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1.
The management of acid-related disorders: the burden of disease and the need for effective treatment
《Journal of medical economics》2013,16(1-4):51-67
SummaryA large and increasing number of people suffer from acid-related disorders such as dyspepsia, gastro-oesophageal reflux disease (GORD), and peptic ulcer disease. In 1994 alone, about 2 million patients consulted their family doctor for an acid-related disorder. Treatment of these patients represents a high cost to the NHS in terms of medications, consultations, referrals and treatment of complications. UK government statistics also indicate that there is a huge economic burden associated with acid-related disorders in terms of lost productivity.Effective management of acid-related disorders is required to ensure that the available resources are used efficiently and to the benefit of the NHS, society and the patient.Proton pump inhibitors are the most effective and predictable therapy available for acid-related disorders and many clinical studies have demonstrated their superior efficacy over H2-receptor antagonists in the management of these conditions. These therapeutic advantages translate into economic gains. Several economic studies have shown that it is more cost-effective to treat GORD and peptic ulcer disease with the proton pump inhibitor omeprazole than with H2-receptor antagonists. 相似文献
2.
本文结合当前国有银行战略引资的改革背景,构建银行业混合寡占、国有银行混合持股的古诺竞争均衡模型,研究认为战略引资后的均衡股权结构与国有银行所承担的政策性负担及私有银行数量密切相关;国有银行政策性负担与私有银行的经营绩效正相关,但从整体来看则损害了社会总福利.另外,政策性负担不影响市场可容纳的最大银行数量,但会影响达到这一数量时国有银行的股权结构. 相似文献
3.
《Journal of medical economics》2013,16(4):547-551
AbstractObjectives:Adherence to medication is essential for optimal outcomes, especially for chronic diseases such as multiple sclerosis (MS). Studies in MS indicate that lower adherence is associated with an increased risk of relapse, hospitalization or emergency room (ER) visits, and higher medical costs. A previous investigation assessed the cost per relapse avoided for patients with MS receiving first-line disease modifying therapies (DMTs); however, the model assumed 100% adherence.Methods:Because real-world utilization patterns influence the actual effectiveness of medications, this analysis assessed the impact of real-world adherence from a US commercial payer perspective, using updated costs.Results:As was seen in the original study, in this revised model, fingolimod was associated with the lowest cost per relapse avoided ($90,566), followed by SC IFN β-1b (Extavia: $127,024), SC IFN β-1b (Betaseron: $137,492), SC IFN β-1a ($144,016), glatiramer acetate ($160,314), and IM IFN β-1a ($312,629). The model inputs that had the greatest impact on the results were adherence-adjusted relative relapse rate reduction (RRR) of fingolimod, the wholesale acquisition costs of fingolimod, and the average number of relapses in untreated patients with MS.Limitations:The estimates of DMT adherence are from a single claims database study of a large national pharmacy benefit manager that only measured adherence, not actual relapses, and the model does not incorporate manufacturer discounts and rebates, which are not publicly available.Conclusion:These results suggest that economic analyses of MS therapies should incorporate real-world adherence rates where available, rather than relying exclusively on trial-based efficacy estimates when considering the economic value of treatment alternatives, and that highly efficacious therapies with low adherence may yield real-world efficacy that is substantially lower than that observed in closely monitored clinical trials. 相似文献
4.
《Journal of medical economics》2013,16(12):1020-1028
Abstract
Objective:
This study estimated the economic burden of obesity-related comorbidities (ORCs) in the US, at both the person and population levels. 相似文献5.
Ahong Huang Tony B. Amos Kruti Joshi Li Wang Abigail Nash 《Journal of medical economics》2018,21(10):1026-1035
6.
农村税费改革中存在的问题及对策 总被引:2,自引:0,他引:2
农村税费改革后,农民的负担减轻了,但税费改革中新出现的一些问题严重影响了税费改革的进程和效果。我国农村税费改革存在着城乡之间、城区与非城区农民之间负担不均衡、农村义务教育投入严重不足、村级经费短缺等亟待解决的问题。为此,应采取加大农村政府机构改革的步伐和力度、加大对农村义务教育的投入、加大中央和省级两级财政转移支付力度等措施,进一步完善农村税费改革。 相似文献
7.
This paper empirically assesses if and to what extent cross-country differences in institutions inherited from the past affect current institutional quality in Africa. Specifically, the work evaluates if legal origins and disease endowments explain cross-country differences in the quality of contemporary institutions that are widely considered to be important for financial system development and other economic outcomes, such as those related to creditor rights protection and the credit information infrastructure, as well as the judicial, legal property and insolvency systems. Empirical tests are carried out on a sample of 46 African former European colonies with data on current institutional quality from 2004 to 2013. The findings reveal that the legal origins hypothesis receives strong support in the data: historical factors, rooted in legal origins, have long-lasting effects on current institutional quality in the African context. Mixed evidence is instead found for the endowment view. 相似文献
8.
本文设计了企业社会保险负担率的指标,并根据超越对数生产函数构建了社会保险负担率的测算模型,分析了各地区工业企业的社会保险负担差异。结果表明:第一,我国工业企业社会保险负担从大到小依次是:中部、西部、东部、东北。与当前社会保险"主要向西部地区和东北地区倾斜"倾斜的政策取向存在一定差异。第二,各地区的企业社会保险负担位次,与企业利润水平位次负相关。因此确定企业社会保险缴费基数,应当综合考虑企业劳动报酬和利润水平因素。第三,企业社会保险负担位次与资本投入水平的位次负相关,企业社会保险负担增加将导致资本对劳动的替代,对就业问题产生一定影响。 相似文献
9.
《Futures》2013
This fictional prototype explores two of the future's major societal challenges: the delivery of healthcare to an increasingly ageing society; and the policing of a society, in which digital surveillance may predominate. It contrasts the author's vision of what life could be like in the United Kingdom in a decade's time (just as he contemplates retirement) with the simpler values of the 1980s, when he began his postgraduate career. The lyrics of the poignant 1982 Bruce Springsteen song, “Highway Patrolman” are used to bridge the epochs1. The prototype relocates the two main ‘middle-America’ characters, brothers Joe and Frank Roberts, in London in the year 2025. Much has already changed politically and socially in ‘Western societies’ in the intervening period up to 2012, driven by the inexorable advances of technology. As further scientific advances drive us to an anticipated paradigm change,2 one can only speculate on how society will advance, posing serious ethical dilemmas. Many of the changes will be positive. However, the story explores the potential negative consequences to the ageing population, in what appears to be a successful economy. Although somewhat pessimistic in outlook, a hopeful conclusion is that the ‘ties that bind’ will still predominate. 相似文献
10.