This study assesses the relative merits of alternative cultural frameworks as the basis to construct indices of cultural distance
using the one introduced by Kogut and Singh (1988). We assess not only Hofstede (1980, 1991) but also the more recent Schwartz
(1994, 2003) and GLOBE (2004) frameworks. Using primary data collected through a questionnaire survey of 228 foreign manufacturing
firms in the Republic of Korea, we find consistently across the three different frameworks that cultural distance has a positive
association with full ownership. These results support not only the robustness of Kogut and Singh’s method to construct an
index of cultural distance but also the consistency of the alternative indices of cultural distance used to explain ownership
mode decisions by MNEs.
Aims: This study assessed the cost-effectiveness of the subcutaneous RANKL inhibitor, denosumab, vs the intravenous bisphosphonate, zoledronic acid, for the prevention of skeletal-related events (SREs) in patients with prostate cancer, breast cancer, and other solid tumors (OST) in the Czech Republic.
Materials and methods: A lifetime Markov model was developed to compare the effects of denosumab and zoledronic acid on costs (including drug costs and administration, patient management, SREs, and adverse events), quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios from a national payer perspective. Different discount rates, time horizons, SRE rates, distributions, and nature (asymptomatic vs all SREs), and the inclusion of treatment discontinuation were considered in scenario analyses. The robustness of the model was tested using deterministic and probabilistic sensitivity analyses.
Results: Across tumor types, denosumab was associated with fewer SREs, improved QALYs, and higher total costs over a lifetime. The incremental cost per QALY gained for denosumab vs zoledronic acid was 382,673 CZK for prostate cancer, 408,450 CZK for breast cancer, and 608,133 CZK for OST. Incremental costs per SRE avoided for the same tumor type were 54,007 CZK, 51,765 CZK, and 94,426 CZK, respectively. In scenario analyses, the results remained similar to baseline, when different discount rates and time horizons were considered. At a non-official willingness-to-pay threshold of 1.2 million CZK, the probabilities of denosumab being cost-effective vs zoledronic acid were 0.64, 0.67, and 0.49 for prostate cancer, breast cancer, and OST, respectively.
Limitations: The SRE rates used were obtained from clinical trials; studies suggest rates may be higher in clinical practice. Additional evidence on real-world SRE rates could further improve the accuracy of the modeling.
Conclusions: Compared with zoledronic acid, denosumab provides a cost-effective treatment option for the prevention of SREs in patients with prostate cancer, breast cancer, and OST in the Czech Republic. 相似文献
This paper offers a new perspective regarding the effects on a host economy of the entry of multinational enterprises (MNEs). We use a computable general equilibrium (CGE) approach, through a version of the Global Trade Analysis Project (GTAP) model extended to incorporate MNEs. The analysis is applied to the Czech Republic, a country that has received substantial inflows of foreign direct investment in the last few years. A special attention has been paid to the issue of profit repatriation. We find that the negative effects of profit repatriation are sizeable, and might even offset the positive impact of the entry of MNEs. 相似文献
As Bangladesh celebrated its 37th anniversary of Independence and National Day on March 26, China's Foreign Trade interviewed H.E.Mr.Munshi Faiz Ahmad,Ambassador Extraordinary and Plenipotentiary of Bangladesh to the People's Republic of China."Bangladesh and China enjoy traditional friendship for a long time.For example,Xuan Zang (the Chinese Buddhist monk famous for his"Journey to the West"during the Tang dynasty) and Admiral Zheng He (the great Chinese navigator from the Ming dynasty) visited Bengal in their respective times. 相似文献
Land consolidation (LC) is a tool for improving the effectiveness of land cultivation and for supporting rural development. In the Czech Republic it is, in addition, used to remedy the damages and wrongs caused by 40 years of suppression of land ownership. This paper investigates the specific conditions and various outcomes of LC in three study areas, focusing on the evaluation criteria of land ownership and plot arrangement before and after LC. The three study areas contain contrasting observed features, and they therefore provide a good illustration of a whole range of factors that can affect the rate of LC. The author designed LC projects in each of the study areas between 1994 and 2003, and defined two sets of criteria for ex ante and ex post evaluation based on size, shape and juxtaposition of the plots, on the natural and social conditions, and on the economic benefits and advantages of LC for the landowners. The relationship between the ex ante criteria and the three LC indicators was analyzed using a multiple regression approach. The results show that the initial conditions had a strong effect on the outcomes of the LC programmes. Defining the criteria and the models for the Czech Republic will help to improve the methodological principles underlying LC projects, and it will also support the decision-making processes of the LC authorities in order to optimize the allocation of limited funds. 相似文献