黄连温胆汤的临床研究进展

综述了近10年来黄连温胆汤的临床研究进展,如治疗精神疾病、消化系统疾病、代谢疾病、慢性肾功能衰竭、心血管疾病、五官科疾病等,为黄连温胆汤的深入研究和合理应用提供依据。     

美国次级房贷及其抵押债券危机的成因分析

始于2007年初的美国次级债务问题愈演愈烈,好几家大公司和七十多家对冲基金深陷其中,对全球金融市场带来一次又一次的冲击。本文从美国次级住房贷款市场的发展、信用特征、风险度量等三方面探讨次债危机发生的原因、可能的影响及教训。本文认为,次级房贷及相关的住房抵押债券本身属于高风险资产,并且难以准确定价,风险溢价偏低致使金融机构对损失准备不够充足;美国宏观经济发展减速使得地产价格下跌更是加速了风险的释放。美国顶级金融机构深陷次债危机之中,承受巨大经济损失,再次表明风险管理不容忽视。     

Administrative cooperation and disease control in cross-border pork production

In recent years, the continuous structural change in the value chain of modern food production has been characterised by an increasing international division of labour among manufacturing companies. A regional specialisation of primary agricultural production is especially apparent in meat production. Thus, the German–Dutch border area has developed into a region of unprecedented intensive pork production. While The Netherlands specialises in piglet production, the production of fattened pigs continues to grow in northwest Germany. As a result of this increasing transnational value chain development, German imports of Dutch piglets have risen continuously since 2000. However, this structural interweaving of pork production between The Netherlands and Germany has resulted in many new challenges for the cooperation between the various participants and in particular for the administrative authorities in the field of food and feed safety as well as efficient animal disease control. The motivation for this exploratory study stems from the lack of scientific work on this topic to date. The aim of this research is to illustrate the relevance of functioning cross-border cooperation in the food sector, using commodity flow structures and disease spread analysis. Results indicate that cross-border cooperation between authorities during a CSF epidemic can reduce the risk of recurrence and the duration by 50%.     

Unintended Consequences of Lockdowns: Evidence from Domestic Helpers in Urban China

This paper addresses the reactions of domestic helpers to the Wuhan (Hubei Province) lockdown that began on January 23, 2020. We use a novel dataset containing the information of over 40,000 Chinese domestic helpers registered on a leading professional website from November 2019 to June 2020. The results indicate a declining pattern of short-term labor supply of domestic helpers across 11 major Chinese cities, which shows an increase in the expected monthly wage of domestic helpers in these cities. More importantly, using a difference-in-difference (DID) model, this paper provides some evidence on the existence of labor market discrimination against domestic helpers born in Hubei Province due to employers’ fear of infection.     

中国证券市场监管困境的原因分析

中国证券市场上诸多混乱现象的出现使证券市场的健康发展备受困扰,证券市场监管陷入困境之中.证券市场监管陷入这些困境的直接原因在于政府监管承载过重,范围过宽,导致力不从心;法律监管执法不力,推脱责任,导致威慑失效;自律监管力量微薄,碌碌无为,形同虚设;社会监管不遗余力,但是茫然无助,效果有限.证券市场监管陷入困境的最根本原因是证券市场的制度性扭曲.     

Perceptions of predictive testing for those at risk of developing a chronic inflammatory disease: a meta-synthesis of qualitative studies*

Background: The availability of tests to predict the risk of developing chronic diseases is increasing. The identification of individuals at high risk of disease can trigger early intervention to reduce the risk of disease and its severity. In order for predictive tests to be accepted and used by those at risk, there is a need to understand people’s perceptions of predictive testing. Method: A meta-synthesis of qualitative research that explored patient and public perceptions of predictive testing for chronic inflammatory diseases was conducted. Studies were coded by researchers and patient research partners, and then organised into common themes associated with the acceptability or use of predictive testing. Results: Perceived barriers to predictive testing were identified, including a concern about a lack of confidentiality around the use of risk information; a lack of motivation for change; poor communication of information; and a possible impact on emotional well-being. In order to reduce these barriers, the literature shows that a patient-centred approach is required at each stage of the testing process. This includes the consideration of individual needs, such as accessibility and building motivation for change; readily available and easy to understand pre and post-test information; support for patients on how to deal with the implications of their results; and the development of condition specific lifestyle intervention programmes to facilitate sustainable lifestyle changes. Conclusion: Patients and members of the public had some concerns about predictive testing; however, a number of strategies to reduce barriers and increase acceptability are available. Further research is required to inform the development of a resource that supports the individual to make an informed decision about whether to engage in a predictive test, what test results mean, and how to access post-test support.     

公路水毁成因及其防治措施

公路水毁主要有路基坍塌、路基沉陷、防护与加固工程损坏、桥涵破坏等4种类型详细阐述了各类水毁发生的原因以及探讨对各类水毁的防治措施。     

论水泥混凝土路面病害原因及防治对策

文章详细分析了水泥混凝土路面病害的类型及产生的原因,并在此基础上总结了水泥混凝土路面病害的防治对策。     

Cost-effectiveness of droxidopa in patients with neurogenic orthostatic hypotension: post-hoc economic analysis of Phase 3 clinical trial data

Objective:

Falls are associated with neurogenic orthostatic hypotension (nOH) and are an economic burden on the US healthcare system. Droxidopa is approved by the US FDA to treat symptomatic nOH. This study estimates the cost-effectiveness of droxidopa vs standard of care from a US payer perspective.

Methods:

A Markov model was used to predict numbers of falls and treatment responses using data from a randomized, double-blind trial of patients with Parkinson’s disease and nOH who received optimized droxidopa therapy or placebo for 8 weeks. The severity of falls, utility values, and injury-related costs were derived from published studies. Model outcomes included number of falls, number of quality-adjusted life-years (QALYs), and direct costs. Incremental cost-effectiveness ratios (ICERs) were calculated. Outcomes were extrapolated over 12 months.

Results:

Patients receiving droxidopa had fewer falls compared with those receiving standard of care and gained 0.33 QALYs/patient. Estimated droxidopa costs were $30,112, with estimated cost savings resulting from fall avoidance of $14,574 over 12 months. Droxidopa was cost-effective vs standard of care, with ICERs of $47,001/QALY gained, $24,866 per avoided fall with moderate/major injury, and $1559 per avoided fall with no/minor injury. The main drivers were fall probabilities and fear of fall-related inputs.

Limitations:

A limitation of the current study is the reliance on falls data from a randomized controlled trial where the placebo group served as the proxy for standard of care. Data from a larger patient population, reflecting ‘real-life’ patient use and/or comparison with other agents used to treat nOH, would have been a useful complement, but these data were not available.

Conclusion:

Using Markov modeling, droxidopa appears to be a cost-effective option compared with standard of care in US clinical practice for the treatment of nOH.