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1.
This paper is concerned with the effects of international trade restriction through quotas. It is shown that a casual relationship exists between the fraction of licences distributed domestically, the terms of trade, and the domestic relative price of the importable.  相似文献   
2.
    
Objective: Philadelphia chromosome negative [Ph(?)] relapsed or refractory (R/R) B-precursor acute lymphoblastic leukemia (ALL) is an extremely rare condition requiring intensive treatment. This retrospective chart review aimed to quantify hospitalizations and reimbursement in this patient population in France.

Methods: Patients aged ≥18 years and with at least one hospitalization for Ph(?) R/R B-precursor ALL were included in the study. They were relapsed with first remission lasting <12 months, relapsed after first salvage therapy, relapsed any time after hematopoietic stem cell transplant (HSCT), or were refractory to initial or salvage therapy. Data were collected from the index date (first diagnosis of R/R ALL) until death or loss to follow-up. The chemotherapy period was defined as the first chemotherapy date after the index date to the earliest of death, loss to follow-up, last chemotherapy dose plus 30 days, or initiation of HSCT. The primary outcome was the percentage of time hospitalized during the chemotherapy period.

Results: Thirty-three patients were included, with a mean age of 49 years. The mean proportion of time spent in the hospital during the chemotherapy period was 46% (95% CI =34–57%). Patients had a mean of 2.2 (SD =1.5) inpatient hospitalizations and the mean length of stay per hospitalization was 16.8 (SD =14.8) days. During the chemotherapy period, the mean amount reimbursed per hospitalization was €31 067 (SD = €4850) and the total hospitalization reimbursement per patient was €68 344. From the index date to death, excluding HSCT, the total reimbursement per patient was €108 873.

Limitations: The sample size was small, although this was expected given the rarity of the patient population.

Conclusions: Adults with Ph(?) R/R B-precursor ALL had repeated and prolonged hospitalizations during salvage chemotherapy. Approximately half the follow-up period was spent in the hospital, and this time was associated with high economic burden in France.  相似文献   
3.
    
Some recent studies have benefited from advances in time series econometrics in order to evaluate price transmission mechanisms along the marketing chain. Due to the length of time series, structural changes may affect the evaluation of price–cost margins. In the case of the fresh salmon trade between Norway and France, the gross margin between producers and retailers has changed in level between January 1988 and December 1999. This article accurately identifies the date of a structural change using a range of recent ADF testing procedures (Gregory–Hansen tests, forward and backward recursive tests), before looking for the causes of the change through a survey. Two major factors can be identified: the product form and the marketing channel. Interestingly, both the increasing level of processing and the development of supermarket chains have resulted in a new role for the intermediaries, shifting from mere commercial intermediation to sub‐contracting for the big retailers.  相似文献   
4.
Some research questions involve several dimensions. The most rewarding approach may be switching (under control) between the diverse methods and databases involved. Having recourse to different dimensions that form a system produces wider results but also opens up new questions. A survey on the evolutions of social networks and life transitions of young people draws an original design including contextual names generators, questionnaires and interviews in a longitudinal perspective. Young people interviewed every 3 years on 4 survey waves produced a total of 287 interviews and networks and a global amount of 10,804 relationships informed. This article aims to highlight this specific potential of integrating qualitative, qantitative and structural dimensions in an iterative process of data construction and analysis. The methodological argument is empirically illustrated with a focus on the thematic of influence of the network upon life orientations. It shows influence comes mainly from strong central ties but also from some peripheral isolated mates. The structural evolution reveals a general trend of dissociation of their ties the ones from the others when people are entering adult life, which makes influence from the network become more and more diversified.  相似文献   
5.
    
