The management of acid-related disorders: the burden of disease and the need for effective treatment

Summary

A large and increasing number of people suffer from acid-related disorders such as dyspepsia, gastro-oesophageal reflux disease (GORD), and peptic ulcer disease. In 1994 alone, about 2 million patients consulted their family doctor for an acid-related disorder. Treatment of these patients represents a high cost to the NHS in terms of medications, consultations, referrals and treatment of complications. UK government statistics also indicate that there is a huge economic burden associated with acid-related disorders in terms of lost productivity.

Effective management of acid-related disorders is required to ensure that the available resources are used efficiently and to the benefit of the NHS, society and the patient.

Proton pump inhibitors are the most effective and predictable therapy available for acid-related disorders and many clinical studies have demonstrated their superior efficacy over H2-receptor antagonists in the management of these conditions. These therapeutic advantages translate into economic gains. Several economic studies have shown that it is more cost-effective to treat GORD and peptic ulcer disease with the proton pump inhibitor omeprazole than with H2-receptor antagonists.     

20Kt/a煅烧焦回转窑耐高温下料溜管技术改造的研究

介绍在大港油田20Kt/a煅烧焦厂煅烧回转窑高温下料溜管的投产使用中,针对出现的焊口开裂、高温下管体变形等一系列问题,通过焊接应力分析、高温温差应力、溜管整体结构受力分析等方法和原理,从整体结构和焊接方法两方面进行技术改造,探讨出符合大港油田20Kt/a煅烧焦60米回转窑使用要求的耐高温下料溜管制作安装方法。     

多气源掺混作为城市燃气过渡气源在实际中的应用

为了解决青岛市煤气供需不平衡的矛盾,为引进天然气作好前期准备,我公司将多种气源(焦炉煤气、焦炉烟道气、空气、全水煤气、半水煤气、液化石油气、石化厂净化干气)均匀掺混,掺混后的煤气热值控制在15 675～17000 kJ/m3(适合青岛市燃具),含氧量不大于4.0%.通过实际应用,多气源掺混供气,满足了供气需要,可以作为过渡气源满足城市燃气转换成天然气的需要.     

我国热电联产的新发展

概述了我国热电联产的发展现状,集中分析了热电联产的发展趋势。以北京市为例,叙述了热电联产在改善环境方面的作用。指出发展热电联产应是今后实施"优化发展煤电"的重点方向,展示了热电联产与分布式能源市场的广大前景。     

Futures beyond dystopia

The speculative imagination is an higher-order human capacity that can productively explore the not-here and the not-yet. To some extent it is already doing so. But these explorations are limited by prevailing cultural assumptions. The purpose of this paper is to suggest that there are other arenas to explore that, were they taken seriously, could exert sufficient symbolic ‘pull' to qualify as desirable images of futures. They could then begin to act as ‘magnets' for the realisation of possibilities that are presently obscured.     

实施管杆分类管理 确保下井管杆质量

为更好地发挥管杆的使用价值,确保质量,延长检泵周期,中原油田采油一厂积极探索管杆管理的新思路,新办法。在借鉴国内油田先进管理经验的基础上,制定了管杆分年限、分类、分级使用管理的新办法。该管理办法是管杆管理的新模式,是有效解决管杆管理问题的新途径。     

离心泵检修之我见

作者对自己在离心泵的检修和维护方面的经验进行了归纳,特别是在离心泵常见故障方面,重点对排除故障的方法进行了论述。目的是能使同行在离心泵的检修方面有些参考及借鉴作用。     

Openprocess在热网监控系统中的应用

分析Openprocess在热网监控系统中的应用背景和客户需求,提出解决方案,并通过实验论证其可行性与有效性。     

Disease-specific cost savings of treating nighttime versus daytime gastroesophageal reflux disease in an employed population

Summary

Objective: The extent to which proton pump inhibitors (PPIs) can offset direct medical costs by reducing symptoms related to gastroesophageal reflux disease (GERD) in order to improve work productivity is not well understood. This study aimed to evaluate the economic impact of treating GERD with PPIs versus no treatment, from an employer's perspective.

Study design: An economic model was developed to simulate symptom reduction and breakthrough symptoms as well as associated costs over 1 year among a population of 100,000 with a 20% GERD prevalence rate. Medical costs, including GERD-related office visits, hospitalisations and procedures, were delineated by symptom severity. Indirect costs represented the monetised work productivity loss. PPI treatment costs $2/day (standard dose).

Results: The GERD burden was substantial ($62,500,000). Treatment yielded $32,600,000 in savings ($1,630 saved/patient/year), mostly from reducing indirect costs. Treatment produced greater savings among nighttime GERD patients throughout the PPI cost range ($1–$5/day). Savings dropped if the price of standard doses of PPI exceeded $3.92/day for the treatment of daytime GERD patients.     

浅谈煤矿热交换站循环泵的选型

热交换站中的循环泵是整个采暖系统的核心设备,动力之源,重要性如同一个人的心脏,它的选型正确与否,直接关乎整个采暖系统的运转。本文对作者接触到的几个新建、改建的煤矿热交换站在循环泵选型上存在的误区进行分析,指出解决问题的对策。