绥中地籍登记信息平台构建

地籍登记信息平台的建立能够支持地籍登记工作实现信息实时更新和共享。系统基于C/S架构进行开发,以绥中县为例,建立农村宅基地数据库,集成多源地理空间数据,为用户提供宅基地信息的基本浏览和查询,实现数据的信息化管理,提高土地管理部门的工作效率和服务质量,对当前登记信息平台的建立进行了有益的探索。     

絮凝沉淀去除马铃薯淀粉加工废水中蛋白的试验研究

采用絮凝沉淀法去除马铃薯淀粉废水中的蛋白质。经过方案比选．最终选择聚丙烯酰胺作为絮凝剂,结果表明：在聚丙烯酰胺投加量为70mg／L,pH值为5,温度为20℃,反应时间40min的最佳工艺条件下。采用聚丙烯酰胺絮凝沉淀法对马铃薯淀粉加工废水中的COD、蛋白质、BOD、SS都有一定的去除效果。COD的去除率保持在30％～40％,蛋白质的去除率保持在45％～55％,BOD的去除率保持在10％-15％．SS的去除率保持在50％-60％,大大减轻了后续处理构筑物的负担。     

Cost-effectiveness of dipeptidyl peptidase-4 inhibitor monotherapy versus sulfonylurea monotherapy for people with type 2 diabetes and chronic kidney disease in Thailand

Objective: With a high prevalence of chronic kidney disease (CKD) in type 2 diabetes (T2DM) in Thailand, the appropriate treatment for the patients has become a major concern. This study aimed to evaluate long-term cost-effective of dipeptidyl peptidase-4 (DPP-4) inhibitor monothearpy vs sulfonylurea (SFU) monotherapy in people with T2DM and CKD.

Methods: A validated IMS CORE Diabetes Model was used to estimate the long-term costs and outcomes. The efficacy parameters were identified and synthesized using a systematic review and meta-analysis. Baseline characteristics and cost parameters were obtained from published studies and hospital databases in Thailand. Costs were expressed in 2014?US Dollars. Outcomes were presented as an incremental cost-effectiveness ratio (ICER). One-way and probabilistic sensitivity analyses were performed to estimate parameter uncertainty.

Results: From a societal perspective, treatment with DPP-4 inhibitors yielded more quality-adjusted life years (QALYs) (0.024) at a higher cost (>66,000 Thai baht (THB) or >1,829.27 USD) per person than SFU, resulting in the ICER of >2.7 million THB/QALY (>74,833.70 USD/QALY). The cost-effectiveness results were mainly driven by differences in HbA1c reduction, hypoglycemic events, and drug acquisition cost of DPP-4 inhibitors. At the ceiling ratio of 160,000 THB/QALY (4,434.59 USD/QALY), the probability that DPP-4 inhibitors are cost-effective compared to SFU was less than 10%.

Conclusions: Compared to SFU, DPP-4 inhibitor monotherapy is not a cost-effective treatment for people with T2DM and CKD in Thailand.     

动物对温度适应的分子生物学研究进展

动物对环境温度的适应,会使自身的细胞内转录和表达模式发成变化,以适合环境的变化,此时它会出现新的基因开放和新蛋白因子的合成,这总的来说是动物对自身的一种保护方式。本文从基因水平、蛋白质水平、细胞膜水平等三个方面综述了动物对环境温度适应的研究概况,并讨论了动物对环境温度适应的分子生物学机制以及在进化中的意义。     

Disease-specific cost savings of treating nighttime versus daytime gastroesophageal reflux disease in an employed population

Summary

Objective: The extent to which proton pump inhibitors (PPIs) can offset direct medical costs by reducing symptoms related to gastroesophageal reflux disease (GERD) in order to improve work productivity is not well understood. This study aimed to evaluate the economic impact of treating GERD with PPIs versus no treatment, from an employer's perspective.

Study design: An economic model was developed to simulate symptom reduction and breakthrough symptoms as well as associated costs over 1 year among a population of 100,000 with a 20% GERD prevalence rate. Medical costs, including GERD-related office visits, hospitalisations and procedures, were delineated by symptom severity. Indirect costs represented the monetised work productivity loss. PPI treatment costs $2/day (standard dose).

Results: The GERD burden was substantial ($62,500,000). Treatment yielded $32,600,000 in savings ($1,630 saved/patient/year), mostly from reducing indirect costs. Treatment produced greater savings among nighttime GERD patients throughout the PPI cost range ($1–$5/day). Savings dropped if the price of standard doses of PPI exceeded $3.92/day for the treatment of daytime GERD patients.     

