Cost comparison of continued anticoagulation with rivaroxaban versus placebo based on the 1-year EINSTEIN-Extension trial efficacy and safety results

Aims: The EINSTEIN-Extension trial (EINSTEIN-EXT) found that continued treatment with rivaroxaban for an additional 6 or 12 months (vs placebo) after 6–12 months of initial anticoagulation significantly reduced the risk of recurrent venous thromboembolism (VTE) with a small non-significant increased risk of major bleeding (none fatal or in critical site). This study aimed to compare total healthcare cost between rivaroxaban and placebo, based on the EINSTEIN-EXT event rates.

Methods: Total healthcare cost was calculated as the sum of treatment and clinical event costs from a US managed care perspective. Treatment duration and event rates were obtained from the EINSTEIN-EXT study. Adjustment on treatment duration was made by assuming a 10% non-adherence rate. Drug costs were based on wholesale acquisition costs. Cost estimates for clinical events (i.e. recurrent deep vein thrombosis [DVT], recurrent pulmonary embolism, major bleeding, clinically relevant non-major bleeding) were determined from the literature. Results were examined over a ±20% range of each cost component and over 95% confidence intervals (CIs) of event rate differences in deterministic (one-way) and probabilistic sensitivity analyses (PSA).

Results: Total healthcare cost was $1,454 lower for rivaroxaban-treated (vs placebo-treated) patients in the base-case, with a lower clinical event cost fully offsetting drug cost. The cost savings of recurrent DVT alone (–$3,102) was greater than drug cost ($2,723). Total healthcare cost remained lower for rivaroxaban in the majority (73%) of PSA (cost difference [95% CI]?=?–$1,454 [–$2,396, $1,231]).

Limitations: This study was conducted over the 1-year observation period of the EINSTEIN-EXT trial, which limited “real-world” applicability and examination of long-term economic impact. Assumptions on drug and clinical event costs were US-based and, thus, not applicable to other healthcare systems.

Conclusions: Total healthcare costs were estimated to be lower for patients continuing rivaroxaban therapy compared to those receiving placebo in VTE patients who had completed 6–12 months of VTE treatment.     

国际航运中关于贸易术语的几个问题

首先介绍了国际航运中合同性质发生改变的情况和解决问题的办法；接着分析了对贸易术语变形的处理，规定装卸港口应注意的事项，对转运的把握；最后分析了国际航运中货物风险的提前转移。     

干预行为——经济法中的“法律行为”

在我国法学界,"法律行为"有两种不同含义,一是民法上的含义,意指意思效果行为。这也是法律行为的原初含义。另一是法理学上的含义,意指具有法律效果的行为。经济法的法律行为应采何意?从相关的论述看,多是在法理学意义上使用的。笔者之见,法律行为应回归其原初含义,而最能反映经济法特征的法律行为就是"干预行为",即公共经济组织的"公意"表示及执行行为,包括宏观调控和市场规制行为。     

The Recognition and Timing of Deferred Tax Liabilities

Abstract:   This paper examines the characteristics of firms that account for deferred tax liabilities related to government investment grants under an extended adoption timing period. Not only the recognition but also the timing decision is associated with changes in future performance and changes in the debt structure. Recognisers outperform non‐recognisers in the future, while early recognition is related to post recognition performance but only for those firms that currently perform well. Changes in the balance sheet structure are also related to both decisions. Firms with recent increases in the debt level tend to postpone recognition, while currently well‐performing firms that increase their future debt level are less likely to recognise deferred taxes.     

对GB／T 13361—92《技术制图 通用术语》中部分定义的一些意见

就《技术制图与机械制图》中的几个“通用术语”,如投影与视图、轴测投影与轴测图等,从原理上发表自己的一些看法,提出修改意见,指出了该标准中的一些不足之处。     

报废汽车回收体系结构模型研究

报废汽车的回收重用一方面是＂生产者责任延伸制＂在汽车行业贯彻实施的结果,另一方面来源于再制造环节中蕴藏的丰厚利润的诱导.目前我国回收利用报废汽车的方式比较落后,主要是对原材料进行重用.本文构建了一个由汽车制造商牵头纽建,以功能多样化的回收中心作为中心处理单元的报废汽车回收体系结构模型,以期实现更高层次的回收重用.     

谈国际贸易术语的实际运用

本文针对高职经济类专业学生如何学好《进出口贸易实务》课程强调:理解,不死记硬背和生搬硬套;理论联系实 际;与市场接轨,与"灰领"接轨。     

关于少数民族汉语词汇教学中新词新义的思考

当代汉语词汇产生了7000条左右新词语,但在少数民族汉语教学中较少接触。应尽快研制少数民族汉 语教学大纲,并给予相应的教学安排,以便进一步提高少数民族汉语教学质量。     

跨文化词义的比较与翻译

词汇是语言符号和体言中的最小的有意义的语言载体,对跨文化词义的社会性、文化性、民族化、地理环境和喻体相异性、习俗的文化意义等进行比较,有助于跨文化翻译.采用异化法、异化解释法、归化法、归化意译法等方法,将翻译置于跨文化交际中进行,以达到跨文化交际中的文化效应最大近似或对应.     

翻译中词义的理解与表达

翻译中词义的理解与表达起着重要的作用。基于奈达的翻译理论，从英汉互译的角度，通过一些翻译实例，阐明只有正确把握词汇的多义性以及字词在不同文体中的最佳表达，才能使翻译成为一种成功的再创作。