Multiple aspect testing for case-control designs |
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Authors: | Luigi Salmaso Aldo Solari |
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Institution: | (1) Department of Statistical Sciences, University of Padova, via Cesare Battisti 241, 35121 Padova, Italy |
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Abstract: | When testing for the equality of two distributions in a case-control design with treatment effects presumed to act possibly
on more than one aspect, different tests may be properly considered for testing for different features of a null hypothesis,
leading to the multiple aspect testing issue. Two different aspects are therefore of interest: the location-aspect, based
on the comparison of location indexes, and the distributional-aspect, based on the comparison of the empirical distribution
functions. A simulation study shows that the combined testing procedure exhibits a good robust overall performance, and an
application in biomedical research is also presented. |
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Keywords: | Case-control design Multi-aspect Multiple hypotheses testing Nonparametric combination methodology Permutation tests |
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