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Elias J. Jabbour Martin F. Mendiola Melissa Lingohr-Smith Jay Lin Dinara Makenbaeva 《Journal of medical economics》2013,16(11):1113-1118
AbstractObjective: To develop an economic model to evaluate changes in healthcare costs driven by restricting usage of branded tyrosine kinase inhibitors (TKIs) through substitution with generic imatinib among chronic myeloid leukemia (CML) patients in a typical Oncology Care Model (OCM) practice, and examine the impact on Performance-Based Payment (PBP) eligibility.Methods: An Excel-based economic model of an OCM practice with 1,000 cancer patients during a 6-month episode of care was developed. Cancer types and proportions of patients treated in the practice were estimated from an OCM report. All-cause healthcare costs were obtained from published literature. It was assumed that if a practice restricts usage of branded TKIs for newly-diagnosed CML patients, 80% of the market share of branded imatinib and 50% of the market shares of 2nd-gen TKIs would shift to generic imatinib. Among established TKI-treated patients, it was assumed that 80% of the market share of branded imatinib and no patients treated with 2nd-gen TKIs would shift to the generic.Results: Four CML patients were estimated for a 1,000-cancer patient OCM practice with a total baseline healthcare cost of $51,345,812 during a 6-month episode. If the practice restricts usage of branded TKIs, the shift from 2nd-gen TKIs to generic imatinib would reduce costs by $12,970, while shifting from branded to generic imatinib lowers costs by $25,250 during a 6-month episode. Minimum reductions of $3,013,832 in a one-sided risk model and $2,372,010 in a two-sided risk model are required for PBP eligibility; the shift from 2nd-gen TKIs to generic imatinib would account for 0.4% and 0.5% of the savings required for a PBP, respectively.Conclusions: This analysis indicates that the potential cost reduction associated with restricting branded TKI usage among CML patients in an OCM setting will represent only a small proportion of the cost reduction needed for PBP eligibility. 相似文献
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Red Christine Lovely Teng-Calleja Mendiola 《Employee Responsibilities and Rights Journal》2021,33(4):337-357
Employee Responsibilities and Rights Journal - This study examined the effect of legal compliance in the context of labor laws, and the role of organizational justice in mediating its relationship... 相似文献
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Alfred Presbitero Mendiola Teng-Calleja 《Journal of Human Resources in Hospitality & Tourism》2017,16(4):401-421
ABSTRACTDrawing from self-regulation and goal-regulation theories, this study focuses on employee proactivity in the context of a hotel that is undergoing change and development. Two hundred twenty eight employees from a hotel undergoing restructuring in Australia took part in this study. A survey instrument was developed and the data obtained from the survey were analyzed. Results show that employee proactive envisioning, employee proactive planning, and employee proactive enacting are positively and significantly interrelated. In addition, results show that organizational climate for innovation and leader vision are positively and significantly related to employee proactive envisioning and serve as situational correlates of employee proactivity. Implications for human resource management, particularly in the hotel industry, are discussed. 相似文献
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