2,3,4-三氟硝基苯合成工艺新进展

2,3,4-三氟硝基苯是合成氟喹诺酮药物的重要中间体.介绍了4条工艺合成路线,按起始原料分,它们是:1)2,6-二氯苯胺法;2)2,6-硝基苯法;3)2,6-溴苯胺法,4是最近提出的新工艺技术,即以1,2,3-三氯苯作原料,通过硝化、氟化制得到产品.产品纯度达99%,收率为60%,这是一条较有发展前景的工业化合成路线,值得引起关注.

New progress on synthesis method for 2,3,4-trifluoronitrobenzene

The 2,3,4-trifluoronitrobenzene is a important pharmaceutical intermediates,for synthesis of fluorquinolo- ne antibacterial agents,such as Tarivid and lamfloxacim etc.At present according to using raw material differences,there are four synthesis methods:1) by 2,6-dichlorobenzenamine through Schieman fluorination reaction,nitration reaction and Swarts fluorine exchange reaction ;2)by 2,3-dichloronitrobenzene as raw material,first steps chlorination,and then through diazotization,fluorination and nitration r...