考。方法对合肥市第二人民医院2016年至2018年上报的ADR报告进行回顾性分析。结果1864例ADR中,66~89岁患者所占比例最高(768例,占41.20%);女性患者984例,略多于男性(880例);静脉给药引发的ADR最多,占81.33%;发生ADR的药品主要为抗菌药品,其次为抗肿瘤药和中药制剂;ADR主要累及消化系统、皮肤及附件;ADR类型主要为一般ADR,导致严重的ADR主要是抗肿瘤药;ADR转归情况以痊愈和好转为主,两者占94.31%。结论老年患者更易发生ADR;抗菌药、抗肿瘤药等ADR发生率较高;所有剂型中注射剂型ADR发生率最高;消化系统、皮肤及附件损害最为常见。     

研发市场界定的适用困境及应对策略

研发市场是经营者在特定产品和技术竞争中形成的市场范围。由于研发活动的不确定性，反垄断执法机关在界定研发市场时难以准确厘定市场边界，更深层次的原因在于维持竞争与激励研发的关系尚不明晰。研发竞争中的垄断行为难以通过相关市场界定的方式判断其违法性，需要结合具体案情和市场条件，动态分析涉案行为是否损害产品或技术研发竞争。     

有效提升粮油检测数据的准确度

本文主要探讨粮油检测数据的科学性和准确性,包括粮油样品的扦取、检测误差的控制、检测质量体系的运行、检测数据处理的原则和检测报告的编制等。     

The effects of tourism on HSR: Spanish empirical evidence derived from a multi-criteria corridor selection methodology

The exorbitant cost of new High-Speed Rail (HSR) lines requires a selection methodology to define which HSR corridors within a network should be built first, and the most suitable evaluation tool appears to be the multi-criteria approach. In any corridor-ranking methodology, and especially in countries with high tourism attractiveness, tourism impacts on HSR should be considered as a variable.In addition to economic geography and destination choice models, the current literature on tourism demand is dominated by econometric models using a single-equation time-series based approach. However little research has been done so far on methodologies to rank HSR corridors taking into account the tourism variable. In 2014, a ranking methodology developed by Todorovich and Hagler was validated using the current Spanish HSR network. Twelve variables were used to create an index to assign scores to the city pairs, but tourism was not included as a variable. The findings showed the consistency of the model for ranking pairs mainly in the top O–D relations; however the tool failed to discriminate clearly between secondary groups of corridors.The aim of this paper is to assess empirically the positive effect of tourism on HSR and to enhance the abovementioned ranking tool with a tourism database. The new methodology is tested by application to 1176 city pairs in Spain, and the results clearly show that the implementation of a tourism variable helps discriminate between secondary groups of corridors and offers a more effective approach for determining the implications of tourism on HSR.     

Configurations of business strategy and marketing channels for e-commerce and traditional retail formats: A Qualitative Comparison Analysis (QCA) in sporting goods retailing

This article applies a configurational approach to study the fit between retail format, business strategy, and multi-channel setup. Its empirical material consists of five case studies, and a data set of 74 sporting goods retailers in Sweden. Our results show that a retailer can create strategic advantages when its multi-channel setup fits with its business strategy, and that retail format is important for explaining differences in growth and profit, the former being assigned to e-commerce and the latter to physical stores. Moreover, the study reveals that to some extent online channels also have positive performance implications for physical store retailers.     

Impact of customers' assessment of website attributes on e-relationship in the securities brokerage industry: A multichannel perspective

The paper focuses on the comparison between pure e-retailers and multichannel retailers' customers and how they differ in their evaluations of functional and relational attributes of the website, as well as how these attributes impact online relationships. An online survey among online securities investors was conducted. Subjects were self-selected from blogs and forums dedicated to personal finance. A total of 326 questionnaires formed the final sample of this study. By using a series of univariate analyses of variance, structural equation modeling, and multi-group analysis, this research empirically demonstrates that the e-service quality evaluation and determinants of online relationship are different in multichannel contexts versus pure online ones. Results show that customers of multichannel retailers are not more loyal than those of pure online retailers. However, multichannel retailers exceed pure online retailers at achieving a higher level of online trust and a higher assessment of website features. The paper concludes with managerial implications that may be useful in multichannel retailing.     

An estimation of returns to scale of airport airsides under multiple optimal solutions in DEA

The returns to scale (RTS) nature of 37 Chinese airport airsides are investigated in this paper. Multiple optimal solutions in DEA (Data Envelopment Analysis) models may lead to error RTS estimation. To address this problem, we use the (Zhu and Shen, 1995) RTS method. The empirical study shows that all those airsides with two runways operate under decreasing RTS and those airsides with only one runway either operate in the area of increasing RTS or in the area of constant RTS.     

Analysis of tourism information sources using a Mokken Scale perspective

This study contributes to the analysis of information sources as a determinant of the travel decision-making process. It focuses on the use of Mokken Scale Analysis (MSA) as a new methodological approach to detect unidimensional hierarchical scale in the analysis of information sources. The paper shows how MSA can be applied in the tourism field. Findings reveal two different scales (active and passive information search scales) for classifying information sources in tourism. Variations in the scales are revealed, taking socio-demographic and travel behavioural variables into consideration. The conclusions clearly explain the implications for tourism marketers and make recommendations for future research.     

'More is not necessarily better': the relationship between the quantity and quality of training efforts

International comparisons indicate that, on average, Belgian companies spend less on training than their French, German and Dutch counterparts. Encouraging companies to commit to training has consequently been an important policy goal over the last few years. One notable aspect of the policy to encourage training efforts by companies is that the effort is always represented in terms of the resources invested (input), not in terms of the learning achieved (output) or the quality of training programmes (throughput). Government policy is aimed at increasing the level of investment in company training. One of the questions we wish to investigate is whether this input-oriented approach to the training issue is actually effective. Whether companies will succeed in raising human capital to ever-increasing levels may depend not only (and maybe not even chiefly) on the extent of financial investment in training. The investment level does not necessarily determine the quality of the training processes developed by companies. Therefore, this paper focuses on the following research questions: (1) to what extent do companies monitor the systematic development of sufficiently effective training processes? In other words, is qualitative under-investment an issue, alongside financial under-investment? (2) Is the level of financial investment in company training correlated to the quality of training processes? The empirical data confirm that a kind of 'qualitative' under-investment can be reported and that the relationship between the level of investment in training and the quality of the training programmes is weak.     

Risk-based decision analysis in support of precautionary policies

A decision-analytic model for avoiding a risky activity is presented. The model considers the benefit and cost of avoiding the activity, the probability that the activity is unsafe, and scientific tests or studies that could be conducted to revise the probability that the activity is unsafe. For a single decision maker, thresholds are identified for his or her current subjective probability that the activity is unsafe. These thresholds indicate whether the preferred course of action is avoiding the activity without further study, engaging in the activity without further study, or conducting a test or research programme to obtain additional information and following the result. When these thresholds are low, precautionary action is more likely to be warranted. When there are multiple stakeholders, differences in their perceptions of the benefit and cost of avoidance and differences in their perceptions of the accuracy of the additional information provided by the test or research programme combine to create differences in their decision thresholds. Thus, the model allows for the rational expression of differences among parties in a way that highlights disagreements and possible paths to conflict resolution. The model is illustrated with an application to phytosanitary standards in international trade and examined in terms of recent empirical research on lay perceptions of risks, benefits, and trust. Further research is suggested to improve the elicitation of model components, as a way of fostering the legitimate application of risk-based decision analysis in precautionary policy making.