高速公路运营隧道病害整治探讨

本文结合工程实例,根据隧道病害情况和隧道检测报告,利用Midas GTS对隧道衬砌结构的变形和内力进行分析,探讨隧道相关整治措施,对已通车运营的隧道进行整治,以期为隧道病害治理工作提供参考。     

Evaluating drug cost per responder and number needed to treat associated with lixisenatide on top of glargine when compared to rapid-acting insulin intensification regimens on top of glargine,in patients with type 2 diabetes in the UK,Italy, and Spain

Objectives: This study investigated the cost per responder and number needed to treat (NNT) in type 2 diabetes mellitus (T2DM) patients for lixisenatide compared to insulin intensification regimens using composite endpoints in the UK, Italy, and Spain.

Methods: Efficacy and safety outcomes were obtained from GetGoal Duo-2, a 26-week phase 3 trial comparing lixisenatide vs insulin glulisine (IG) once daily (QD) and three times daily (TID). Response at week 26 was extrapolated to 52 weeks, assuming a maintained treatment effect, based on long-term evidence in other T2DM populations. Responders were defined using composite end-points, based on an HbA1c threshold and/or no weight gain and/or no hypoglycemia. The HbA1c threshold was varied in sensitivity analyses. Annual treatment costs were estimated in euros (1 GBP?=?1.26 EUR), including drug acquisition and resource use costs. Cost per responder was computed by dividing annual treatment costs per patient by the proportion of responders.

Results: Lixisenatide was associated with the lowest cost per responder for all composite end-points that included a weight-related component. For the main composite end-point of HbA1c ≤7.5% AND no weight gain AND no symptomatic hypoglycemia, cost per responder results were: UK: 6,867€, 8,746€, and 12,410€; Italy: 7,057€, 9,160€, and 12,844€; Spain: 8,370€, 11,365€, and 17,038€, for lixisenatide, IG QD, and TID, respectively. The NNT analysis showed that, for every 6.85 and 5.86 patients treated with lixisenatide, there was approximately one additional responder compared to IG QD and TID, respectively.

Limitations: A limitation of the clinical inputs is the lack of 52-week trial data from GetGoal Duo-2, which led to the assumption of a maintained treatment effect from week 26 to 52.

Conclusions: This analysis suggests lixisenatide is an efficient economic resource allocation in the UK, Italy, and Spain.     

核心企业集约的多产品、多级供应链库存控制策略研究

在供应链环境及结构稳定情况下,供应链上的各节点企业,根据需求来调整相应的运作策略。基于多层供应商及供货产品为多品种且集约到一个核心企业的供应链网络,根据该供应链网络供需结构和特点分析了各节点的需求特征,得出了订货提前期为随机条件下的最佳库存费用,并利用各节点服务水平约束下的临界值及库存费用凸函数特性确定了供应链的运作策略。     

Unveiling covariate inclusion structures in economic growth regressions using latent class analysis

We propose the use of Latent Class Analysis methods to analyze the covariate inclusion patterns across specifications resulting from Bayesian model averaging exercises. Using Dirichlet Process clustering, we are able to identify and describe dependency structures among variables in terms of inclusion in the specifications that compose the model space. We apply the method to two datasets of potential determinants of economic growth. Clustering the posterior covariate inclusion structure of the model space formed by linear regression models reveals interesting patterns of complementarity and substitutability across economic growth determinants.     

Wage Inequality and Wage Mobility in Europe

Using data from the European Union Statistics on Income and Living Conditions, this paper investigates wage inequality and wage mobility in Europe. Decomposing inequality into within‐ and between‐group inequality, we analyze to what extent wage inequality and mobility can be explained by observable characteristics. Furthermore, we investigate which individual and household characteristics determine transitions within the wage distribution. We find that overall, mobility reduces wage inequality. While a large part of wage inequality is due to unobservable characteristics, the equalizing effect of mobility mainly occurs within groups. Furthermore, both personal and household characteristics play an important role for wage transitions. Finally, our findings reveal large cross‐country differences across Europe.     

基于PSR模型的广东省城市土地集约利用空间差异分析

将＂压力—状态—响应＂框架引入到城市土地集约利用评价指标体系中,采用主成分分析方法对评价指标进行赋权,对广东省21个地级市的城市土地集约利用水平进行了评价。结果表明,广东省城市土地利用集约度差异形成的主要影响因素是地理区位条件和经济发展水平,资源赋存状况也是重要的制约条件。城市土地集约利用是一个复杂的系统工程,不仅要注重提高土地利用的产出效益,还要重视系统压力状态的调节和系统反馈能力建设。研究也表明,PSR评价指标体系及主成分分析方法能较好地适应城市土地集约利用评价的需要。     

The architecture of R&D joint projects: the social network analysis approach

This paper examines the effect of network properties on the performance R&D joint projects. In particular, we examine the impact of network cohesion, diversity and shape on the performance of these of exploration and exploitation R&D projects. We test these measures using data on projects from European R&D networks developed under the framework of Eureka projects. The empirical results indicated some network properties enhance the project’s performance and these differ depending on the kind of technological project developed. Our results suggest a lower heterogeneity, greater cohesion and network centralisation in exploitation than in exploration projects. Our findings show different types of structures depending on the aim of the joint project and that there exist different degrees of cohesion between the partners that comprise the core and the peripheral nodes.     

中国各地区就业质量测算与评价

基于公开出版的官方的统计年鉴数据,本文构建了一个包括了6个维度指标、20个二级指标和50个三级指标的就业质量评价指标体系,使用主成分分析法对中国大陆30个省份的就业质量状况进行了测算。结果表明,在2007年、2008年这两个年份,除少数经济发达省份外,全国就业质量的总体水平不高,大部分省份的就业质量指数较低;地区间就业质量差异明显,发展不协调;随着经济发展,地区间就业质量差异逐步缩小。由于就业环境改善是提高就业质量的基础,所以实现经济发展向高就业、高报酬、高消费型发展方式的转变,加快中西部地区经济发展,逐步缩小地区间经济发展水平的差异,是缩小就业质量差异的根本途径。同时,还应加强人力资本投资;切实保障劳动者权益,促进三方协商机制的实施;必须通过完善相关制度建立地区间、城乡间高效一体的劳动力市场,这是实现平等就业,促进和谐发展的必然选择。     

基于BD-GIS耦合模型的北京奥林匹克 森林公园景观优化策略研究

随着城市人口的增加和人们健康意识的增强,近年 来城市公园的使用率呈现迅速上升趋势。手机等智能电子设备 的高速发展,使人们可以在户外运动中监测自身活动轨迹、距 离和能量消耗等。以北京奥林匹克森林公园为例,通过手机 信令、微博、百度POI等大数据与GIS技术结合,构建依托大 数据的GIS耦合模型,从游人的行为需求出发对公园的慢跑游 线、景点热度、游人空间分布等进行使用后量化评价,并针对 问题提出北京奥林匹克森林公园的景观优化策略。结果显示大 数据与GIS的结合可以为公园的景观优化提供客观且理性的整 改依据,从而更科学地指导城市公园的景观提升。