巴拉圭茶对高脂血症小鼠氧化还原状态的影响

探讨不同剂量巴拉圭茶对高脂血症小鼠氧化还原状态的影响。通过高脂日粮建立高脂血脂小鼠模型,随机分为模型组、巴拉圭茶低剂量组、巴拉圭茶高剂量组,对照组饲喂基础日粮,模型组饲喂高脂日粮,巴拉圭茶低剂量组、巴拉圭茶高剂量组饲喂高脂日粮并分别灌胃1 g·kg^-1、2 g·kg^-1巴拉圭茶,连续灌胃4周,处死小鼠,测定小鼠肝脏中活性氧自由基(ROS)水平、超氧化物歧化酶(SOD)活性、过氧化氢酶(CAT)活性、丙二醛(MDA)的含量。与模型组相比,低剂量、高剂量巴拉圭茶可显著降低小鼠肝脏中ROS水平、MDA含量(p<0.05),可显著提高小鼠肝脏中SOD、CAT活性(p<0.05)。巴拉圭茶对高脂血症小鼠氧化应激具有一定的调节作用。

The Effect of Yerba Mate on the Redox State of Hyperlipidemia Mice

To explore the effect of different doses of yerba mate on the redox state of hyperlipidemia mice.A mouse model of hyperlipidemia was established through high-fat diets,and they were randomly divided into model group,low-dose yerba mate group,high-dose yerba mate group,control group fed with basal diet,model group fed with high-fat diet,yerba mate The low-dose group and the high-dose yerba mate group were fed a high-fat diet and gavage 1 g·kg^-1 and 2 g·kg^-1 yerba mate respectively for 4 weeks.The mice were sacrificed and the liver content of the mice was determined.Reactive oxygen free radical(ROS)level,superoxide dismutase(SOD)activity,catalase(CAT)activity,malondialdehyde(MDA)content.Compared with the model group,low-dose and high-dose yerba mate can significantly reduce the level of ROS and MDA in the liver of mice(p<0.05),and can significantly increase the activity of SOD and CAT in the liver of mice(p<0.05).Yerba mate has a certain effect on regulating oxidative stress in hyperlipidemia mice.