人类后基因组研究进展

人类对自身基因组的研究不断发展，已从结构基因组学转向功能基因组学阶段。本文概述了人类后基因组的研究内容及进展状况。     

The visible hand: the role of government in China’s long-awaited industrial revolution

China is undergoing its long-awaited industrial revolution. There is no shortage of commentary and opinion on this dramatic period, but few have attempted to provide a coherent, in-depth, political-economic framework that explains the fundamental mechanisms behind China’s rapid industrialization. This article reviews the Embryonic Economic Development theory put forth by Wen (2016a). This article reviews the Embryonic Economic Development theory put forth by Wen . It illuminates the critical sequence of developmental stages since the reforms enacted by Deng Xiaoping in 1978: namely, small-scale commercialized agricultural production, proto-industrialization in the countryside, a formal industrial revolution based on mass production of labor-intensive light consumer goods, a sustainable ‘industrial trinity’ boom in energy/motive power/infrastructure, and a second industrial revolution involving the mass production of heavy industrial goods. This developmental sequence follows essentially the same pattern as Great Britain’s Industrial Revolution, despite sharp differences in political and institutional conditions. One of the key conclusions exemplified by China’s economic rise is that the extent of industrialization is limited by the extent of the market. One of the key strategies behind the creation and nurturing of a continually growing market in China is based on this premise: The free market is a public good that is very costly for nations to create and support. Market creation requires a powerful ‘mercantilist’ state and the correct sequence of developmental stages; China has been successfully accomplishing its industrialization through these stages, backed by measured, targeted reforms and direct participation from its central and local governments.     

综合治疗方案在中晚期宫颈癌中的应用

观察综合方案治疗中晚期宫颈癌的近远期疗效,探索这一治疗方案在中晚期宫颈癌治疗中的应用价值。     

论颈椎间盘突出症患者的非手术及理疗

本文主要探讨了椎间盘病学特征、病理特征、临床分型、临床症状与表现、非手术及治疗以及康复治疗的一些实际问题。     

瑞舒伐他汀与替格瑞洛联合用药方案治疗非ST段抬高型急性冠脉综合征患者的临床效果及不良反应

目的探讨瑞舒伐他汀与替格瑞洛联合用药方案治疗非ST段抬高型急性冠脉综合征(ACS)患者的临床效果及不良反应。方法选取2018年1月至2019年7月沈阳积水潭医院收治的70例非ST段抬高型ACS患者作为研究对象,依据随机数字表法分为对照组和观察组,每组35例。对照组采用替格瑞洛治疗,观察组采用瑞舒伐他汀与替格瑞洛联合用药方案治疗,比较两组临床疗效、心肌损伤指标、炎症介质水平、不良反应发生率。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05);观察组肌酸激酶同工酶、肌钙蛋白水平低于对照组,差异有统计学意义(P<0.05);观察组炎症介质水平、不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论瑞舒伐他汀与替格瑞洛联合用药方案治疗非ST段抬高型ACS临床效果显著,不仅可以改善临床相关指标、心肌损伤,还可减轻炎症反应,且不良反应发生率低。     

Are property rights enough?Re‐evaluating a big‐bang claim1

We investigate the claim made by proponents of the big‐bang strategy that the establishment of property rights in an economy in transition creates its own demand for the enforcement of laws to protect those rights. Our model contains a government engaging in activities to accomplish objectives that depend on public support for the enforcement of the rule of law and agents who interpret the level of activities of the government as indications of the government's intent to enforce the rule of law. Agents, using the level of government activities as an input to their decisions, choose whether to support the government's objectives. We establish conditions under which the level of activities chosen by the government maximizes its benefits, and simultaneously induces the constituency to support enforcement of the rule of law. These conditions provide a basis for the argument for the implementation of the big‐bang policy. When these conditions do not hold, however, we show that the level of activities that maximizes the government's benefits may have only a minor impact on support for the enforcement of the rule of law. Two characteristics play an important role in these conditions: the initial level of crime and the types of activities the government chooses to undertake. We present examples showing that the initial level of crime has the more dramatic effect on subsequent support for the rule of law.     

Converging scientific fields and new technological paradigms as main drivers of the division of scientific labour in drug discovery process: the effects on strategic management of the R&D corporate change

The thesis of this study is that the convergence of genetics, genomics and proteomics spurs new technological paradigms in medicine, which are generating a R&D corporate change: division of scientific labour of the drug discovery process by strategic alliances among firms in order to reinforce the integrative capabilities in different biomedical research fields and collective and cumulative learning between in-house R&D and external sources of innovation. This study shows, by key a case study of pharmaceutical companies, as scientific and technological paradigms in medicine are main drivers of industrial and R&D corporate change to enhance and accelerate the discovery process of ground-breaking drugs for more and more personalised healthcare.     

高校辅导员不良情绪行为的自我管理

受一些现实与心理因素的影响，部分高校辅导员对学生产生了一系列不良情绪与行为；这些不良情绪与行为会促使学生产生不良的自我概念。辅导员的不良情绪与行为的真正原因，是他们对诱发性事件不正确的解释与评价，即“不合理信念”。辅导员应学会自我诊断，挖掘不合理信念，合理自我分析，并培养情绪分析习惯，以实现辅导员对自身不良情绪与行为的自我管理。     

药物防治高危孕妇产后出血的临床疗效

目的探讨相关药物治疗高危孕妇产后出血的临床疗效。方法选取高危剖宫产及有产后出血因素的孕妇60例,随机分为3组。A组孕妇分娩后在正常缩宫素的基础上采用舌下含服米索前列醇片进行治疗;B组孕妇分娩后在正常缩宫素的基础上注射卡前列素氨丁三醇注射液250μg,C组孕妇分娩后在正常缩宫素的基础上加用缩宫素。比较3组患者的治疗效果。结果 A组与B组孕妇的产后出血率均小于C组,差异有统计学意义(P<0.05)。结论米索前列醇片与卡前列素氨丁三醇注射液用于孕妇产后出血疗效较佳,安全有效。     

左氧氟沙星三联疗法与阿莫西林三联疗法治疗消化性溃疡的临床疗效

目的探讨左氧氟沙星三联疗法与阿莫西林三联疗法治疗消化性溃疡的临床疗效。方法选取我院收治的消化性溃疡患者124例,将其随机分为两组,治疗组患者采用左氧氟沙星三联疗法,对照组患者采用阿莫西林三联疗法;比较两组患者的临床疗效及不良反应。结果治疗组患者总有效率为90.3%,明显优于对照组患者的83.9%,组间比较差异有统计学意义(P<0.05);治疗组不良反应发生率为8.1%,对照组不良反应发生率为11.3%,两组比较差异无统计学意义(P>0.05)。结论左氧氟沙星三联疗法治疗消化性溃疡的临床疗效明显,具有安全、经济、不良反应少等优点。