This article explores the organisational and legal context in which parties involved in claims relating to sexual harassment operate, and presents an analysis of the population of sexual harassment cases heard by Employment Tribunals between 1995 and 2005.  相似文献   
6.
Collaborative, team-based research is now the most significant mode of activity in the global scientific community. Anecdotal and statistical evidence shows moreover that collaboration in scientific research is increasingly global in nature. That is, the groups of researchers who are involved in scientific progress often span one or more nations in origin, location and/or sponsorship. Another significant trend in recent cases of scientific collaboration is the increase in cross-sectoral cooperation, where researchers in a group are employed by government, private industry, and/or academic and other non-profit institutions.
In this paper, we review the scale, scope and intensity of cross-national, cross-sectoral research collaboration through the analysis of historical data on co-authorship of scientific publications. The first part of the paper reviews existing literature on the analysis of co-authorship data, and discusses the limitations of this form of analysis and typical strategies to mitigate those limitations. The second part of the paper describes a preliminary study of cross-national, cross-sectoral scientific collaborations covering the years 1988 through 1997, where we examined the scale (volume of co-authored papers), intensity (co-authored papers versus other kinds of co-authorship), and scope (patterns in co-authorship) for cross-national, cross-sectoral collaborations. The conclusion of the paper discusses significant trends and patterns derived from this study, and their implications for further research into these types of collaborations.  相似文献   
7.
In this paper we propose a subsampling estimator for the distribution of statistics diverging at either known or unknown rates when the underlying time series is strictly stationary and strong mixing. Based on our results we provide a detailed discussion of how to estimate extreme order statistics with dependent data and present two applications to assessing financial market risk. Our method performs well in estimating Value at Risk and provides a superior alternative to Hill's estimator in operationalizing Safety First portfolio selection.  相似文献   
8.
    
We study contracts designed to remunerate a farmer for the production of an ecosystem service with the payment dependent on the results of the farmer’s actions and on weather conditions. Two contracts are proposed: the first takes into account both the results of the farmer’s actions and a weather variable that reflects the actual atmospheric conditions during the life of the contract; the second bases the payment on the results alone incorporating only the average effect of weather. Social welfare is optimal when both the results and the specific atmospheric conditions are taken into account; however, this type of contract may be less acceptable to the farmer due to his perception of the level of risk involved.We thank two referees for valuable comments.  相似文献   
9.
The purpose of this study is to examine how credit rating agencies’ decisions impact the stock market using a systematic and quantitative review of existing empirical studies. Specifically, we employ a meta‐regression analysis (MRA) to investigate the extent and nature of the effect of rating agencies’ decisions on the stock market. We survey 62 studies published between 1978 and 2015. Our first finding is that the cumulative average abnormal returns calculated from this empirical literature are affected by publication bias. After controlling for publication bias, the main findings of our meta‐analysis indicate that negative rating decisions cause statistically significant negative abnormal returns. This evidence suggests an informational effect. Our results also indicate that positive rating decisions do not have a significant effect. Finally, the MRA results reveal the importance of several factors related to primary study design, as well as to the nature of the data.  相似文献   
10.
    
Geoscientists are faced with a number of complexities that represent obstacles to the development of realistic simulation of deep earth processes. Realistic 4D thermo-mechanical simulation using software packages like Underworld and Gale, when combined appropriately with geoscientific expertise, can lead to novel insights into the deformation of geological structures at a wide range of time and spatial scales. The challenge for end-user geoscientists lies in applying their knowledge within the framework of the software’s input specification, including initial, internal, and boundary conditions and output visualization parameters. We have built a Graphical User Interface (GUI) to remove many of the difficulties related to editing the Extensible Markup Language (XML) encoded input files of Underworld/Gale geomodels and therefore, to greatly broaden the user base of these software packages. By helping Underworld/Gale to meet a large audience, we provide a tool to the geoscience community that helps to move from untested conceptual models to physically valid, properly scaled modelling. Furthermore, the UnderworldGUI offers a mechanism for storing and retrieving experimental models in a centralised database, thus providing the geoscience community with a means to share the outcomes of its experimental research. Further details of the UnderworldGUI are available at the web site http://www.wiki.vislab.usyd.edu.au/moinwiki/UnderworldGUI.  相似文献   
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