Health status,function, productivity,and costs among individuals with idiopathic painful peripheral neuropathy with small fiber involvement in the United States: results from a retrospective chart review and cross-sectional survey

Objective:

To characterize the burden of idiopathic painful peripheral neuropathy with small fiber involvement (idiopathic SFN) by pain severity in the US.

Methods:

One hundred previously diagnosed idiopathic SFN subjects were enrolled during routine office visits. Subjects completed a one-time questionnaire, and investigators reported clinical characteristics and healthcare resource use, based on 6 month retrospective chart review. Annualized direct and indirect costs were estimated. Results were stratified across pain severity groups.

Results:

Mean age was 63.5 years; 53.0% were female; 76.0% had moderate or severe pain. Most common comorbidities were sleep disturbance/insomnia (37.0%), anxiety (34.0%), and depressive symptoms (33.0%). Overall mean health status (0.59; ?0.11–1.00 scale), physical and mental health (31.7 and 45.6, respectively, 0–100 scale), sleep index (45.1; 0–100 scale), and pain interference with function (5.0; 0–10 scale) differed by pain severity, with worse outcomes among those with greater pain (all p?Conclusions:

Idiopathic SFN subjects with pain experience moderate or severe pain, which negatively impacts health status, function, and productivity, and leads to substantial direct and indirect costs.     

From core to periphery and back: A study on the deliberate shaping of knowledge flows in interfirm dyads and networks

We study 892 Italian motorcycle industry projects carried out via 184 different buyer–supplier and supplier‐supplier relationships to provide evidence on the knowledge dynamics occurring in dyads and networks and to understand the underexplored but important (perhaps even dominant) leading role that some firms play in the evolution of networks and interfirm learning processes. We develop a multiphase model which, from a multilevel perspective addressing different relational subsets, suggests how firms can best organize to generate and exchange knowledge efficiently. We argue that extant theoretical perspectives can profitably draw on our findings to strengthen their dynamic components and help them explain the widely diffused ‘exploring through partner’ strategies more effectively. Copyright © 2013 John Wiley & Sons, Ltd.     

Putting policy into practice: an exploratory study of SME innovation support in a peripheral UK region

Abstract

Focussing on a regional Government sponsored support programme for technology-based small and medium-sized enterprises (SMEs), the aim of this paper is to conduct a multi-level exploration of the relationships between policy interpretation and support programme design and the development of innovation capability among participant SMEs within a U.K peripheral region. The Innovplus programme was designed and implemented in Northern Ireland to help nascent high technology companies become more competitive and to contribute to the goals of the Regional Innovation Strategy. A knowledge-based absorptive capacity framework is used as the theoretical lens to explore the relationships between policy interpretation and programme design and the development of innovation capability within participant SMEs. The findings show that the design of the Innovplus programme, while linked to a coherent Regional Innovation Strategy, lacks consistency in relation to the policy and practical interpretation of knowledge and innovation. This inconsistency is reflected in the practical design of the programme, limiting its effectiveness as a result. In terms of the development of innovation capability, it was found that recognition and development of nascent absorptive capacity drivers in potential form was essential before participant SMEs could transition to realised absorptive capacity.     

前列地尔联合厄贝沙坦治疗糖尿病肾病患者的临床效果

目的 探讨前列地尔联合厄贝沙坦治疗糖尿病肾病患者的临床效果.方法 选取2018年2月至2020年2月在辽宁省精神卫生中心进行药物治疗的94例糖尿病肾病患者作为研究对象,随机分为对照组与观察组,每组47例.对照组采用厄贝沙坦片进行治疗,观察组采用前列地尔联合厄贝沙坦片进行治疗.比较两组治疗有效率、药物不良反应发生率、血糖...