关于前海深港现代服务业合作区发展路径的思考

前海合作区深港合作,香港期盼的核心利益是,以前海为平台,优先进入中国大陆服务市场;深圳则可充分利用香港的优势,通过微观层面的企业合作促进产业结构升级,通过宏观层面的管理合作促进体制机制创新。政策拟定时应转变过去重点依赖税收优惠的思路,应重点从服务业市场准入、体制机制创新、人才环境等方面给予政策支持。     

从财政分权看我国地方政府发行公债的必要性

举债权是规范的分税制赋予地方政府应有的财权。在财政分权的框架下,一级政权,一级事权,一级财权是题中之义。本文首先从财政分权理论出发,指出发行市政债是地方融资平台的替代措施。     

大东金沙江大桥设计方案

大东金沙江大桥跨越金沙江,结合受控因素其主桥设置为1520m双塔单跨钢桁梁悬索桥.索塔采用门型框架结构,横梁为预应力混凝土结构.加劲梁采用板桁结合钢桁梁,以适应山区受限的施工场地,桁高9.5m,弦杆水平中心距31m.主缆采用预制平行钢丝索股,骑跨式索夹及吊索.两岸锚碇为隧道锚,其中一岸设置缆洞索股入山.引桥采用钢混组合...     

技术竞争导向下的创新投入与企业成长性——来自科技型中小微企业的调查数据

基于我国科技型中小微企业的调查问卷数据,本文研究了创新投入与企业成长的关系和作用机理,并探讨了内外部创新环境对二者关系的异质性影响.研究结果表明,创新投入与科技型中小微企业成长性正相关;进一步研究发现,提高竞争优势和降低外部融资约束是创新投入影响科技型中小微企业成长性的中介路径;内部知识吸收和外部创新共享具有调节效应,...     

重大疫情对应急物流系统建设的启示

新型冠状病毒引发重大疫情,暴露出众多的物流问题,针对“急”和“乱”这两个应急物流的主要特点,从业务、管理(执行)、技术三个层面提出建设应急物流系统的新思想,即采用平战结合、军民融合的建设方法,重点建设全国统一的应急响应物流信息平台,运用大数据、AI等技术手段,快速完成物流需求分析,充分应用自动化、智能化和无人机、机器人等先进技术手段,培养一支技术全面的国家队伍,完成应急物流的快速响应。     

“三链对接,双元协同,多方共享”的产教融合育人平台的搭建与实践

针对目前职业教育产教融合综合指数不高、学生硬核实力与实际岗位脱节、教师四大职能与行业企业实践脱节以及育人目标与产业需求存在“隐形壁垒”等问题,对接产业链、人才链和创新链,校企双方从专业组建、基地建设、课程开发、技术创新、团队打造、人才培养等方面协同共建,构建了多方共享的产教融合育人平台,打造产教融合型的命运共同体。     

A supplier evaluation model based on customer demand in blockchain tracing anti-counterfeiting platform project management

This study assesses supplier selection at the beginning of project management to establish an evaluation system corresponding to blockchain tracing anti-counterfeiting platforms (BTAP). First, this paper determines 20 evaluation criteria from the four dimensions of platform overview, core technology, application support, and operations management. On this basis, multi-criteria decision making (MCDM) based on customer needs is proposed, which consists of three main steps. First, quality function deployment (QFD) and the best and worst method (BWM) are used to evaluate the four dimensions of the BTAP and specific evaluation criteria from the perspective of customers to obtain the criteria weight. Then, this method uses the extended Vlse Kriterjumska Optimizacija I Kompromisno Resenje (VIKOR) approach to sort the alternatives. Finally, the improved decision making trial and evaluation laboratory (DEMATEL) method is used to analyse the relationships between the 20 criteria in the four dimensions. The feasibility and effectiveness of this method are verified by an example. According to the sensitivity analysis and comparative analysis, the results show that this method can evaluate blockchain anti-counterfeiting enterprises. The main conclusions are as follows: the core technology is the most important factor influencing the choice of a BTAP project, and the role of application support in evaluation cannot be ignored.     

