| 控哮涂膜剂的皮肤致敏性实验研究 |
| |
| 引用本文： | 郭燕蓉,董琳,朱蔚,郑媛,赵庭珠,魏哲,茆建国. 控哮涂膜剂的皮肤致敏性实验研究[J]. 中国药物经济学, 2013, 0(5): 25-26 |
| |
| 作者姓名： | 郭燕蓉 董琳 朱蔚 郑媛 赵庭珠 魏哲 茆建国 |
| |
| 作者单位： | [1]解放军第五医院,宁夏银川750004 [2]宁夏医科大学药学院,宁夏银川750004 |
| |
| 基金项目： | 兰州军区科研课题（项目编号：CLZllGB26） |
| |
| 摘 要： | 目的 考察控哮涂膜剂对动物皮肤是否具有致敏性,为其临床安全性评价提供依据.方法 皮肤致敏性实验通过与2,4-二硝基氯苯对照,采用豚鼠同体左右侧自身比较法研究控哮涂膜剂对皮肤的致敏性.结果 控哮涂膜剂反复致敏后使用,未发生皮肤过敏反应.结论 本品局部用药后,对正常皮肤无致敏性.
|
| 关 键 词： | 控哮涂膜剂 皮肤致敏性 豚鼠 2,4-二硝基氯苯 |
Study on Skin Sensitization of Film agent for Asthma Controlling |
| |
| Guo Yanrong Dong Lin Zhu Wei Zheng Yuan Zhao Tingzhu Wei Zhe Mao Jianguo. Study on Skin Sensitization of Film agent for Asthma Controlling[J]. China Journal of Pharmaceutical Economics, 2013, 0(5): 25-26 |
| |
| Authors: | Guo Yanrong Dong Lin Zhu Wei Zheng Yuan Zhao Tingzhu Wei Zhe Mao Jianguo |
| |
| Affiliation: | Guo Yanrong Dong Lin Zhu Wei Zheng Yuan Zhao Tingzhu Wei Zhe Mao Jianguo |
| |
| Abstract: | Objective To investigate the skin sensitization of film agent for asthma controlling on animals,which can provide the information of pre-clinical safety evaluation for application. Methods The skin sensitization experiment was compared with 2,4-dinitrochlorobenzeneby comparing left and right side of the same body in guinea pigs. Results After sensitization by applications of film agent for asthma controlling, skin allergic reaction did not appears in intact skin. Conclusion Film agent for asthma controlling causes no skin sensitization on normal skin in guinea pigs. |
| |
| Keywords: | Film agent for asthma controlling Skin sensitization Guinea pigs 2,4-dinitrochlorobenzene |
| 本文献已被 维普 等数据库收录！ |
|
