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Entrepreneurs need to act under conditions of uncertainty and resource constraints to bring new, often-unrecognizable products to market and convince an unknown set of stakeholders to support their endeavours. The type of action entrepreneurs take to navigate uncertain entrepreneurial contexts is underspecified. We analysed 48 interviews with entrepreneurs to inductively identify an action-oriented construct we labelled as entrepreneurial hustle – an entrepreneur’s urgent, unorthodox actions that are intended to be useful in addressing immediate challenges and opportunities under conditions of uncertainty. In a follow-up study, we use an experimental vignette approach to assess the impact of an entrepreneur’s hustle on venture stakeholders. Findings suggest that entrepreneurial hustle positively influences stakeholder perceptions of the entrepreneur’s leadership effectiveness and a venture’s legitimacy, mediated by perceptions of the entrepreneur’s ability-based trustworthiness. We conclude that entrepreneurial hustle is a fundamental behaviour that enables entrepreneurs to enrol new venture stakeholders and lead their entrepreneurial efforts.  相似文献   
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Consider m observers each classifying n objects into one of two disjoint categories. The problem of measuring agreement among m observers is discussed. A new approach, based on a specific parametric model, is recommended. The approach is applied to data on agreement in judging biopsy slides.  相似文献   
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Incentive packages are popular tools for economic development. However, development projects are often considered in isolation without an analysis of opportunity costs. In this study, we use an intuitive framework for comparing projects and weigh alternate projects against North Carolina’s film incentive programme. The results indicate that there are substantial differences in the economic impact of the projects we consider in this study. Our results suggest that policy decisions by governments and economic development officials should weigh a potential project against alternative uses in order to optimize the use of incentives.  相似文献   
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Abstract. Estimation of success rates in the two–period change–over clinical trial with binary responses is considered under a mixed model for the design.  相似文献   
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Abstract. Several generalizations of the signed–rank test for testing of equality of p treatments in p related samples against general and trend alternative are discussed. A new generalized test is described and exemplified.  相似文献   
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ABSTRACT

The Dualistic Model of Passion (DMP) is an emerging framework in social psychology that assesses individuals’ passion for an activity. Although a passion parallels the definition for a serious leisure activity, the DMP further differentiates between a harmonious (HP) versus an obsessive (OP) passion, which are associated with adaptive versus maladaptive outcomes, respectively. Building on recent research in the area of mindfulness and the growing interest in problem video gaming, the present study explores the effect of dispositional mindfulness on reports of HP and OP. An online sample of adult video game users (N = 1,124; 68.95% male) completed assessments of their passion for video gaming as well as their dispositional mindfulness. Results revealed a negative association between dispositional mindfulness and OP for video gaming, but no association between dispositional mindfulness and HP for video gaming. Further, a moderation effect was found such that high dispositional mindfulness appears to protect against internalizing an OP for video gaming. Finally, results from a latent profile generally supported the role dispositional mindfulness plays in reducing the severity of OP for video gaming. The implications for theory and positive video game engagement are discussed.  相似文献   
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Conclusion Two independent tests with a total of 36 large and medium-sized non-southern cities have demonstrated support for a political explanation of the major riots of the 1960s. It is argued that politically interested and motivated segments of the black community were disaffected because of the failure of government to respond to their demands. Their participation turned minor disorders into major uprisings. An alternative hypothesis, that public policy response generates increased expectations and ultimately greater violence, has been rejected. However, the findings rest upon the riot experience of a small number of cities in the 1960s. It seems very unlikely that the public policies of these cities would have much impact on the expectations of their black citizens and thus the rationale of the alternative hypothesis is undermined. The public policies of other governments, at other times, might have more influence on the expectations of their citizens. Additional research would be required to identify circumstances under which public policy response might lead to increased expectations, disaffection, and ultimately greater violence.  相似文献   
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Aims: To determine the cost-effectiveness of treatment sequences of biologic disease-modifying anti-rheumatic drugs or Janus kinase/STAT pathway inhibitors (collectively referred to as bDMARDs) vs conventional DMARDs (cDMARDs) from the US societal perspective for treatment of patients with moderately to severely active rheumatoid arthritis (RA) with inadequate responses to cDMARDs.

Materials and methods: An individual patient simulation model was developed that assesses the impact of treatments on disease based on clinical trial data and real-world evidence. Treatment strategies included sequences starting with etanercept, adalimumab, certolizumab, or abatacept. Each of these treatment strategies was compared with cDMARDs. Incremental cost, incremental quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs) were calculated for each treatment sequence relative to cDMARDs. The cost-effectiveness of each strategy was determined using a US willingness-to-pay (WTP) threshold of $150,000/QALY.

Results: For the base-case scenario, bDMARD treatment sequences were associated with greater treatment benefit (i.e. more QALYs), lower lost productivity costs, and greater treatment-related costs than cDMARDs. The expected ICERs for bDMARD sequences ranged from ~$126,000 to $140,000 per QALY gained, which is below the US-specific WTP. Alternative scenarios examining the effects of homogeneous patients, dose increases, increased costs of hospitalization for severely physically impaired patients, and a lower baseline Health Assessment Questionnaire (HAQ) Disability Index score resulted in similar ICERs.

Conclusions: bDMARD treatment sequences are cost-effective from a US societal perspective.  相似文献   

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