天津滨海新区物流信息平台系统框架研究

在对天津滨海新区的发展趋势以及国内外相关系统分析的基础上,针对天津滨海新区对公共物流信息平台的需求,对其物流信息平台的系统框架进行了设计。     

加入WTO会计信息诚信极待加强

加入WTO后会计信息的披露要城信至上、不做假账，如果会计信息失信，危害极大。本文提出具有可操作性的提高会计信息诚信的对策。     

A review and validation of overall survival extrapolation in health technology assessments of cancer immunotherapy by the National Institute for Health and Care Excellence: how did the initial best estimate compare to trial data subsequently made available?

Background: Validation of overall survival (OS) extrapolations of immune-checkpoint inhibitors (ICIs) during the National Institute for Health and Care Excellence (NICE) Single Technology Assessment (STA) process is limited due to data still maturing at the time of submission. Inaccurate extrapolation may lead to inappropriate decision-making. The availability of more mature trial data facilitates a retrospective analysis of the plausibility and validity of initial extrapolations. This study compares these extrapolations to subsequently available longer-term data.

Methods: A systematic search of completed NICE appraisals of ICIs from March 2000 to December 2017 was performed. A targeted search was also undertaken to procure published OS data from the pivotal clinical trials for each identified STA made available post-submission to NICE. Initial Kaplan-Meier curves and associated extrapolations from NICE documentation were extracted to compare the accuracy of OS projections versus the most mature data.

Results: The review identified 11 STAs, of which 10 provided OS data upon submission to NICE. The extrapolations undertaken considered parametric or piecewise survival models. Additional data cut-offs provided a mean of 18 months of OS beyond the end of the original data. Initial extrapolations typically under-estimated OS from the most mature data cut-off by 0.4–2.7%, depending on the choice of assessment method and use of the manufacturer- or ERG-preferred extrapolation.

Conclusion: Long-term extrapolation of OS is required for NICE STAs based on initial immature OS data. The results of this study demonstrate that the initial OS extrapolations employed by manufacturers and ERGs generally predicted OS reasonably well when compared to more mature data (when available), although on average they appeared to underestimate OS. This review and validation shows that, while the choice of OS extrapolation is uncertain, the methods adopted are generally aligned with later-published follow-up data and appear appropriate for informing HTA decisions.     

逆向选择条件下技术许可中非排他性价格契约研究

通过经典的委托代理理论的应用,文章揭示了一类逆向选择条件下的技术许可中非排他性价格契约理论的内在机理。文章认为,通过针对差的类型的技术使用者的包含可变费用的契约和对好的类型的技术使用者的纯固定费用的契约,可以达到有效的排他性技术许可的目的;但为了有效的激励,技术所有者事前要对好的类型的技术使用者转移一定的信息租。     

全球化背景下以动态比较优势实现产业技术跨越

全球化背景下中国失去了采用传统保护手段来培育动态比较优势，而面对新的机遇和挑战，中国应立足于自身资源禀赋的比较优势，在某些产业的关键环节选择技术跨越来培育动态比较优势；并通过发展高新技术、加强对传统产业的技术改造和提高技术引进效果来有效实施技术跨越，在一定程度上占据国际分工制高点。     

中小企业技术创新的制约因素及其对策研究

中小企业作为推广使用高新技术的第一阵地 ,在技术创新过程中扮演着极其重要的角色。但目前 ,中国中小企业在技术创新活动中却受到诸多因素的制约 ,因此 ,本文在具体剖析了中小企业技术创新障碍的基础上 ,提出了提升其技术创新能力及优化其创新环境的若干对策。     

产品内贸易、技术创新与中国企业可持续发展

在科技革命和经济全球化的共同作用下，特别是随着FDI的增长和跨国公司的全球布点，传统意义上的以商品贸易为基础的国际分工正在被打破，国际分工逐步深入到企业内部，分工方式由产业间分工向产业内部产品分工和要素分工延伸。本文以当前新贸易现象为实践基础，以贸易分工理论为理论基础，初步构建产品内贸易的理论模型及其利益分配机制，从产品内分工视角分析产品内贸易模式对发展中国家贸易条件的影响，并认为中国企业应该在国际分工价值链上进行攀升，进行技术创新，提升在国际贸易中的地位，化比较优势为竞争优势，实现企业的可持续发展。     

基于旅游者和日常访问者人群行为的城市型景区“共处”空间研究

针对城市型景区内旅游者和日常访问者相互影响的现象，提出“共处”空间概念，从“空间-行为”关系视角总结“共处”空间的时空特性，形成“共处”空间判别依据。基于计算机视觉技术，通过问卷调查，将人群行为划分为互不干扰、围观及参与、干扰及冲突3类，从空间优化与管理角度对列入公园年票体系中的城市型景区提出建议，梳理2类人群关系，提高游憩体验质量。     

从大中型企业的科技发展现状看新疆科技改革

在"科教兴新"战略的指引下,加快新疆科技改革已成为各方共识.新疆大中型企业的科技发展现状反映出新疆的科技发展存在不少问题.以市场为导向,以科技企业为载体,加大科技开发力度,建立适应经济发展的科技投入体系,提高专利技术转化率是解决诸多问题的重要对策.     

网络信息资源与信息服务

本文从网络信息资源的特点及现状去探讨解决信息服务相对应的几个问题。