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Aims: Depression is the most frequent comorbidity reported among patients with rheumatoid arthritis (RA). Comorbid depression negatively impacts RA patients’ health-related quality-of-life, physical function, mental function, mortality, and experience of pain and symptom severity. The objective of this study was to assess healthcare utilization, expenditures, and work productivity among patients with RA with or without depression.

Materials and methods: Data from adult patients who had at least two visits each related to RA and depression over a 1-year period were extracted from the Truven Health MarketScan research databases. Outcomes comprised healthcare resource utilization, work productivity loss, and direct healthcare costs comparing patients with RA with depression (n?=?3,478) vs patients with RA without depression (n?=?43,222).

Results: Patients with RA and depression had a significantly greater relative risk of hospitalization and number of all-cause and RA-related hospitalizations, utilization of emergency services, days spent in the hospital, physician visits, and RA-related surgeries compared with RA patients without depression. Patients with RA and depression had a higher risk of and experienced more events and days of short-term disability compared with patients without depression. The incremental adjusted annual all-cause and RA-related direct costs were $8,488 (95% CI = $6,793–$10,223) and $578 (95% CI = –$98–$1,243), respectively, when comparing patients with RA and depression vs RA only.

Limitations: The current analysis is subject to the known limitations of retrospective studies based on administrative claims data.

Conclusions: This study suggested increased healthcare utilization, work productivity loss, and economic burden among RA patients due to comorbid depression. These findings emphasize the importance of managing depression and including depression as a factor when devising treatment algorithms for patients with RA.  相似文献   
3.
军民融合产业园区高质量发展对于推进军民深度融合、在全国形成可复制可推广经验具有重要意义。军民融合协同创新通过促进新知识涌现、推进新产业集聚发展,最终汇聚经济发展新动能,驱动园区高质量发展。在提出军民融合协同创新驱动园区高质量发展的机理与组织框架基础上,将发展模式归纳为以分享经济为背景的资源共享模式、以新型研发机构为核心的第三方模式、以产业联盟为核心的产业链拓展模式和以交易平台为核心的“PPP”模式,最后提出相关对策建议。  相似文献   
4.
企业创新是国家经济可持续增长的关键,受到管理层意愿的影响,因而需要对内部经营者的权力进行制衡。以2010-2018年我国A股上市公司为研究样本,实证检验管理层权力制衡强度对企业创新投资的影响,以及不同债务约束情境下高商业信用配置、高负债水平的调节效应,此外,还考察了产权性质的差异化影响。研究表明,管理层权力制衡强度越大,企业创新投资水平越高;高商业信用强化了该促进作用,而高负债水平弱化了该促进作用。进一步研究发现,管理层权力制衡强度与企业创新投资的关系在民企中更显著;国企能够更好地获得和运用商业信用,使其高商业信用对该关系的强化效应更显著;民企具有更强的债务约束,其高负债水平对该关系的弱化效应更明显。  相似文献   
5.
目前我国土地闲置现象触目惊心,造成实质的资源浪费和损失。从性质上来分析,土地闲置也属于土地市场失灵,需要由行使公共职能的政府给予矫正。在目前的各种矫正措施中,有偿收回是一种较为可行的措施。有偿收回,既可提高闲置土地的处置效率,使土地效益尽早实现,又能降低博弈和交易成本,有利于维护当地的投资环境、更有利于稳定土地需求预期、端正投资动机,对地方的财政收入及经济社会平稳健康发展都具有正面价值。  相似文献   
6.
Motivated by the European sovereign debt crisis, we propose a hybrid sovereign default model that combines an accessible part taking into account the evolution of the sovereign solvency and the impact of critical political events, and a totally inaccessible part for the idiosyncratic credit risk. We obtain closed‐form formulas for the probability that the default occurs at critical political dates in a Markovian setting. Moreover, we introduce a generalized density framework for the hybrid default time and deduce the compensator process of default. Finally, we apply the hybrid model and the generalized density to the valuation of sovereign bonds and explain the significant jumps in long‐term government bond yields during the sovereign crisis.  相似文献   
7.
ABSTRACT

This research introduces online travel photos published on social media platforms as a complementary data resource to examine the behavior and experience of museum visitors. The practical value of online travel photos is demonstrated through a case study of popular Hong Kong museums, particularly by using the photo content and metadata available from the Flickr platform. The proposed approach is a generic method for understanding museum visitor behavior and preferences, and supports museum practitioners in developing improved products for visitors. The case study findings are particularly beneficial for tourism managers, especially those in Hong Kong, in promoting and attracting tourists to visit local museums.  相似文献   
8.
Previous research has shown that virtuous leader behavior in the form of benevolent leadership has considerable impact on employee creativity. However, little is known as to how and under what conditions these constructs are linked. In the current research, we proposed and tested a moderated mediation model positing leader–member exchange (LMX) as a mediator, and employee power-distance orientation as a moderator of this relationship. Two studies were conducted to test our hypothesized model. In Study 1, repeated measured data collected from 284 Chinese employees in an information technology company demonstrated that benevolent leadership had a lagged effect on LMX. In Study 2, analyses of multisource and lagged data from 391 Chinese employees in 42 research and development teams, and their direct supervisors indicated that benevolent leadership was positively related to supervisor-rated employee creativity via LMX. In addition, the relationship between benevolent leadership and LMX was stronger for employees high in power-distance orientation. Theoretical implications of benevolent leadership’s research and practical contributions concerning promoting creativity in organizations where benevolent leaders prevail are also discussed.  相似文献   
9.
深入分析我国“一带一路”沿线地区风险投资时空格局及影响因素,有助于促进创新创业与企业发展、提高区域科技创新水平。运用空间分析方法和空间计量模型,对2003-2018年我国“一带一路”沿线139个城市风险投资的时空分布特征及影响因素进行分析,结果表明:①沿线地区的风险投资发展具有不均衡性,呈现为沿海高、西部低的分异格局;②风险投资的全局自相关系数均为正,呈现出明显的空间集聚特征;③风险投资机构数、国家高新区数量、风险投资退出、政府引导基金发展、财政科技支出对区域风险投资具有显著促进作用,环境污染对风险投资有一定抑制作用。随着ESG投资理念逐渐获得认可,沿线地区可以通过提升绿色发展水平促进风险投资发展。  相似文献   
10.
近年来,中国地方政府债务持续扩张引起政府、社会和学界的高度关注.通过构建一个包含地区增长目标、分税制和地方政府博弈的动态随机一般均衡模型,从税制视角对地方债扩张这一现象加以解释.研究表明,在地方政府追求经济增长的背景下,当前的税收制度扩大了地方政府发生短视或者经济出现不利冲击时政府债务扩张的程度.渠道分析发现,地方政府发生短视时,顺周期的增值税放松了地方财政约束并降低了地方政府债务扩张程度,转移支付降低了地方借贷成本并提高了债务扩张程度;负向生产率冲击发生时,顺周期的税收收入加剧了财政压力并放大了地方政府债务的扩张.此外,地区竞争放大了税制产生作用的强度.由此,可以通过增加财产税等直接税的比重、规范转移支付的获取和促进地区协作等方式限制地方政府债务扩张.  相似文献   
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