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991.
相关数据显示,以国企投资为主的传统制造业产能过剩情况严重,国有企业也是产能过剩率先爆发的“重灾区”。探究国企投资冲动背后的深层次诱因,可归结为内部成本的外部化和国企产权不明晰两大原因。化解产能过剩必须建立起长效化解机制,一方面通过完善市场竞争机制来还原市场对资源配置的决定性作用,另一方面通过实质性地推进国企改革,来最终达到根治产能过剩的目的。 相似文献
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Ellis J. Neufeld Robert F. Sidonio Jr M. Chris Runken Kellie Meyer Jeffrey Spears 《Journal of medical economics》2018,21(8):762-769
Background: Inhibitor development to factor VIII (FVIII) hemophilia therapy results in increased complications and substantial economic costs. The SIPPET study, the first randomized controlled trial to compare the immunogenicity of plasma-derived FVIII (pdFVIII)/von Willebrand factor (VWF) and recombinant-DNA-derived FVIII (rFVIII), demonstrated higher inhibitor rates in previously untreated patients (PUPs) treated with rFVIII than in PUPs treated with pdFVIII/VWF.Objective: To quantify the economic impact of treating PUPs with pdFVIII/VWF vs rFVIII.Methods: An Excel-based clinical and economic model was developed from a US healthcare payer perspective and run over a 5-year period. The analysis utilized a cohort approach to model patient treatment and outcomes over a monthly cycle to quantify differences in costs of FVIII, bypassing agents, and hospitalizations for serious bleeds. Rates of high-titer inhibitor development were obtained from the SIPPET study. Patients developing high-titer inhibitors were treated with immune tolerance induction (ITI). Patients who developed low-titer inhibitors and those who did not develop inhibitors continued their usual FVIII treatment. Patients who were successfully treated with ITI returned to FVIII treatment, while unsuccessfully treated patients received bypassing agents. Total costs per treated patient were estimated and a one-way sensitivity analysis was conducted to quantify the impact of parameter uncertainty on the model outcomes.Results: Total cumulative costs per patient over 5 years were $834,621 for pdFVIII/VWF patients and $1,237,163 for rFVIII patients, representing a total saving of $402,542 per patient over the 5-year period, for an average annual saving of $80,508 per patient.Conclusions: Based on data from the SIPPET study, this analysis found that initiating FVIII treatment in severe hemophilia A PUPs with pdFVIII/VWF has the potential to offer substantial cost savings to healthcare payers, amounting to a one-third reduction in costs. 相似文献
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Shark-diving tourism provides important economic benefits to the Maldives. We examine the link between shark conservation actions and economic returns from diving tourism. A combined travel cost and contingent behaviour approach is used to estimate the dive trip demand under different management scenarios. Our results show that increasing shark populations could increase dive-trip demand by 15%, raising dive tourists’ welfare by US$58 million annually. This could result in annual economic benefits for the dive-tourism industry of >US$6 million. Conversely, in scenarios where shark populations decline, where dive tourists observe illegal fishing, or if dive operators lack engagement in shark conservation, dive trip demand could decrease by up to 56%. This decline causes economic losses of more than US$24 million annually to the dive tourism industry. These results highlight the dependence of the shark-diving industry on the creation and enforcement of appropriate management regimes for shark conservation. 相似文献
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论文从热电联产企业的特征入手,通过对精益成本管理理论的研究,总结出热电联产企业精益成本管理的评价指标,并通过对指标的分析总结出精益成本管理在热电联产企业实际应用中的管理对策。 相似文献
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郭婧华 《中小企业管理与科技》2021,(8)
建筑企业为了进一步扩大盈利空间,在项目运行期间于造价管理工作中引入集成管理理论,采用全过程造价咨询管控方式,提升项目成本管控能力。论文考虑到造价管理对建筑企业的重要性,着重介绍集成管理理论在全过程造价咨询领域的应用方式。 相似文献
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徐阳洋 《中小企业管理与科技》2021,(2)
为实现工程造价精细化管理目标,需要各个环节的相互配合来达到资源优化配置。BIM技术依托虚拟建模技术,实现了对工程项目的数字化建造管理。实践证明,将BIM技术融入项目工程造价管理体系中,有助于提升工程造价管理的整体质量。论文立足工程造价精细化管理的内涵,剖析了BIM技术在工程造价精细化管理中的应用价值,并提出了BIM技术在工程造价精细化管理中的具体应用策略。 相似文献
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