Earthquake effects on tourism in central Italy

This paper proposes an approach to economic assessment of the impact on tourist flows of the earthquake that hit the Umbria region in Central Italy on September 26, 1997. Local arrivals in Assisi fell drastically the month following the main shock, compared to the same month of the previous year. The event study methodology, frequently applied in finance, is employed to evaluate the statistical relevance of the shock over time and space. A further and straightforward application of the event study analysis assesses the substantial amount of loss between October 1997 and June 1998 due to the drop of tourism business.     

Large-scale participatory co-shaping of technological developments: First experiments with PARDIZIPP

A future-oriented participatory procedure on the basis of the Delphi method was developed and empirically tested a first time with the goal to improve the shaping of technological developments. The technology under study here was micro-electronics or rather their relationship with labor and the test took place in NorthRhine-Westphalia.Today problems exist in all walks of life. There is a lot of talk about today's problems as if they were new, though one has heard similar arguments throughout history. How do we assess if we are really in danger of bringing the world to an end? Although this danger appears real, it would not be the first time in history that people have thought and felt like this--However, one thing that is new are the consequences of modern sciences and technology, which are not suited to given social and environmental requirements. They have given rise to questions concerning the quality of the decision-makers. The questioning of many of these decisions has increased for some time and is now getting more and more specific, with a demand for quality and information rather than managerial skills and competitiveness from the decision-makers. The term ‘decision-maker’ describes those who determine the application of technology, science and technical equipment which has either existed for a long time already or has recently been developed.--It is not easy to change the structures and processes of decision-making so that new structures and processes will be more suited to social and environmental requirements. We have tested our ideas as to how this could be done, in an empirical project. Although we called it ‘Project NRW-2000’, it would probably be better described as an experiment.--We persuaded 90 ordinary people to participate in this project as ‘experts on daily life and work’. This group was asked to work in six regional sub-groups and discuss, with reference to three given normative societal scenarios for the year 2020, the relationship between microelectronics and labour markets of the year 2020, on the basis of a participatory Delphi procedure. Before we elaborate on the concept of our project in Section 3, we would like to outline it in terms of the mainstream of the sociology of technology as well as with research on ‘acceptance’ in Section 1. In Section 2 we will briefly illustrate the framework of the research programme ‘Socially Oriented Shaping of Technology’ of the state of Northrhine-Westphalia, which funded our research project. Section 4 particularly deals with the participatory elements of our project, while Section 5 is devoted to the development of the scenarios. Section 6 sums up the results of the ‘scenario-construction’. Regarding specific elements, we restrict ourselves to topics concerning technology, labour, and the relationship between women workers/employees and technology. As a final outlook we deal with the political implications of our approach. All that is left is to remind our readers that we regard this project as a first application or experiment within our overall approach.     

溶剂萃取法提取蚕蛹油研究

本文通过实验得出溶剂萃取法提取蚕蛹油的最佳工艺条件为:采用石油醚∶丙酮(1∶1)(v/v)按固液比1∶3(w/v),在60℃下回流浸提2小时,提取率可达85.10%。     

“互联网+”生态旅游产品价值实现机制研究——以南山国家公园线路为例

在大力探索生态产品价值实现背景下,生态旅游作为公共产品,为推动生态产品价值实现和中国特色生态文明建设新模式的形成提供有力支撑。本研究选取南山国家公园线路为案例,以S-O-R理论为基础,构建生态旅游产品购买意愿模型,探究生态旅游产品在微信朋友圈购买意愿的内在机制。研究发现：（1）生态旅游产品在微信朋友圈的购买意愿存在“营销媒体特征—感知功利价值—购买意愿”和“社交媒体特征—感知享乐价值—购买意愿”两种形成机制;（2）生态旅游产品在微信朋友圈的购买意愿同时受到功利性因素和享乐性因素的影响,但功利性因素的影响占主导作用;（3）生态旅游产品的价格和产品图片的美观性对感知功利价值的影响较强;（4）微信朋友圈的社交存在感和微信好友的能力对感知享乐价值的影响较强;（5）不同人口学特征下,被调查者的购买意愿有显著差异。建议开展组合式营销、改善营销信息的内容和质量、保持高度的用户粘性、重视“专业形象”打造、针对主要客源市场“有的放矢”营销等实践,以促进南山国家公园生态旅游产品的价值实现。     

粮食游离氨基酸含量测定方法精密度及回收率分析

根据粮食中游离氨基酸的氨基与水合茚三酮反应生成蓝紫色化合物,采用比色法测定粮食中游离氨基酸含量。采用二因素随机区组试验设计和生物统计软件SSPSS11．5的单因素方差分析表明,本方法测定的粮食种类间游离氨基酸含量次序为大豆〉小麦=玉米〉糙米〉大米,其中大米游离氨基酸含量最低。该方法非常灵敏,加入标准亮氨酸2mg的回收率对谷物大于58．8％,对大豆大于20．2％,精密度小于20％。