Budget impact analysis of secukinumab versus adalimumab in the treatment of ankylosing spondylitis

Background: Biologic treatments have enhanced the treatment outcomes of patients with active ankylosing spondylitis (AS). Until recently, TNF-alpha-inhibitors have been the only biologics approved for the treatment of active AS. The objective of this study was to assess the potential financial impact of the first non-TNF-alpha biologic secukinumab (fully human IL-17A-inhibitor) vs adalimumab (TNF-alpha-inhibitor) in the treatment of AS in Finland.

Materials and methods: In this model-based budget impact analysis, patients were treated either with secukinumab (150?mg) or adalimumab (40?mg). The number of patients and market share of different biologics were based on national reimbursement registry data. Adalimumab was the most commonly used biologic treatment for AS, and in the base case analysis all adalimumab patients are assumed to switch to secukinumab. Response rates were based on a matching-adjusted indirect comparison between secukinumab and adalimumab. Patients not achieving response were switched to another biologic treatment.

Results: Treating AS patients with secukinumab instead of adalimumab leads to potential savings of 18.2 million euros within a 5-year time period. The total costs within the follow-up time were 59.5 million euros and 77.7 million euros with and without secukinumab, respectively. According to sensitivity analyses, a higher adoption rate of secukinumab corresponds to higher potential savings.

Conclusions: Secukinumab is a cost-saving treatment option compared with adalimumab in the treatment of AS in Finland. More patients could be treated with a biologic by allocating resources more efficiently.     

两型社会建设中建设用地集约利用问题探讨——以长株潭城市群为分析对象

集约利用建设用地是长株潭土地资源利用机制创新的关键。长株潭城市群应以交通建设为契机,推广人车人流节地模式、开发园区土地集约模式等成功做法,建立节约集约利用建设土地约束机制,加强建设用地控制标准建设评价工作和相关配套制度建设和改革,推动长株潭城市群建设用地的集约利用。     

比利时利用生态税促进经济和社会可持续发展

比利时生态税措施在应对气候变化、减少温室气体排放、刺激经济和促进绿色就业等方面发挥着重要作用。本文介绍并分析了比利时生态税的三大目标,以及劳动税向能源税转移、发展节能型建筑、废除煤炭优惠税、鼓励低能耗交通、支持低能耗企业等多项具体措施。     

Keynes and Sraffa's 'Difficulties with J. H. Hollander'

The paper reports on Jacob H. Hollander's cooperation with John Maynard Keynes and Piero Sraffa in the preparation of the latter's edition of The Works and Correspondence of David Ricardo. The report is based on archive material from various sources, including the unpublished papers of Edwin Cannan, Piero Sraffa, Jacob H. Hollander, John Maynard Keynes, and Jacob Viner, and the archive of the Royal Economic Society. The archive material consulted by us shows that, put mildly, Jacob H. Hollander did not promote Sraffa's editorial project: he held back material which he had received from Frank Ricardo and did not disclose to Sraffa that he owned several important letters which he had privately purchased. Moreover, Sraffa was refused access to Ricardiana even after he had traced them down in laborious detective work to be in Hollander's possession. Hollander's unwillingness to cooperate with Sraffa considerably delayed the publication of the Ricardo edition.     

新时期中国经济学伦理问题思考

在构建社会主义和谐社会政治构想,以及关注民生、促进社会公平正义的社会发展目标提出来之后,确立新的和符合社会发展要求的经济学核心伦理,就成为中国经济科学发展的关键,而科学、客观地认识与经济科学伦理相关的种种中国经济现实问题,又是确立新时期中国经济科学伦理必须认真加以研究的重大课题。     

社会收入信息系统与基尼系数测算结果的可信度研究

基尼系数作为衡量居民收入分配不均等程度的有效指标,其结果可信与否受到测算方法以及样本数据两个因素的影响。本文从居民收入样本数据角度出发,通过分析我国基尼系数测算结果与实际情况存在差异的现实及原因,认为提高基尼系数测算结果可信度的当务之急是构建一个能够真实全面反映居民各项收入情况的社会收入信息系统。     

和谐社会、科学发展与统筹兼顾——迈向新改革时代的大国治理逻辑

改革开放以来,中国社会经济发展取得了举世瞩目的成就,但也产生了不少问题和矛盾。毫无疑问,中国经济发展已经到了一个关键时期。彻底冲破旧制度束缚的强烈需求必然催生中国新一轮的改革。在中共十七大精神的指引下,迈向新改革时代的大国治理必然以构建和谐社会为目标,以科学发展观为指导,以统筹兼顾为方法,引领整个社会走向全面协调可持续的发展轨道,从而实现民族复兴和大国崛起。     

汉杜陵雁塔区域发展大遗址文化产业集群构想

发展政府主导型大遗址文化产业集群是汉杜陵遗址区域实现大遗址保护与区域经济社会和谐发展的一条创新途径。文章以汉杜陵遗址区为例,对文化产业集群的条件、目标定位、产业定位、集群结构模式进行了分析研究,并指出了政府应尽的重要职责。     

充分就业是全面建设小康社会的基础

就业是民生之本。扩大就业是我国当前和今后长时期重大而艰巨的任务,也是全面建设小康社会的基础。十四届三中全会以来,我国就业成就显著,但劳动年龄人口多,就业压力大,矛盾突出,应采取积极的措施。     

浅谈会计信息失真

会计信息是经济管理的主要信息之一,是企业经营管理和科学决策的重要依据,也是国家经济进行宏观管理的重要思想来源。然而,我国的会计信息失真现象却大量存在,主要表现为帐外设帐、假帐真做、钻会计政策空子三方面,而企业内部管理失控、政府管理职能不规范和社会监督职能弱化、会计人员的综合素质不高是导致我国企业会计信息失真的主要原因。加强企业内部管理、加强政府管理职能和社会监督职能、提高工作人员综合素质是治理我国企业会计信息失真的有效途径。