新时期学前教育专业实训教育体系建构研究

要达到培养具有良好职业道德的高技能人才的目标,高等职业教育必须高度重视学生实践能力的培养。面对新时期的学前教育专业,完善的专业实训教学体系是培养合格人才的重要保障。     

提高分层注水管柱工作可靠性

通过对胜利油田分层注水工艺现状进行调研,对影响分层注水管柱工作可靠性的因素进行了分析,找出了造成分层注水管柱层段合格率低的主要因素是管柱的结构及井下配套工具的质量及使用性能问题。针对存在的问题,通过分析,提出了提高分层注水管柱工作可靠性的有效途径,并进行了应用试验,对实施情况进行了介绍,验证了提高分层注水管柱工作可靠性的途径。     

On disequilibrium adjustment processes

Here, we study a class of disequilibrium processes defined by differential inequalities, where prices are adjusted according to the agent's short-term demands, in both pure exchange and monetary settings. We establish convergence theorem and accessibility theorem without convexity hypotheses on the utility functions.     

一种基于集合的Web用户会话实时聚类算法

随着互联网的普及和电子商务、个性化推荐技术等的发展,Web使用挖掘成为了数据挖掘的新的研究热点。针对Web用户会话聚类,提出了一种基于序列对集合的用户会话实时聚类方法。对聚类算法进行了分析与比较,给出了时空复杂度,实验比较了BOM算法与BOC算法的效率,并验证了BOC算法的有效性与时效性。     

基于萤火虫算法带时间窗的双向配送调度

针对带时间窗的双向配送调度问题,重新建立新的带多目标的数学模型,提出一种离散型萤火虫算法和编码策略,并重新定义了个体交叉变异移动公式。同时,根据萤火虫编码个体之间的逻辑距离,构建邻域集合,提高局部搜索能力。并引进个体历史最优记忆功能,加快收敛速度。最后利用随机数和求余函数对编码个体进行扰动,防止过早陷入局部极值。通过仿真案例实验验证了算法的有效性。     

基于小波变换的GPS变形监测数据处理方法研究

工程实测变形信号不可避免的受到噪声的污染,为了提取真实的变形信号,要对实测数据进行降噪处理。结合武汉某大桥GPS实测变形数据介绍了小波变换阈值降噪过程,分别采用不同的小波函数和不同阈值模型进行降噪处理。根据信噪比、中误差两种降噪质量评价指标的定量比较,得出用db6小波和heursure阈值在软阈值量化作用下降噪效果较其他小波函数和阈值模型效果好。     

Land transfer in rural China: incentives,influencing factors and income effects

ABSTRACT

Land transfer incentives and their effect on farmers’ income in developing countries have been widely examined in the literate, but little is known about the driving mechanism of rural household income effect during land transfer. To fill in this gap, this paper explains the incentives of land transfer, analyses the influencing factors of farmers’ decision on land transfer, then measures the income effects of land transfer and identifies the main sources of income effects, utilizing open-access data collected through the China Family Panel Studies. The empirical results show that land flow out or in is beneficial to raise farmers’ income, indicating that the income effects have a positive feedback to farmers’ decision on land transfer. Further analyses reveal that land flow-out farmers and land flow-in farmers have different main sources of income growth. Our finding suggest that optimizing the incentive role of China’s existing rural land property system can help orderly flow of rural land resources, which subsequently increases rural household income.     

基于神经网络的粮食物流中心选址决策研究

粮食物流中心建设是一项规模大、投资多、影响巨大的系统工程。选址决策对整个粮食物流系统的优化十分重要。阐述了粮食物流中心选址的原则和影响因素,分析了神经网络用于粮食物流中心选址的优点,构建了基于BP神经网络的粮食物流中心选址决策模型,并用算例说明了该方法的有效性。     

专类公园发展趋势及规划建设应对的思考

专类公园对于提高城市绿地游憩服务质量具有重要 作用。从梳理专类公园的历史发展和现状入手，总结了专类公 园多元化和专业化、层级化和社区化、优质化和精品化的发展 趋势。提出“丰富多元、因城施策、因地制宜、量力而行”的 发展原则，从类型构成、分类配置、分级配置和指标管控等方 面探讨了促进专类公园发展的理念和策略，并从规划、政策、 运营等角度提出了未来的探索方向。     

Economic burden in patients with ALK + non-small cell lung cancer,with or without brain metastases,receiving second-line anaplastic lymphoma kinase (ALK) inhibitors

Abstract

Aims: To describe the real-world economic burden of patients with anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer (NSCLC) treated with post-crizotinib, second-line ALK inhibitor therapy.

Materials and methods: Retrospective analysis using data from US Optum: Clinformatics Data Mart administrative claims database. Adult patients with ALK?+?NSCLC treated with ceritinib or alectinib as second-line ALK inhibitors between 1 January 2011 and 30 September 2017 were included. Healthcare costs and resource utilization for up to 1?year of therapy were calculated on a per-patient-per-month (PPPM) basis and stratified by presence or absence of brain metastases (BM). Multivariate regression analysis was performed to identify factors associated with costs. Top ten cost drivers of non-inpatient procedure costs were recorded.

Results: One hundred and twelve patients received second-line ALK inhibitors. Total mean PPPM healthcare costs were $23,984 for all patients receiving up to 1?year of post-crizotinib, second-line ALK inhibitor therapy. Total mean PPPM costs for patients with BM on or prior to post-crizotinib, second-line ALK inhibitor therapy were 1.37-times as high as those for patients without BM (p?=?0.0406). Mean PPPM outpatient visits and inpatient hospitalization stays were higher for patients with BM versus no BM. The main cost drivers for non-inpatient procedures were radiation therapy, medications, and diagnostic radiology.

Limitations: Analyses did not include newer ALK-directed therapies. BM development after the index date (defined as the date of the first claim for a second-line ALK inhibitor) may have been misclassified as non-BM. Findings may not be generalizable to patients with no health insurance coverage.

Conclusions: Treatment of patients with ALK?+?NSCLC with ceritinib or alectinib as post-crizotinib, second-line ALK inhibitor therapy represents a high economic burden. Healthcare costs and resource utilization were significantly higher for patients with ALK?+?NSCLC with BM versus no BM.