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Aims: Depression is the most frequent comorbidity reported among patients with rheumatoid arthritis (RA). Comorbid depression negatively impacts RA patients’ health-related quality-of-life, physical function, mental function, mortality, and experience of pain and symptom severity. The objective of this study was to assess healthcare utilization, expenditures, and work productivity among patients with RA with or without depression.Materials and methods: Data from adult patients who had at least two visits each related to RA and depression over a 1-year period were extracted from the Truven Health MarketScan research databases. Outcomes comprised healthcare resource utilization, work productivity loss, and direct healthcare costs comparing patients with RA with depression (n?=?3,478) vs patients with RA without depression (n?=?43,222).Results: Patients with RA and depression had a significantly greater relative risk of hospitalization and number of all-cause and RA-related hospitalizations, utilization of emergency services, days spent in the hospital, physician visits, and RA-related surgeries compared with RA patients without depression. Patients with RA and depression had a higher risk of and experienced more events and days of short-term disability compared with patients without depression. The incremental adjusted annual all-cause and RA-related direct costs were $8,488 (95% CI = $6,793–$10,223) and $578 (95% CI = –$98–$1,243), respectively, when comparing patients with RA and depression vs RA only.Limitations: The current analysis is subject to the known limitations of retrospective studies based on administrative claims data.Conclusions: This study suggested increased healthcare utilization, work productivity loss, and economic burden among RA patients due to comorbid depression. These findings emphasize the importance of managing depression and including depression as a factor when devising treatment algorithms for patients with RA. 相似文献
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企业创新是国家经济可持续增长的关键,受到管理层意愿的影响,因而需要对内部经营者的权力进行制衡。以2010-2018年我国A股上市公司为研究样本,实证检验管理层权力制衡强度对企业创新投资的影响,以及不同债务约束情境下高商业信用配置、高负债水平的调节效应,此外,还考察了产权性质的差异化影响。研究表明,管理层权力制衡强度越大,企业创新投资水平越高;高商业信用强化了该促进作用,而高负债水平弱化了该促进作用。进一步研究发现,管理层权力制衡强度与企业创新投资的关系在民企中更显著;国企能够更好地获得和运用商业信用,使其高商业信用对该关系的强化效应更显著;民企具有更强的债务约束,其高负债水平对该关系的弱化效应更明显。 相似文献
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Peter C. Young 《International Journal of Forecasting》2018,34(2):314-335
The main objective of this paper it to model the dynamic relationship between global averaged measures of Total Radiative Forcing (RTF) and surface temperature, measured by the Global Temperature Anomaly (GTA), and then use this model to forecast the GTA. The analysis utilizes the Data-Based Mechanistic (DBM) approach to the modelling and forecasting where, in this application, the unobserved component model includes a novel hybrid Box-Jenkins stochastic model in which the relationship between RTF and GTA is based on a continuous time transfer function (differential equation) model. This model then provides the basis for short term, inter-annual to decadal, forecasting of the GTA, using a transfer function form of the Kalman Filter, which produces a good prediction of the ‘pause’ or ‘levelling’ in the temperature rise over the period 2000 to 2011. This derives in part from the effects of a quasi-periodic component that is modelled and forecast by a Dynamic Harmonic Regression (DHR) relationship and is shown to be correlated with the Atlantic Multidecadal Oscillation (AMO) index. 相似文献
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We present a longitudinal qualitative case study to elaborate on how a social venture forms reference points for social performance. Although organizations increasingly use various social performance targets to direct their operations, the scholarly knowledge on social performance reference points remains limited. We make use of the prior accounting literature and draw on the idea of compromising accounts to discuss how provisional and performative metrics can have a significant role in how organizations develop new ways to evaluate their social performance. Given that the social performance reference point criteria are ambiguous and the corresponding referents malleable, performative accounts are helpful as they can intervene in the organizational life by making particular things visible, providing space for interpretations, and facilitating discussion, thus creating temporary settlements and enabling opportunities for productive compromises between different organizational groups and evaluative principles. The recursive feedback loops between reference point referents, criteria and accounting artefacts help the organization to make sense of its own social performance and interpret the associated performance feedback, and thereby provide ground for organizational decisions on further action. Moreover, we discuss how imperfect accounts can be useful for social businesses in their pursuit of developing their activities and achieving social impact. 相似文献
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Aaron H. Anglin Jeremy C. Short Will Drover Regan M. Stevenson Aaron F. McKenny Thomas H. Allison 《Journal of Business Venturing》2018,33(4):470-492
We extend the entrepreneurship literature to include positive psychological capital — an individual or organization's level of psychological resources consisting of hope, optimism, resilience, and confidence — as a salient signal in crowdfunding. We draw from the costless signaling literature to argue that positive psychological capital language usage enhances crowdfunding performance. We examine 1726 crowdfunding campaigns from Kickstarter, finding that entrepreneurs conveying positive psychological capital experience superior fundraising performance. Human capital moderates this relationship while social capital does not, suggesting that costly signals may, at times, enhance the influence of costless signals. Post hoc analyses suggest findings generalize across crowdfunding types, but not to IPOs. 相似文献
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Stephen G. Dimmock William C. Gerken Zoran Ivković Scott J. Weisbenner 《Journal of Financial Economics》2018,127(1):113-135
Differences in accrued gains and investors’ tax-sensitivity induce variation in a capital gains lock-in effect across mutual funds even for the same stock at the same time. Exploiting this variation, we show this effect influences funds’ governance decisions: higher capital gains decrease the likelihood a fund exits prior to contentious votes and increase the likelihood a fund votes against management. Consistent with tax motivation, these findings are concentrated among funds with tax-sensitive investors. Further, high aggregate capital gains across funds holding a stock predict a higher likelihood management loses a vote and a lower likelihood a contentious vote is proposed. 相似文献
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AbstractTraditional warranty analysis focuses on the reliability of a product and offers warranty designs that compensate a consumer if the item fails. We introduce the concept of a performance-based warranty (PBW) that guarantees that a product will operate at or above some baseline level of performance, such as a minimum energy efficiency for an appliance. We illustrate how consumer behavior can change in the presence of a PBW and define the parameters for which a manufacturer may increase revenue. Finally, we present an algorithm to solve for the optimal PBW design given a consumer’s belief about the expected performance of the product. 相似文献
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