Assessing the needs of assisted reproductive technology users of an online bulletin board

Consumers who are infertile and decide to use assisted reproductive technologies undergo lengthy, expensive and potentially risky medical procedures in their quest for a pregnancy and a live birth. In this research we use a consumer model of decision making to analyse the process. We review information available to consumers and we assess use of an online bulletin board which gives consumers social support and medical information during the process. We conclude with the needs for consumer education and protection.     

循证医学在治疗多囊卵巢综合征中的应用

采用循证治疗的方法为1例已婚未育PCOS患者制定合理的治疗方案,有效提高了治疗疗效和妊娠率。     

A cost-effectiveness analysis comparing the originator follitropin alfa to its biosimilars in patients undergoing a medically assisted reproduction program from a French perspective

Objective: To assess the cost-effectiveness (CE) of the originator follitropin-α (Gonal-F) in patients undergoing a medically assisted reproduction (MAR) program in comparison to its biosimilars Bemfola and Ovaleap in a French context.

Methods: A CE model was developed for France with a National Health Service (NHS) perspective. Clinical, safety, and dosage data were derived from pivotal clinical trials that compared Gonal-F to Ovaleap and Bemfola. Costs pertaining to drugs, hospitalizations, specialist visits, and examinations were retrieved from the French Programme de Médicalisation des Systèmes d'Information (PMSI) hospital database, literature review, and French clinical experts using 2017?Euro tariffs. In order to test the robustness of results, deterministic one-way sensitivity analyses were carried out on the main variables to assess the impact of treatment cost, probability of birth, ovarian hyperstimulation syndrome (OHSS) rates, and dosage.

Results: The average incremental cost per live birth with OHSS and without OHSS was €259.56 and €278.39, respectively, for Gonal-F compared to the pooled biosimilars (i.e. Ovaleap and Bemfola). GONAL-F had an incremental efficacy of 0.06 over the pooled biosimilars. The incremental cost-effectiveness ratio for Gonal-F with OHSS ranged from €3,274.80 to €4,877.76 compared to the pooled biosimilars, owing to the additional live births reported with Gonal-F. Sensitivity analyses also supported results from the base case analyses, with Gonal-F being cost-effective or the dominant strategy in most cases.

Conclusion: Gonal-F seems to be a cost-effective strategy compared to its biosimilars Ovaleap and Bemfola, irrespective of the incidence of OHSS events, but further data are needed to confirm these results.     

What do friends and the media tell us? How different information channels affect women’s risk perceptions of age‐related female infertility

This paper investigates through which channels women receive information about the general risk levels of age‐related female infertility and how the different channels affect women’s perceptions of the risk. We find that the media reaches women of all ages, while only about one woman in four has received information from the health care system. We also find that friends and relatives are an important source of information that affects women’s risk perceptions. However, the information from friends and relatives seems to generally make female recipients more likely to overestimate the risks. We conclude that the information sources have different, sometimes even opposite, impacts on the risk perceptions, possibly making it harder for a woman to be aware of the true general risks of age‐related infertility.     

黄石地区男性不育症患者支原体培养及药敏分析

为了解黄石地区男性不育症患者泌尿生殖系统支原体感染状况及其耐药性,采用支原体分离培养鉴定与药敏试验试剂盒,对男性不育患者精液进行支原体分离培养鉴定及药敏试验。结果为：108例男性不育患者支原体培养阳性42例,阳性率为38．9％,其中解脲支原体（ uu）阳性32例,阳性率为29．6％;混合型支原体7例,阳性率为6．5％;人型支原体（mh）3例,阳性率为2．8％。对照组48例,其中解脲支原体3例,阳性率为6．2％,经统计学处理,x2＝17．25,P ＜0．01,有显著性差异。支原体对药物敏感的为交沙霉素、强力霉素和美满霉素,耐药率较高的是环丙沙星、罗红霉素和氧氟沙星。支原体感染是男性不育的一个重要因素,在诊疗过程中应综合考虑本地区流行情况及药敏试验,合理选择抗生素。     

中医治疗男性不育症1例

探索一种经济安全、疗效可靠的治疗男性不育症方法。男性不育症是生殖医学中最重要的问题之一,文章介绍了巴元明教授采用中医药治疗男性不育症1例,例中患者治疗前精液分析提示:精子活力(A级+B级):1%,诊断为男性不育症(弱精子症)。巴元明教授拟补肾固精,健脾化湿法治之。治疗后复查精液分析提示:精子活力(A级+B级):80%,精子活力明显提高,恢复正常水平。中医药治疗男性不育症有一定疗效。