| 癫痫发作诱导神经元死亡的机制 |
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| 引用本文： | 陈玉华.癫痫发作诱导神经元死亡的机制[J].黄石理工学院学报,2011,27(3):58-62. |
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| 作者姓名： | 陈玉华 |
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| 作者单位： | 黄石理工学院医学院,湖北黄石,435003 |
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| 摘 要： | 对发作诱导神经元死亡的分子途径的阐明可能为抵抗持续反复的癫痫发作以保护大脑神经元提供新的策略。除了谷氨酸盐介导的兴奋性中毒和坏死外，发作也激活程序性细胞死亡（凋亡）途径。癫痫持续状态导致未成熟大脑的海马神经元的损伤，但是损伤的模式和机制还不清楚，实验结果表明神经元的不成熟是产生凋亡模式的一个因素。在戊四氮（PTZ）致痫大鼠模型中NOS早期可能参与癫痫发生，后期可能通过诱导NF—κB产生而参与了神经细胞的凋亡。
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| 关 键 词： | 癫痫 发作 癫痫持续状态 损伤 凋亡 坏死 |
Mechanism of Neuronal Death Caused by Epilepsy Seizure |
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| CHEN Yuhua.Mechanism of Neuronal Death Caused by Epilepsy Seizure[J].Journal of Huangshi Institute of Technology,2011,27(3):58-62. |
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| Authors: | CHEN Yuhua |
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| Institution: | CHEN Yuhua(School of Medicine,Huangshi Institute of Technology,Huangshi Hubei 435003) |
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| Abstract: | Demonstration of the pathway to lead to the neuronal death may provide new strategy for the resistance of the persisting and recurring epilepsy seizure and for the protection of brain neuronal.Glutamate-mediated excitotoxicity and necrosis is a primary contributing mechanism but seizures also activate programmed(apoptotic) cell death pathways.Status epilepticus in the immature brain results in neuronal injury in the hippocampal formation,but the mode and mechanism of death are poorly understood.Experiments ... |
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| Keywords: | epilepsy eizure status epilepticus injury apoptosis necrosis |
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