跨行政区域协同创新界面管理研究

研究跨行政区域界面管理问题,对于实现协同目标、提升协同绩效具有重要意义。本文主要研究跨行政区域协同创新界面类型、成因,应对界面障碍策略等问题。结果表明,从协同创新演化及其协同机理来看,跨行政区域主体协同创新界面可以分为内外界面两类;跨行政区域协同创新形成的界面主要有制度、知识、技术、交易、组织和管理等表现形式,起因为界面对应的壁垒。最后提出通过构建协同创新平台来解决跨行政区域协同创新界面障碍的设想,设计了平台形式、结构及其运行机制。     

Economic modeling for the US of the cost-efficiency and associated expanded treatment access of conversion to biosimilar pegfilgrastim-bmez from reference pegfilgrastim

Abstract

Aims: For this economic analysis, we aimed to model: (1) the cost-efficiency of prophylaxis with biosimilar pegfilgrastim-bmez for chemotherapy-induced (febrile) neutropenia (CIN/FN) compared to reference pegfilgrastim, and (2) the expanded access to CIN/FN prophylaxis and anti-neoplastic treatment that could be achieved with biosimilar cost-savings on a budget-neutral basis.

Methods: In a hypothetical panel of 20,000 cancer patients receiving CIN/FN prophylaxis and using the average sales price (ASP) for the second quarter of 2019 for reference pegfilgrastim, we: conducted an ex ante simulation from the payer perspective of the cost-savings of 10–100% conversion from reference to biosimilar pegfilgrastim-bmez using drug price discounting ranging from 10–35%; estimated the budget-neutral expanded access to biosimilar pegfilgrastim-bmez enabled by these cost-savings; and estimated the budget-neutral expanded access to anti-neoplastic treatment with pembrolizumab. The simulations were replicated using fourth quarter 2019 wholesale acquisition cost (WAC) for reference pegfilgrastim and biosimilar pegfilgrastim-bmez in a post facto analysis.

Results: In ASP simulations, cost-savings of using pegfilgrastim-bmez over reference pegfilgrastim in a 20,000 patient panel range from $1.3?M (at 15% price discount) to $3?M (35%) at 10% conversion rate and from $6.4?M to $14.9?M, respectively, at 50% conversion. These savings could provide prophylaxis with pegfilgrastim-bmez to an additional 352 (15% discount) to 1,076 patients (35%) at 10% conversion or 1,764–5,384, respectively, at 50% conversion. Alternatively, savings could be reallocated for anti-neoplastic treatment with pembrolizumab to 3 (15% discount) to 9 (35%) patients at 10% conversion or 19–45, respectively, at 50% conversion. When utilizing WAC, cost-savings range from $4.6?M (10% conversion) to $23.1?M (50%) which could provide pegfilgrastim-bmez to an additional 1,174 (10% conversion) to 5,873 patients (50%).

Conclusions: Prophylaxis with biosimilar pegfilgrastim-bmez increases the value of cancer care by generating significant cost-savings that could be reallocated to provide expanded access to CIN/FN prevention and anti-neoplastic therapy on a budget-neutral basis.     

管理会计在VBSE实践教学平台中的创新应用研究--基于高职会计技能大赛管理会计赛项视角

数字经济时代下各行业经营环境愈加复杂,传统的财务会计已经无法有效满足企业内部管理的需要,急需向管理会计方向转型。VBSE实践教学平台通过模拟企业真实经营环境让更多学生有机会感受和体验公司财务工作,但其内容仍然以会计核算、纳税申报、报表编制等传统知识点为主,缺少管理会计方面的分析、预测、战略制定等经营管理决策活动的内容设计。以高职会计技能大赛管理会计赛项为视角,分别从资金、营运、成本和绩效四个岗位研究管理会计在VBSE实践教学平台中的融入和创新应用,旨在完善VBSE实践教学平台中的管理会计建设,培养更多管理会计人才。