Adverse event-related costs for systemic metastatic breast cancer treatment among female Medicaid beneficiaries

Objective: This retrospective study compared the real-world incidence and costs of systemic treatment-related adverse events (AEs) in patients with metastatic breast cancer in a Medicaid population.

Methods: Insurance claims data for adult women who received biologic or chemotherapy (± hormonal therapy) for metastatic breast cancer between 2006–2013 were extracted from the Truven Health MarketScan^® Multi-State Medicaid database. Incidence of AEs (per 100 person years) and average monthly AE-related healthcare costs (per-patient-per-month) during each line of therapy (first or later lines) were estimated. The association between AEs and total all-cause healthcare costs was estimated using multivariable regression.

Results: A total of 729 metastatic breast cancer patients were analyzed. Hematological (202.3 per 100 person years) and constitutional AEs (289.6 per 100 person years) were the most common class of AEs reported. Unadjusted per-patient-per-month AE-related expenditure by class were highest for hematological AEs ($1524), followed by gastrointestinal ($839) and constitutional AEs ($795), with anemia ($942), nausea/vomiting ($699), and leukopenia/neutropenia ($550) having incurred the highest total AE-related costs. Adjusted total all-cause monthly costs increased with the number of AEs ($19,701 for >7 AEs, $16,264 for 4???6 AEs, and $13,731 for 1???3 AEs) compared to no AEs ($5908) (all p?Conclusions: Among metastatic breast cancer patients treated with systemic therapy in a Medicaid population, AEs were associated with significant increases in costs, which increased with the number of AEs experienced. Therapies associated with a lower incidence of AEs may reduce cost burden and improve patient outcomes.     

基于成本动因的工程成本控制体系的探讨

目前,多数施工企业采用的目标成本管理体系存在一定的局限性,本文试图利用作业成本法和挣得值法对目标成本管理体系进行改进,探讨基于成本动因的工程成本控制体系。     

油田操作成本经济界限模型研究

本文以操作成本经济界限为研究对象,运用技术经济学原理,结合某油田的实际情况,在设置众多可以赋值的参数的条件下,建立了操作成本经济界限模型,在此基础上,根据操作成本经济界限模型对其参数进行赋值,测算在不同井深、综合递减率、单井日产量下的操作成本经济界限。最后运用统计软件SPSS对测试数据进行分析,得到了操作成本经济界限与井深、综合递减率、单井日产量呈高度相关关系,并得到了以井深、综合递减率、单井日产量为自变量,操作成本经济界限为因变量的线性相关模型,对油田今后合理的分配操作成本提供了科学的依据。     

中国移动通信市场价格博弈影响因素分析及对策

价格竞争作为一种信号传递机制,体现了市场主体之间相互学习并调整各自行动,根据变化的条件和环境采取有效率的行为。本文基于中国移动通信市场价格博弈本质解析的基础上,分析了不对称管制、经济租金、转移成本和产品差异化等要素对中国移动通信市场价格博弈的影响机制,提出了增进中国移动通信市场有效竞争程度以及缓解行业价格博弈的若干对策建议。     

基于SLP方法的公司厂区布局研究

文章分析了YH公司厂区原布置方案的缺陷:(1)不能满足企业的发展要求;(2)未进行物流成本核算;(3)缺乏对企业形象的重视;(4)忽视厂区的绿化建设;(5)无专门的物料堆放区。然后,针对厂区原布置方案的缺陷,结合企业的发展目标,确定厂区布置目标。在厂区布置原则的基础上,根据各车间、仓库之间的物流量和相对距离,计算新、旧方案的物流成本,从而选择较优的方案。     

浅谈电气设备倒闸操作技术实践研究

结合工矿现场,就一些典型倒闸操作的技术要点进行分析,并指出操作过程中的关键环节及应注意的事项。     

项目管理与成本核算中隐性成本的探讨

本文从当今施工企业项目管理模式入手,重点从项目管理中的项目经理的管理机制和责任成本管理机制二个方面展开,对如何实现项目管理系统化、科学化进而推进施工企业的良性发展做详细阐述。     

银行监督降低了经理人代理成本吗?来自房地产上市公司的证据

论文以银行监督与经理人代理成本为主线,研究银行监督作为一种外部治理机制与内部治理机制、政府控制和债权人保护（法律环境）之间的关系如何影响经理人代理成本。研究表明：银行在房地产上市公司中不但没有发挥监督作用,反而提高了经理人代理成本,即银行负债的杠杆治理效应被严重扭曲,相反,非银行负债在房地产上市公司中发挥了应有的杠杆治理效应。因此,必须进一步深化银行与国有企业的产权改革,其重点是降低政府干预程度,发挥银行负债的硬约束功能：银行作为企业的大债权人应该担负“投资者”与“治理者”的双重角色,按照契约规定主动参与和监督企业的经营决策,发挥其应有的公司治理效应。     

论建筑工程项目成本的控制

改革开放以来,我国建筑工程项目不断增加,但是一些单位和部门对建筑工程项目的成本管理认识不到位,造成了不必要的浪费或损失,因此建筑企业必须严格控制建筑工程项目成本,实现社会效益和经济效益双丰收     

Information costs and liquidity effects from changes in the FTSE 100 list

Abstract

In this paper we examine the stock price effect of changes in the composition of the FTSE 100 over the time period of 1984–2001. Like the S&P 500 listing studies, we find that the price and trading volume of newly listed firms increases. The evidence is consistent with the information cost/liquidity explanation. This is because investors hold stocks with more available information, implying that they have lower trading costs. This explains the increase in the stock price and trading volume of newly listed stocks to the FTSE 100 List. We find the reverse effect for the deletions from the FTSE 100.