| 嘧菌酯的新合成方法 |
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| 引用本文： | 祁同生,赵 娜,马彩霞,次素英,张丽荣,赵立峰. 嘧菌酯的新合成方法[J]. 河北工业科技, 2014, 31(6): 498-501 |
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| 作者姓名： | 祁同生 赵 娜 马彩霞 次素英 张丽荣 赵立峰 |
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| 作者单位： | 河北威远生化农药有限公司,河北石家庄,050031 |
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| 基金项目： | 石家庄市科技局科技攻关项目 |
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| 摘 要： | 报道了一种广谱高效杀菌剂嘧菌酯的新合成方法,首先以2-氯苯甲腈与4,6-二羟基嘧啶为原料催化合成4-羟基-6-(2-氰基苯氧基)嘧啶,氯化得到4-氯-6-(2-氰基苯氧基)嘧啶。将4-氯-6-(2-氰基苯氧基)嘧啶与(E)-2-(2-羟基苯基)-3-甲氧基丙烯酸甲酯耦合,生成(E)-2-(2-(6-(2-氰基苯氧基)嘧啶-4-基氧)苯基)-3-甲氧基丙烯酸甲酯(嘧菌酯)。3步总收率为79.8%(以2-氯苯甲腈计),原药质量分数为97%。
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| 关 键 词： | 杀菌剂 嘧菌酯 合成 |
| 收稿时间： | 2014-06-25 |
| 修稿时间： | 2014-08-20 |
New synthetic method of azoxystrobin |
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| QI Tongsheng,ZHAO N,MA Caixi,CI Suying,ZHANG Lirong and ZHAO Lifeng. New synthetic method of azoxystrobin[J]. Hebei Journal of Industrial Science & Technology, 2014, 31(6): 498-501 |
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| Authors: | QI Tongsheng ZHAO N MA Caixi CI Suying ZHANG Lirong ZHAO Lifeng |
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| Affiliation: | Hebei Veyong Bio-chemical Company Limited;Hebei Veyong Bio-chemical Company Limited;Hebei Veyong Bio-chemical Company Limited;Hebei Veyong Bio-chemical Company Limited;Hebei Veyong Bio-chemical Company Limited;Hebei Veyong Bio-chemical Company Limited |
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| Abstract: | A new synthetic method of the broad-spectrum fungicide azoxystrobin is reported.First 4-hydroxy-6-(2-cyanophenoxy)pyrimidine is prepared by the reaction of 2-chlorbenzonitrile with 4,6-dihydroxypyrimidine in the presence of catalysts,then it is chlorinated to 4-chloro-6-(2-cyanophenoxy)pyrimidine.Finally the condensation of 4-chloro-6-(2-cyano phenyl)pyrimidine with(E)-2-(2-hydroxyphenoxy)-3-methoxy acrylic ester produces azoxystrobin with total yield of 79.8%(counted by 2-chlorbenzonitrile)and active compound mass fraction of 97%. |
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| Keywords: | fungicide azoxystrobin synthesis |
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