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Aims: Depression is the most frequent comorbidity reported among patients with rheumatoid arthritis (RA). Comorbid depression negatively impacts RA patients’ health-related quality-of-life, physical function, mental function, mortality, and experience of pain and symptom severity. The objective of this study was to assess healthcare utilization, expenditures, and work productivity among patients with RA with or without depression.

Materials and methods: Data from adult patients who had at least two visits each related to RA and depression over a 1-year period were extracted from the Truven Health MarketScan research databases. Outcomes comprised healthcare resource utilization, work productivity loss, and direct healthcare costs comparing patients with RA with depression (n?=?3,478) vs patients with RA without depression (n?=?43,222).

Results: Patients with RA and depression had a significantly greater relative risk of hospitalization and number of all-cause and RA-related hospitalizations, utilization of emergency services, days spent in the hospital, physician visits, and RA-related surgeries compared with RA patients without depression. Patients with RA and depression had a higher risk of and experienced more events and days of short-term disability compared with patients without depression. The incremental adjusted annual all-cause and RA-related direct costs were $8,488 (95% CI = $6,793–$10,223) and $578 (95% CI = –$98–$1,243), respectively, when comparing patients with RA and depression vs RA only.

Limitations: The current analysis is subject to the known limitations of retrospective studies based on administrative claims data.

Conclusions: This study suggested increased healthcare utilization, work productivity loss, and economic burden among RA patients due to comorbid depression. These findings emphasize the importance of managing depression and including depression as a factor when devising treatment algorithms for patients with RA.  相似文献   
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军民融合产业园区高质量发展对于推进军民深度融合、在全国形成可复制可推广经验具有重要意义。军民融合协同创新通过促进新知识涌现、推进新产业集聚发展,最终汇聚经济发展新动能,驱动园区高质量发展。在提出军民融合协同创新驱动园区高质量发展的机理与组织框架基础上,将发展模式归纳为以分享经济为背景的资源共享模式、以新型研发机构为核心的第三方模式、以产业联盟为核心的产业链拓展模式和以交易平台为核心的“PPP”模式,最后提出相关对策建议。  相似文献   
4.
企业创新是国家经济可持续增长的关键,受到管理层意愿的影响,因而需要对内部经营者的权力进行制衡。以2010-2018年我国A股上市公司为研究样本,实证检验管理层权力制衡强度对企业创新投资的影响,以及不同债务约束情境下高商业信用配置、高负债水平的调节效应,此外,还考察了产权性质的差异化影响。研究表明,管理层权力制衡强度越大,企业创新投资水平越高;高商业信用强化了该促进作用,而高负债水平弱化了该促进作用。进一步研究发现,管理层权力制衡强度与企业创新投资的关系在民企中更显著;国企能够更好地获得和运用商业信用,使其高商业信用对该关系的强化效应更显著;民企具有更强的债务约束,其高负债水平对该关系的弱化效应更明显。  相似文献   
5.
Objective: This study was to determine if calcium fortification yields a higher price per serving in grocery store products. Researchers compared store brand to national brand grocery products in relation to cost in order to examine if calcium values were similar between store brand and national brand products. Methods: A total of 112 store brand and 211 national brand grocery products were collected from three low (national chain store), middle and high priced (Virginia and North Carolina regional store) grocery venues. Products were compared using price and calcium percentage per serving. ANOVA was used to determine between store brand and national brand for price per serving and calcium content, and between grocery venues. Results: National brand fortified products had a significantly lower mean price per serving when compared to national brand non-fortified products (p = 0.0002). There was no statistical difference between store brand fortified and non-fortified products (p = 0.9256). Low priced store brand products had the lowest mean price per serving ($0.34 ±0.24). Conclusions: This study found store brand products have similar calcium content as national brand products. Product cost was lower at low priced store compared to middle and high priced stores.  相似文献   
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Motivated by the European sovereign debt crisis, we propose a hybrid sovereign default model that combines an accessible part taking into account the evolution of the sovereign solvency and the impact of critical political events, and a totally inaccessible part for the idiosyncratic credit risk. We obtain closed‐form formulas for the probability that the default occurs at critical political dates in a Markovian setting. Moreover, we introduce a generalized density framework for the hybrid default time and deduce the compensator process of default. Finally, we apply the hybrid model and the generalized density to the valuation of sovereign bonds and explain the significant jumps in long‐term government bond yields during the sovereign crisis.  相似文献   
8.
ABSTRACT

This research introduces online travel photos published on social media platforms as a complementary data resource to examine the behavior and experience of museum visitors. The practical value of online travel photos is demonstrated through a case study of popular Hong Kong museums, particularly by using the photo content and metadata available from the Flickr platform. The proposed approach is a generic method for understanding museum visitor behavior and preferences, and supports museum practitioners in developing improved products for visitors. The case study findings are particularly beneficial for tourism managers, especially those in Hong Kong, in promoting and attracting tourists to visit local museums.  相似文献   
9.
吴传琦  张琪 《南方经济》2021,40(4):18-36
从市场经济体制的建立到经济社会高质量发展,我国不同部门市场化程度有所差异,劳动供给的部门异质性随之体现。基于中国劳动力动态调查数据,结合汉森门槛回归模型和劳动供给模型,依托部门市场化程度的差异性,文章探讨了工资对劳动力个人供给的非线性影响及其部门异质性。主要得出以下研究结论:第一,我国市场部门与公共部门劳动力的个人劳动供给有所差异。第二,工资与个人劳动供给呈现非线性关系并且存在部门异质性。实证分析结果显示,工资对个人劳动供给的影响存在三个"突变点",工资门槛均使得工资"激励效应"加强并呈现逐步增加的趋势。第三,劳动供给的工资门槛存在性别、城乡和行业异质性。第四,随着年龄增长、人力资本积累,个人劳动时间供给趋于降低,签署书面劳工合同使得市场部门劳动力工作时间显著增加,而政治面貌显著影响公共部门劳动供给。总体来看,无论是市场部门还是公共部门,我国劳动力个人供给曲线均未"向后弯曲",国民经济高质量发展、改善收入分配格局、提升居民幸福感等议题需持续关注。  相似文献   
10.
The purpose of this study is to elaborate the structural relationships among the experiential quality dimensions, experiential trust, emotional attachment, experiential image, switching experience, experiential satisfaction, and experiential loyalty from the green perspective. The study findings are based on structural equation modeling (SEM) analysis of a convenience sample of 560 customers at one green restaurant in Taipei City, Taiwan. The findings show that investing resources in an increase in the experiential quality dimensions and a decrease in green switching experience is useful to enhance green experiential trust, green emotional attachment, green experiential image, green experiential satisfaction, and green experiential loyalty.  相似文献   
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