生物电子等排原理在新药设计中的应用

探索生物电子等排原理在新药研究中应用的规律,推动新药研究的进展;通过查阅文献资料,阐述生物电子等排的定义及各类生物电子等排的特点、使用范围、典型事例;表明生物电子等排既有外层电子总数相等的原子或基因的替换,也有在体积、形状、构象、电子分布、脂水分配系数、pKa、化学反应性(包括代谢相似性)和氢键成键能力等重要参数上存在相似性的原子或基团的替换,是对已知药物的结构改造或结构修饰;所产生新化合物优于、近于或拮抗原来药物的作用,具有成功率高、风险小、投资少的特点,在新药研究中占有重要的地位。应用生物电子等排体进行新药设计,尤其适合我国制药工业现有的实际情况。     

Term Structures in the Office Rental Market in Stockholm

This paper contains an empirical study of the rental term structure in a property market that included a dramatic boom and bust cycle. The study is applied to office leases in commercial properties located in Stockholm CBD, Sweden. The time period under study is 1977–1991. The number of observations (lease contracts) that we were able to make full use of in the regression analyses is n=861. For seven out of fifteen years studied, a significant term structure was observed. The estimated hedonic rent equation was also used to construct an office rental index.     

Uncertainty and Financing Constraints

Using a panel of Dutch listed firms this paper provides empirical evidence for the hypothesis that more risky firms are confronted with more severe capital market constraints than relatively less risky firms. The paper also contributes to the discussion on the usefulness of cash flow as a measure of financial constraints. We present a stochastic version of the Kaplan-Zingales (1997) model. We show that cash flow sensitivity can be used as a meaningful indicator of financing constraints if firms are classified by the degree of uncertainty they face and if the uncertainty originates from cost uncertainty.     

Antecedents and consequences of corporate governance reform: the case of Germany

The paper examines the antecedents and consequences of the voluntary adoption of corporate governance reform in firms embedded in a relationship‐based governance system with less protection of minority shareholders. In such locations, ownership structure should be a key determinant of governance reform. Firms with dispersed ownership are likely to face agency problems but may lack sufficient ownership power in the hand of external owners for adoption to occur. Extensive ownership by external parties facilitates adoption but decreases the need and motivation to adopt governance reform. We examined the adoption of stock‐based incentive plans and transparent accounting regulations (e.g., greater disclosure to shareholders) among large German firms (DAX 100) during the late 1990s. We found an inverse ‘U’‐shaped relationship between ownership concentration and governance reform. In addition, we found that firms adopting governance reform were more likely to engage in corporate divestitures and achieve higher levels of market performance than firms not adopting governance reform. Copyright © 2003 John Wiley & Sons, Ltd.     

Does the cost of capital differ across countries? An agency perspective*

In this keynote speech, I ask the question: Does the cost of capital differ for firms located in different countries? I argue that there are two ways to look at the cost of capital. First, there is the neoclassical perspective, which assumes that there are no agency problems. In integrated markets, the neoclassical cost of capital is the same in every country. Second, there is the agency perspective. Agency costs increase the cost of capital understood as the expected rate of return necessary for an investment to leave the value of the firm unaffected. Adjusting the cost of capital for agency costs, I argue that it differs across countries because of differences in corporate governance. I then provide a comparison of the agency-adjusted cost of capital between Japan and the US.     

发达国家金融结构演变的新趋势及其借鉴意义

本文使用全部私人市场资本化总量与全部私人信贷总量之比和股票市场资本化总量与存款货币银行信贷总量之比两大指标,来描述发达国家的金融结构;用金融发展总水平这一指标来描述发达国家金融发展的水平。无论从对23个样本国家时间序列数据的分析还是从结合金融发展的分析来看,发达国家金融结构演变都显示出了股票市场主导的金融市场融资比重增加和银行主导的金融中介融资比重下降的趋势。其中,少数发达国家出现了由中介为主体到由市场为主体逆转的趋势,和／或者出现了由银行为主导到由股票市场为主导逆转的趋势。作者还提出了这一新趋势对我国金融结构转变的借鉴意义。     

制度变迁内部动力机制分析

人们对需要和利益的追求是生产力发展和制度变迁的内在主体动因,生产力的发展是制度变迁社会进步的最终动力,只有以发展生产力为切入点才能从根本上推动制度变迁的进程。因此,制度变迁和具体制度安排的调整要以满足人们的需要为出发点,以尊重每个人切身利益为主要手段,才能充分调动制度变迁主体的积极性和内在动力。     

中国的经济增长、需求约束与税收结构

在我国目前的经济增长中,出现了投资需求过热而消费需求不足的结构性失衡状况。为此,可以把税收结构引入汉森-萨缪尔森模型,来研究税收结构对投资和消费的影响。通过实证研究发现,在税收结构中,流转税(间接税)比重的增加对投资增长有激励作用,而对边际消费倾向没有显著影响;所得税和其他税(代表了直接税)比重的增加,有利于抑制投资和过快的经济增长,相反,可以提高边际消费倾向,从而促进消费。     

独立董事报酬水平和薪酬结构设计分析

目前，我国独立董事薪酬制度存在严重的效率问题。研究发现，最优薪酬水平取决于独立董事的风险偏好、收入预期、工作能力和生产函数；最优薪酬结构取决于独立董事的风险偏好、收入预期，与其工作能力和生产函数无关；风险厌恶程度较高的独立董事适宜偏重货币工资激励。